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PLoS Medicine
Scopus
ISSN 1549-1676 · Public Library of Science (PLoS) · 12,226 articles in the index
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Journal Article
Correction: Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics.
[This corrects the article DOI: 10.1371/journal.pmed.1003636.].
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Journal Article
Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety.
Glucagon-like peptide-1 (GLP-1)-based medications, such as semaglutide and tirzepatide, have transformed obesity care. However, rising use brings concerns about side effects, long-term outcomes, and unregulated products. Ensuring safe access requires oversight, monitoring, and coordinated clinical…
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Journal Article
Multiview deep-learning-enabled histopathology for prognostic and therapeutic stratification in stage II colorectal cancer: A retrospective multicenter study.
BackgroundApproximately 20% of patients with stage II colorectal cancer (CRC) experience tumor relapse despite standard surgical treatment. Histopathological analysis holds promise for postsurgical risk stratification and guiding adjuvant chemotherapy (ACT) decisions. The aim of this study was to…
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Journal Article
Oral preexposure prophylaxis use and the risk of bacterial sexually transmitted infections and HIV among African women: A prospective observational cohort study.
BackgroundOral preexposure prophylaxis (PrEP) effectively reduces HIV incidence when used with sufficient adherence, but does not protect against bacterial sexually transmitted infections (STIs). Several studies have documented high rates of bacterial STIs among individuals initiating and using…
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Journal Article
Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis: A modelling study.
BackgroundTuberculosis (TB) remains a leading cause of infectious disease death. New TB vaccines are currently in late-stage trials and may be available before the end of the decade. Modelling predicts new TB vaccines may reduce global burden but rely on assumptions about vaccine efficacy by TB…
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Journal Article
Cost-effectiveness and benefit-cost analyses of promoting handwashing with soap: A systematic review.
BackgroundPromoting handwashing with soap reduces risk of diarrhoea by 30% and respiratory infections by 17%. Handwashing promotion in nonhealthcare settings is widely considered cost-effective, but there is no systematic review on this topic. To inform resource allocation decisions, we reviewed…
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Journal Article
Cost-effectiveness of esketamine versus alternative treatment strategies for treatment-resistant depression in Hong Kong: A multi-armed modeling study.
BackgroundTreatment-resistant depression (TRD), defined as failure to respond to at least two adequately administered antidepressant (AD) regimens, imposes major clinical and economic burdens. Esketamine nasal spray offers rapid antidepressant clinical effects, yet previous evaluations compared it…
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Journal Article
The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR).
Dementia is a leading health policy challenge, with cases expected to triple by 2050, particularly in low- and middle-income countries. Epidemiological evidence demonstrates falling age-specific incidence rates in high-income countries, suggesting risk can be lowered at the population level.The…
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Journal Article
Subsequent primary cancer incidence among cancer survivors in the United States, 1975-2019: An age-period-cohort analysis.
BackgroundThe growing population of cancer survivors faces elevated risks of subsequent primary cancers (SPCs), yet temporal patterns in SPC incidence remain poorly understood. This study aims to characterize age-, period-, and cohort-specific patterns in SPC incidence among US cancer survivors…
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Journal Article
Optimizing dengue vaccination strategies.
Dengue is a rapidly expanding global health threat driven by urbanization, climate change, and complex transmission dynamics. Modeling and tailored vaccination programs will be critical to developing effective, context-specific strategies to reducing disease burden.
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Journal Article
Correction: Reassessing BMI-based access to joint replacement surgery.
[This corrects the article DOI: 10.1371/journal.pmed.1005003.].
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Journal Article
Identifying novel prodromal symptoms of eclampsia: A two-country, case-control study.
BackgroundMagnesium sulphate halves the risk of eclampsia. There is no consensus on who to give magnesium sulphate prophylaxis because clinical tools are poor at identifying those at risk. Known prodromal symptoms such as headache, visual disturbance, or epigastric pain have modest associations…
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Journal Article
Obesity and cancer: Methodological frontiers for mechanistic discoveries.
It has long been a biological mystery why obesity increases cancer risk. Rapid advances in statistical and analytical methods are now opening the door to mechanistic discoveries that may finally resolve this question.
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Journal Article
Multimorbidity, health service use, and health insurance by socioeconomic groups in 31 countries: A multi-cohort study.
BackgroundThe prevalence of physical, psychological, and cognitive multimorbidity is characterised by marked socioeconomic status (SES) inequalities. However, the relationships between multimorbidity patterns-particularly those involving cognitive conditions-and healthcare utilisation, as well as…
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Journal Article
Pregnancy outcomes in women at high risk of preterm birth receiving a vaginal cervical cerclage with, or without, progesterone: A retrospective, secondary analysis of the C-STICH randomised controlled trial data.
BackgroundVaginal cervical cerclage and progesterone are established treatments for prevention of pregnancy loss and prematurity. There is limited data to assess the effect of these treatments in combination. The objective of this study was to investigate the association between progesterone and no…
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