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RNA Biology
Scopus
ISSN 1547-6286 · Taylor & Francis Group · 429 artikel di indeks
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Artikel Jurnal
Chromatin remodelling: a driving force in reverse mechanotransduction
Chromatin serves as the dynamic carrier of genetic and epigenetic information in eukaryotic cells, playing a pivotal role in maintaining nuclear shape, mechanical stability, and cellular function. Aberrant nuclear morphology, often observed in mechanically stressed environments or diseases such as…
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Artikel Jurnal
Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition of m6A
HNRNPA2B1 contains two RRM domains and has been investigated for its possible role as an m6A reader protein. The targetome of HNRNPA2B1 was shown to overlap with the m6A methylation motif, but further investigations of its binding affinity for m6A-containing RNAs have been less clear on the…
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Artikel Jurnal
Essential role of hsa-miR-203a-3p in type I interferons immune homeostasis during influenza and NDV infection
MicroRNAs (miRNAs) are small, non-coding RNA molecules that act as essential post-transcriptional regulators in various biological processes. Many studies suggest that miRNAs may modulate the host’s immune response or even viral replication during infection. We have identified hsa-miR-203a-3p as a…
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Artikel Jurnal
lncRNAs: key player in Aβ deposition
Alzheimer’s disease (AD) is a typical neurodegenerative disorder, characterized by the deposition of β-amyloid (Aβ) plaques. β- and γ-secretases generate Aβ by cleaving amyloid precursor protein. The imbalance between its production and clearance leads to Aβ accumulation, causing neuronal damage…
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Artikel Jurnal
Optimizing protocols for microRNA profiling of infant and toddler stool
Despite growing interest in profiling microRNAs (miRNAs) in infant and toddler stool, no studies have compared protocols for preserving and extracting miRNAs from this specimen type.Three commercially available kits and four preservation methods were compared for their ability to yield high quality…
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Artikel Jurnal
Molecular insights into dynamic RNA quaternary assemblies
Quaternary assembly of proteins frequently plays essential roles in biological processes. In contrast, natural RNA oligomers have rarely been reported. The majority of observed RNA quaternary structures are symmetric homodimers, while recent studies have also revealed structures of heterodimers and…
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Artikel Jurnal
5PSeq Explorer: interactive analysis of co-translational mRNA decay and ribosome dynamics
Co-translational mRNA decay occurs when 5’to3’ exonucleases follow the last translating ribosome, generating in vivo ribosome protected fragments. Degradome sequencing (5PSeq)therefore offers unique insights into ribosome dynamics. Despite its potential, resources for systematic analysis of 5′P…
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Artikel Jurnal
Advanced deep learning strategies in nanopore RNA sequencing
The epitranscriptome comprises chemical modifications found on RNA molecules that play essential roles in co- and post-transcriptional gene regulation. Dysregulation of these modifications has been implicated in various diseases, fuelling interest in evaluating them as emerging biomarkers and…
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Artikel Jurnal
A transformer-based method for the cap analysis of gene expression and gene expression tag associated capping region prediction in RNA
5’ RNA capping is one of the major post-transcriptional modifications for the mobility and stability of RNA molecules. Measuring 5’ caps of RNAs can help quantify expression levels of mRNAs and lncRNAs. One of the most successful RNAseq methods that has used capping as a tool to quantify expression…
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Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance
Tumorigenesis is commonly driven by genetic mutations and disruptions in cellular signalling pathways. Here we show that the oncogenic overexpression of the RNase L inhibitor ABCE1, a component of interferon signalling, leads to distinct and extensive deviations in cancer transcriptomes. RNase L is…
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Artikel Jurnal
Cas10 residues lining the target RNA binding channel regulate interference by distinguishing cognate target RNA from mismatched targets
Type III CRISPR systems are defined by the presence of the Cas10 protein and are among the most abundant CRISPR systems in nature. Cas10 forms a complex with crRNA and several Cas proteins that surveils prokaryotic cells for foreign RNA molecules and when they are detected it activates a cascade of…
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Artikel Jurnal
LINC00852 inhibits colorectal cancer progression by regulating cell apoptosis, epithelial‒mesenchymal transition, invasion, and cuproptosis through miR-1276/LACTB
Exploring the role of key genes in colorectal cancer (CRC) progression to identify effective targets is highly practical. Previous studies have shown that miR-1276/ACTB plays an important regulatory role in CRC. In addition to miRNA, lncRNA also play a crucial role in tumour progression. However…
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Artikel Jurnal
Sequence and ionic requirements of pUG fold quadruplexes
Poly(UG) repeats or pUG RNAs can fold into a left-handed parallel quadruplex, the pUG fold. The pUG fold directs the epigenetic amplification of RNAi in Caenorhabditis elegans, and pUG sequences are abundant in eukaryotic transcriptomes. Here, we report the sequence and ionic requirements for pUG…
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Artikel Jurnal
Decoding RNA–protein interactions using high-throughput methods
RNA-binding proteins (RBPs) constitute a diverse class of proteins essential for every stage of the gene expression process. Many RBPs are also linked to human diseases and pathologies. Understanding the molecular grammar of RNA–protein interactions is critical for deciphering the regulatory RNA…
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Production of MarathonRT and its comparison with commercial reverse transcriptases for tRNA sequencing library preparation
Over the past decade, groundbreaking discoveries have cemented transfer RNAs (tRNAs) as versatile regulators of translation and cellular function. As tRNA research gains momentum, several high-throughput sequencing methods have emerged for quantitative analysis of tRNA isoacceptors in cells…
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Artikel Jurnal
MicroRNA circuits and regulatory networks: emerging therapeutic paradigm
MicroRNAs (miRNAs) are small non-coding RNAs whose function is to regulate gene expression post-transcriptionally. Transcription factors (TFs) are the DNA-binding proteins responsible for activation or repression of a gene. Together, miRNAs and TFs form regulatory networks that modulate cellular…
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Artikel Jurnal
The lncRNA ZNF295-AS1 alleviates lung squamous cell carcinoma progression by reducing miR-96-5p and inhibiting cancer cell invasiveness
Lung squamous cell carcinoma (LUSC) is highly invasive, and patients with advanced disease generally have a poor prognosis. ZNF295-AS1 is abnormally expressed in lung cancer. This study aims to investigate the prognostic value of ZNF295-AS1 in LUSC and its potential regulatory mechanisms. This…
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Artikel Jurnal
miR-34 regulates cuticle pigmentation by targeting Bm-iAANAT and Bmserpin3 in Bombyx mori
Pigmentation is an orchestrated process involved in cuticle melanization and sclerotization in insects, and plays a critical role in maintaining the structural integrity and functional completeness of the insect cuticle. Although the cascade reactions underlying pigmentation have been extensively…
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Artikel Jurnal
Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids
Replacing maternal colostrum and milk with those from other species is common practice in neonatal ruminant management, but the effects on small non-coding RNA (sncRNA) transmission remain poorly understood. This study investigated whether colostrum and milk replacement alters circulating sncRNA…