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Bioinorganic Chemistry and Applications
Scopus
ISSN 1565-3633 · Wiley · 750 artikel di indeks
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Artikel Jurnal
Tolcapone Interferes With Key Pathological Features in Alzheimer’s Disease
Tolcapone, a clinically approved drug for the treatment of Parkinson’s disease as an adjunct therapy, has recently emerged as a potential modulator of amyloid-β aggregation and toxicity, which are hallmark features of Alzheimer’s disease and are also involved in ocular neurodegenerative disorders…
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Artikel Jurnal
A Glimpse in the Metal Ion Selectivity Rules: Zn(II), Cd(II) and Co(II) Interplay With Different Protein Coordination Spheres in Determining Variable Thermal Stability and Folding Scenarios
In this study, the binding properties to Zn(II), Co(II) and Cd(II) of the protein Ros87-C27D, Ros87 mutant with a CysAspHis2 coordination sphere, are investigated by means of UV–vis, CD and NMR spectroscopies. Dissociation constants, structural effects and the resulting mechanisms of folding are…
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Artikel Jurnal
Synthesis, Topological, and Biological Studies of a Novel One-Dimensional Hg(II) Coordination Polymer With Antibacterial and Anticancer Potentials
A novel one-dimensional mercury coordination polymer (CP), identified as [(μ2-Cl)(Ina)Hg(μ3-Cl)Hg(μ2-Cl)2(Ina)]n (1) (where Ina represents isonicotinic acid or 4-pyridinecarboxylic acid), was synthesized via the interaction of isonicotinic acid with mercury(II) salt. This synthesis was achieved…
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Artikel Jurnal
Shape-Directed Hydrothermal Design of Zinc Oxide Nanoparticles for Antimicrobial and Anticancer Applications
The emergence of antibiotic-resistant bacteria represents one of the most pressing challenges in global healthcare. In this study, metal oxide–based nanomaterials are gaining prominence due to their antimicrobial and anticancer potential. In the present study, six new zinc oxide nanoparticles…
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Artikel Jurnal
Substitution Kinetics, DNA/BSA Interactions, Cytotoxicity Evaluation and Computational Analysis of [bis-(azaaryl)amine)Pt(II)/Pd(II)Cl] Complexes, Azaaryl = Quinoline or Phenanthridine
The search for metal-based anticancer agents with improved efficacy and reduced side effects is ongoing. The activities of these anticancer drugs depend on their aqueous stability, substitutional reactivity at target sites (cytotoxicity) and nontarget sites (toxicity), as well as their…
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Artikel Jurnal
Ag-Decorated Hydrogen Molybdenum Bronze Nanotubes as Dual-Action Agents Against Bacillus subtilis: Experimental and Theoretical Insights Into Membrane Damage and Protein Interference
Bacterial biofilms are a persistent challenge in industrial settings such as water treatment and food processing, contributing to antimicrobial resistance, operational inefficiencies, and environmental burden. Here, we report on the synthesis and multiscale evaluation of hydrogen molybdenum bronze…
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Artikel Jurnal
C2-Symmetric Pseudopeptidic Schiff Bases Drive Discrete M2L2 Complexes: Coordination, Stability, and Photophysical Response
We report the design and synthesis of two new C2-symmetric, multifunctional pseudopeptidic ligands derived from L-valine and L-phenylalanine that integrate dual Schiff-base units (one per amino-acid fragment) and an aromatic central spacer. These ligands were rationally engineered to favor the…
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Artikel Jurnal
The Antimicrobial and Cytotoxic Activity of Green-Synthesized Silver Nanoparticle Extract of Marine Bacteria and Their 16S rRNA Identification and Characterization
Marine bacteria represent a substantial underexplored reservoir of bioactive metabolites with significant biomedical potential. Through 16S rRNA gene sequencing, this study identified four bacterial isolates associated with the marine sponge Callyspongia siphonella. They were Gammaproteobacterium…
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Artikel Jurnal
Lactobionic Acid as a Biocompatibility Switch: Physicochemical and Biological Characterization of Copper(II)–Primaquine Complexes
Metal dyshomeostasis and oxidative stress are implicated in the progression of cancer, and neurodegenerative and peripheral aggregation-related disorders. In this study, we investigated primaquine (PQ), a clinically used antimalarial drug, and PQ–lactobionic acid conjugate (LAPQ), a newly…
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Artikel Jurnal
Synthesis, Characterization, and Anticancer Activity of Vanadium (III) Complexes With Pyridyl–Triazole Ligands
Three new V (III) complexes with triazole ligands were obtained and fully characterized using regular analytical techniques, including the unequivocal determination of the structure of complex VL3D by single-crystal x-ray diffraction analysis. The formation of VL3D involves an oxidation process…
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Artikel Jurnal
Synthesis, Characterization, Electrochemical Properties, and DNA-Binding Studies of Novel Schiff Base Metal Complexes: Catalysts in Transfer Hydrogenation of D-Glucose-Like Aldose Reductase Mimetics
In this study, the Schiff base (E)-4-chloro-2-(((4-(phenylamino)phenyl)imino)methyl)phenol (Sadpa), obtained from the condensation reaction of 5-chloro-2-hydroxybenzaldehyde and N1-phenylbenzene-1,4-diamine and reported for the first time in the literature, together with its Co(II) and Pd(II)…
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Artikel Jurnal
Heteroleptic Metal Complexes of 4-(2-Pyridylazo)resorcinol and 1,10-Phenanthroline: Synthesis, Comprehensive Characterization, Electrochemical and Antioxidant Properties, and Computational Investigations
New heteroligand metal complexes, [M(phen) (PAR) (OAc)]·H2O (M = Mn(II) (1), Cu(II) (3)) and [Co(phen) (PAR) (H2O)]OAc·H2O (2), incorporating 4-(2-pyridylazo)resorcinol (PAR) as the primary ligand and 1,10-phenanthroline (phen) as the secondary ligand, were synthesized and comprehensively…
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Artikel Jurnal
ADMET Profiling of the Metallodrugs: A Comparative Review of Platinum, Palladium, Gold, Ruthenium, Copper, and Zinc Anticancer Complexes
The successful clinical use of metal-based anticancer agents depends heavily on a detailed understanding of their absorption, distribution, metabolism, excretion, and toxicology (ADMET) profiles. This review evaluates the ADMET properties of anticancer complexes involving platinum, palladium, gold…
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Artikel Jurnal
All Platinum(II) Ions Are Equal, but Some React Differently: Insights Into the Biomolecular Reactivity of Platinum(II)-Based Anticancer Agents
Platinum-based anticancer agents are widely used in cancer therapy due to their efficacy in killing cancer cells through interactions with the DNA. However, their clinical application is limited by severe side effects and the development of drug resistance, which have been related to their lack of…
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Artikel Jurnal
Eco-Friendly Synthesis of Cynara scolymus Extract–Mediated Nickel Oxide Nanoparticles for Antibacterial and Catalytic Wastewater Applications: Experimental and Molecular Docking Evidence
Green synthesis of nanomaterials offers a sustainable approach for water remediation. In this study, nickel oxide nanoparticles (NiONPs) were synthesized using the Cynara scolymus L. head (CSH) extract via an eco-friendly, cost-effective route and evaluated for antibacterial and catalytic…
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Artikel Jurnal
Synthesis, Characterisation and Structural Analysis of Rhenium and Technetium Nitride Complexes With Tridentate Thiosemicarbazone-Phenols and Phosphine Ligands: Potential Applications in Technetium-99m Radiotracer Development
The reactivity of two tridentate salicylthiosemicarbazones (H2L1 = 3-methoxysalicylaldehyde thiosemicarbazone; H2L2 = 3-methoxysalicylaldehyde N,N-dimethyl-thiosemicarbazone), with the [MV ≡ N]2+ core (M = Re, 99mTc), is here described, leading to the formation of heteroleptic complexes of the…
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Artikel Jurnal
Photoactivation in Chemotherapeutic Compounds for Cancer Treatment: Opportunities Beyond Photodynamic Therapy
Photoactivation is the stimulation or regulation of a chemical or a chemical process by utilizing light of specific wavelength that corresponds to an absorbance optimum of the agent being used and can penetrate into tissues. In cancer therapy, photoactivatable drugs utilize this phenomenon by…
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Artikel Jurnal
Green Synthesis of Iron (III) Oxide Nanoparticles Using Croton macrostachyus Stem Bark Extract and Their Antibacterial and Antifungal Activities
In this study, maghemite nanoparticles (γ-Fe2O3 NPs) were successfully synthesized using Croton macrostachyus stem bark extract (CMSBE) and hexahydrate ferric chloride (FeCl3.6H2O). The biomolecules found in the plant extract were screened through visual observations, and these molecules were used…
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Artikel Jurnal
Guanidine Ligands as Versatile Scaffolds for the Development of Antitumor Ruthenium–Based Metallodrugs
The straightforward catalytic synthesis of guanidine ligands has been evaluated as a strategy for rapidly developing ruthenium metallodrugs as antitumor agents. A series of structurally guanidine ligands, obtained via guanylation reactions, were used as scaffolds for generating RAPTA-C derivatives…