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Kidney & Blood Pressure Research, Pp 1-31 (2026)
Scopus
ISSN 1420-4096 · Karger Publishers · 1,310 articles in the index
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Journal Article
ATHENA Study – The Role of Circulating Plasma MicroRNAs in Pediatric Patients with Untreated Primary Hypertension: Baseline Expression and Exercise-Induced Changes
BACKGROUND: The role of microRNA in primary hypertension remains unclear. This study examined the expression of microRNA-16, -21, -27a, -27b, -133a, and -145 in untreated hypertensive children, their response to aerobic exercise, and correlations with blood pressure and related parameters. METHODS…
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Journal Article
Higher expression of miR-155 and miR-103 in patients with Gitelman’s syndrome: potential implications for Angiotensin II-induced cardiovascular remodeling in hypertension.
Introduction: miR-155 and miR-103 are multifunctional miRNAs known to be involved in Angiotensin II (Ang II) signaling linked with hypertension and cardiovascular remodeling, although their role is controversial and not completely clarified. Gitelman syndrome (GS), rare genetic tubulopathy…
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Journal Article
From Preservation to Regeneration: Stem Cell-Derived Therapies in Machine-Perfused Kidney Transplants – A systematic Review and Meta-analysis
The integration of regenerative medicine into dynamic organ preservation may mitigate ischemia-reperfusion injury in kidney transplantation. This systematic review and meta-analysis evaluated the therapeutic potential of stem cell-based interventions during machine perfusion. Following PRISMA…
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Journal Article
Drugs to Slow Progression of Chronic Kidney Disease: It’s a Whole New World!
Chronic kidney disease (CKD) affects approximately 14% of adults in the United States and about 10% worldwide and remains a major public health concern. Diabetes and hypertension are the leading causes of CKD and contribute to progressive nephron loss through disturbances in glomerular hemodynamics…
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Journal Article
Inflammatory biomarkers in the assessment of kidney function decline in Long Covid syndrome
Introduction: Long Covid (LC) is an inflammatory condition, affecting multiple organs, including kidneys. This study aims to identify a signature of inflammatory biomarkers that can predict, describe, and monitor kidney function decline in LC patients. Methods: A single-center observational study…
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Journal Article
Nutritional Status as Predictor for Mortality in Older Adults With Acute Kidney Injury
Older adults (OA) exhibit the highest incidence of acute kidney injury (AKI), with outcomes influenced by comorbidities, frailty, and malnutrition. Nutritional status, a potentially modifiable factor, has not been extensively evaluated as a mortality predictor in hospitalized OA with AKI. Our…
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Journal Article
Impact of Renal Replacement Therapy on Severe Lactic Acidosis in ICU Patients: A MIMIC-IV retrospective replication analysis
Introduction. Severe lactic acidosis (SLA), defined as lactate ≥5 mmol/L, is a critical condition in intensive care unit (ICU) patients and is associated with high mortality. Despite the broad use of renal replacement therapy (RRT) to manage metabolic derangements, its impact on outcomes in SLA…
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Journal Article
Verapamil reduces collagen synthesis to alleviate ureteral scar formation by inhibiting KDM1A-mediated epigenetic silencing of SESN2
Background: Ureteral scar formation is a fibrotic process linked with collagen synthesis. Although autophagy prevents collagen synthesis, its role in ureteral scarring remains unclear. Therefore, this study investigated the modulation of SESN2-mediated autophagy by verapamil during ureteral scar…
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Journal Article
Infective endocarditis-associated glomerulonephritis caused by Streptococcus cristatus: A Case Report
Introduction: Infective endocarditis (IE) can trigger systemic embolic and immune-mediated complications, including infection-related glomerulonephritis (IRGN). When the infectious focus is IE, the condition is termed IE-associated glomerulonephritis (IEAGN). A major diagnostic pitfall is that…
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Journal Article
Simplified Subjective Global Assessment at Hemodialysis Initiation and Its Association with 2-Year Mortality and Hospitalization
Introduction: Nutritional risk assessment, which is necessary for initiating appropriate nutritional therapy to improve prognosis, should be as simple as possible to perform, particularly when direct patient contact is limited. We examined whether simplified Subjective Global Assessment (SGA), a…
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Journal Article
Cystine-binding medication is poorly accessible for the treatment of cystinuria
Introduction Cystinuria is a rare inherited disorder characterized by recurrent cystine stone formation. When lifestyle modification and urine alkalinization fail, cystine-binding medication such as tiopronin and D-penicillamine are indicated. Despite proven benefit, their accessibility across…
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Journal Article
Long-Term Betaine Supplementation Increases Creatinine Clearance and Upregulates MAS and AT2 Receptor Expression in Spontaneously Hypertensive Rat Kidneys
Hypertension contributes to renal dysfunction, partly through dysregulation of the renin-angiotensin system (RAS). Betaine, an osmolyte that helps maintain medullary osmotic gradients, has demonstrated renoprotective effects in models of nephrotoxicity. Previously, we showed that acute betaine…
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Journal Article
Epidemiology and multimorbidity in hemodialysis patients at a tertiary care center in northern Mexico: implications for hospital-based adverse outcomes
Introduction: Patients with chronic kidney disease (CKD) in maintenance hemodialysis are vulnerable to adverse hospital-based outcomes. The present study aimed to describe the association between clinical variables and hospital admission and mortality in patients ascribed to an outpatient…
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Journal Article
SIRT6 attenuates angiotensin II-induced podocyte cholesterol accumulation and injury via negative modulation of SREBP2
Introduction: Angiotensin (Ang) II can cause podocyte injury and leads to chronic kidney disease (CKD), but the specific mechanism is not clear. In our previous study, we found that Ang II reduced the expression of cholesterol efflux associated molecule by regulating Sirtuin 6 (SIRT6), thereby…
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Journal Article
Ascitic Fluid Drainage Before Dialysis Catheter Removal for Peritoneal Dialysis-Related Peritonitis
Introduction Persistent ascites requiring drainage following catheter removal because of peritoneal dialysis (PD)-related peritonitis is a common complication associated with prolonged hospitalization and increased mortality. To mitigate this risk, a free drainage protocol was introduced before…
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Journal Article
Association of Body Mass Index Trajectories with Kidney Stone Disease: An Analysis Based on the NHANES Database
Background: Body mass index (BMI), a key indicator of obesity, has been shown by numerous studies to be associated with the risk of kidney stone disease (KSD). However, existing research has predominantly focused on BMI measurements at single time points, thereby failing to adequately capture the…
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Journal Article
The inflammatory milieu exacerbates Anemia of CKD: From the gut–kidney axis to bone marrow hematopoiesis inhibition
Traditionally, erythropoietin (EPO) deficiency has been known as a central component of the pathophysiology of anemia in chronic kidney disease (CKD). Although renal injury is the primary factor causing EPO deficiency, notably, the efficacy of hypoxia-inducible factor prolyl hydroxylase inhibitors…
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Journal Article
The Effect of Renal Ischemia/Reperfusion on the Renal Expression of Epithelial Sodium Channels in Rat: Possible Role of Neural Precursor Cell-Expressed Developmentally Down-Regulated Protein (Nedd4-2)
Introduction: The epithelial sodium channel (ENaC) expressed in renal collecting duct epithelia plays a key role in regulating sodium balance. ENaC is regulated by the ubiquitin ligase Nedd4-2, which binds to ⍺ENaC and causes its retrieval, under low energy conditions due to the activation of AMP…
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Journal Article
A Phenome-Wide Association and Mendelian Randomization Study of Genetically Predicted Membranous Nephropathy with Multiple Diseases
Introduction: Membranous nephropathy constitutes a significant proportion of cases leading to end-stage renal disease. In such instances, the accurate distinction between primary and secondary forms is crucial for proper treatment. Consequently, we systematically examined the link between…
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Journal Article
Morphometric and Functional Evaluation of Nonrenal Vasculature in Female and Male PKD/Mhm (Cy/+) Rats
Introduction: Polycystic kidney disease (PKD) is a genetic disorder characterized by renal enlargement due to cyst formation. Besides cystic complications, patients with autosomal dominant PKD (ADPKD) can develop vascular abnormalities. We investigated the impact of ADPKD on aortic morphometry and…
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