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Artikel Jurnal
N-cadherin induces partial differentiation of cholinergic presynaptic terminals in heterologous cultures of brainstem neurons and CHO cells
N-cadherin is a calcium-sensitive cell adhesion molecule commonly expressed at synaptic junctions and contributes to formation and maturation of synaptic contacts. This study used heterologous cell cultures of brainstem cholinergic neurons and transfected Chinese Hamster Ovary (CHO) cells to…
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Artikel Jurnal
Nicotine exposure during adolescence alters the rules for prefrontal cortical synaptic plasticity during adulthood
The majority of adolescents report to have smoked a cigarette at least once. Adolescence is a critical period of brain development during which maturation of areas involved in cognitive functioning, such as the medial prefrontal cortex (mPFC), is still ongoing. Tobacco smoking during this age may…
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Artikel Jurnal
Homer 1 gene products orchestrate Ca2+-permeable AMPA receptor distribution and LTP expression
We studied the role of Homer1 gene products on the presence of synaptic Ca2+-permeable AMPA receptors (AMPARs) and LTP generation in hippocampal CA1 pyramidal neurons, using mice that either lacked all Homer1 isoforms (Homer1 KO) or overexpressed the immediate early gene product Homer1a (H1aTG). We…
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Artikel Jurnal
SynProt: A Comprehensive Database for Proteins of the Detergent-Resistant Synaptic Junctions Fraction
Chemical synapses are highly specialized cell-cell contacts for communication between neurons in the CNS characterized by complex and dynamic protein networks at both synaptic membranes. The cytomatrix at the active zone (CAZ) organizes the apparatus for the regulated release of transmitters from…
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Artikel Jurnal
Synaptic signaling and aberrant RNA splicing in autism spectrum disorders
Interactions between presynaptic and postsynaptic cellular adhesion molecules drive synapse maturation during development. These trans-synaptic interactions are regulated by alternative splicing of cellular adhesion molecule RNAs, which ultimately determines neurotransmitter phenotype. The diverse…
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Artikel Jurnal
Vesicle Pools: Lessons from Adrenal Chromaffin Cells
The adrenal chromaffin cell serves as a model system to study fast Ca2+-dependent exocytosis. Membrane capacitance measurements in combination with Ca2+ uncaging offers a temporal resolution in the millisecond range and reveals that catecholamine release occurs in three distinct phases. Release of…
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Artikel Jurnal
Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA
Filamentous tau inclusions are hallmarks of Alzheimer’s disease (AD) and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau mediated changes in neuronal function and their possible effects on synaptic transmission are unknown. We have evaluated the effects of human…
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Artikel Jurnal
A history of spike-timing-dependent plasticity
How learning and memory is achieved in the brain is a central question in neuroscience research. Key to today’s research into information storage in the brain is the concept of synaptic plasticity, a notion that has been heavily influenced by Donald Hebb’s 1949 postulate. Hebb conjectured that…
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Artikel Jurnal
Dopamine modulates Spike Timing-Dependent Plasticity and action potential properties in CA1 pyramidal neurons of acute rat hippocampal slices
Spike Timing-Dependent Plasticity (STDP) is a cellular model of hebbian synaptic plasticity which is believed to underlie memory formation. In an attempt to establish a STDP paradigm in CA1 of acute hippocampal slices from juvenile rats (P15-20), we found that changes in excitability resulting from…
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Artikel Jurnal
GABAergic activities control spike timing- and frequency-dependent long-term depression at hippocampal excitatory synapses
GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and post-synaptic sites of hippocampal CA1 pyramidal cells differentially contribute to…
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Artikel Jurnal
Sharing vesicles between central presynaptic terminals: implications for synaptic function
Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance. In classical models of synaptic function these vesicle pools are synapse-specific, but…
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Artikel Jurnal
In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis
Spike-timing-dependent plasticity (STDP) is found in vivo in a variety of systems and species, but the first demonstrations of in vivo STDP were carried out in the optic tectum of Xenopus laevis embryos. Since then, the optic tectum has served as an excellent experimental model for studying STDP in…
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Artikel Jurnal
Temporal modulation of spike-timing-dependent plasticity
Spike-timing-dependent plasticity (STDP) has attracted considerable experimental and theoretical attention over the last decade. In the most basic formulation, STDP provides a fundamental unit- a spike pair- for quantifying the induction of long-term changes in synaptic strength. However, many…
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Artikel Jurnal
STDP in the developing sensory neocortex
Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to…
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Artikel Jurnal
Storage of phase-coded patterns via STDP in fully-connected and sparse network: a study of the network capacity
We study the storage and retrieval of phase-coded patterns as stable dynamical attractors in recurrent neural networks, for both an analog and a integrate-and-fire spiking model. The synaptic strength is determined by a learning rule based on spike-time-dependent plasticity, with an asymmetric time…