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Artikel Jurnal
Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease
Cell types rich in mitochondria, including neurons, display a high energy demand and a need for calcium buffering. The importance of mitochondria for proper neuronal function is stressed by the occurrence of neurological defects in patients suffering from a great variety of diseases caused by…
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Artikel Jurnal
Human synapses show a wide temporal window for spike-timing-dependent plasticity
Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. Synapses can bi-directionally alter strength and the magnitude and sign depend on the millisecond timing of presynaptic and postsynaptic…
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Artikel Jurnal
Control of GABA release at single mossy fiber-CA3 connections in the developing hippocampus
In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. While in adulthood MF, the axons of dentate gyrus granule cells release onto CA3 principal…
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Artikel Jurnal
Synapsin-dependent vesicle recruitment modulated by forskolin, phorbol ester and Ca2+ in mouse excitatory hippocampal synapses
Repeated release of transmitter from presynaptic elements depends on stimulus-induced Ca2+influx together with recruitment and priming of synaptic vesicles from different vesicle pools.We have compared three different manipulations of synaptic strength, all of which are knownto increase short-term…
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Artikel Jurnal
Dendritic synapse location and neocortical spike-timing-dependent plasticity
While it has been appreciated for decades that synapse location in the dendritic tree has a powerful influence on signal processing in neurons, the role of dendritic synapse location on the induction of long-term synaptic plasticity has only recently been explored. Here, we review recent work…
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Artikel Jurnal
Enhanced long term microcircuit plasticity in the valproic acid animal model of autism
A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperconnectivity of glutamatergic synapses and…
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Artikel Jurnal
Hormonal regulation of AMPA receptor trafficking and memory formation
Humans and rodents retain memories for stressful events very well. The facilitated retention of these memories is normally very useful. However, in susceptible individuals a variety of pathological conditions may develop in which memories related to stressful events remain inappropriately present…