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Artikel Jurnal
PKMζ drives spatial memory reconsolidation but not maintenance
Non-reinforced reactivation destabilizes spatial memory in the Morris water maze (MWM), triggering reconsolidation, a protein synthesis-dependent process that restabilizes reactivated memories. PKMζ is a constitutively active, atypical PKC isoform implicated in memory storage. However, the…
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Artikel Jurnal
Morphological variability may limit single-cell specificity to electric field stimulation
IntroductionNon-invasive brain stimulation techniques, widely used to manipulate neural excitability and behavior, are well studied at the meso- and macroscopic scales. However, less is known about their specificity at the level of individual cells.MethodsModels based on real pyramidal and…
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Artikel Jurnal
Synaptic transmission in supragranular layers of the human cortex – comparative review of structure, function, and plasticity
Synapses are the highly specialized connection sites between neurons enabling the establishment of complex neuronal networks. As highly plastic structures, synapses collocate both the transmission and storage of information, which is an essential prerequisite for learning and memory. Since synaptic…
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Artikel Jurnal
From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation of in vitro neural circuits
Understanding how synaptic interactions lead to circuit dynamics for neural computation requires experimental tools that can both observe and perturb neuronal activity across spatial and temporal scales. Microelectrode arrays (MEAs) provide scalable access to population spiking activity, yet they…
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Artikel Jurnal
Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux
Mitochondria regulate intracellular calcium ion (Ca2+) signaling by a fine-tuned process of mitochondrial matrix (m) Ca2+ influx, mCa2+ buffering (sequestration) and mCa2+ release (Ca2+ efflux). This process is critically important in the neurosynaptic terminal, where there is a simultaneous high…
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Artikel Jurnal
High frequency stimulation activates hot spots of spontaneous synaptic transmission
Neuronal transmitters are released at the morphological specializations known as active zones (AZs). Transmitters can be released either in response to a stimulus or spontaneously, and spontaneous transmission is a vital component of neuronal communication. Employing postsynaptically tethered…
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Artikel Jurnal
A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping
Long-term potentiation (LTP) is a biochemical process that underlies learning in excitatory glutamatergic synapses in the Central Nervous System (CNS). A critical early driver of LTP is autophosphorylation of the abundant postsynaptic enzyme, Ca2+/calmodulin-dependent protein kinase II (CaMKII)…
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Artikel Jurnal
The short-term plasticity of VIP interneurons in motor cortex
Short-term plasticity is an important feature in the brain for shaping neural dynamics and for information processing. Short-term plasticity is known to depend on many factors including brain region, cortical layer, and cell type. Here we focus on vasoactive-intestinal peptide (VIP) interneurons…
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Artikel Jurnal
Rapid sequential clustering of NMDARs, CaMKII, and AMPARs upon activation of NMDARs at developing synapses
Rapid, synapse-specific neurotransmission requires the precise alignment of presynaptic neurotransmitter release and postsynaptic receptors. How postsynaptic glutamate receptor accumulation is induced during maturation is not well understood. We find that in cultures of dissociated hippocampal…
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β-adrenergic receptor-induced E-S potentiation in the dorsal and ventral hippocampus
β-adrenergic receptors (β-ARs) play a critical role in modulating learning, memory, emotionality, and long-term synaptic plasticity. Recent studies indicate that β-ARs are necessary for long-term potentiation (LTP) induction in the ventral hippocampus under moderate synaptic activation conditions…
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Artikel Jurnal
Participation of calcium-permeable AMPA receptors in the regulation of epileptiform activity of hippocampal neurons
IntroductionEpileptiform activity is the most striking result of hyperexcitation of a group of neurons that can occur in different brain regions and then spread to other sites. Later it was shown that these rhythms have a cellular correlate in vitro called paroxysmal depolarization shift (PDS). In…
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Artikel Jurnal
Age-related changes in olivocochlear efferent innervation in gerbils
IntroductionAge-related hearing difficulties have a complex etiology that includes degenerative processes in the sensory cochlea. The cochlea comprises the start of the afferent, ascending auditory pathway, but also receives efferent feedback innervation by two separate populations of brainstem…
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Artikel Jurnal
Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), is associated with the devastating pediatric…
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Artikel Jurnal
Roles of AMPA receptors in social behaviors
As a crucial player in excitatory synaptic transmission, AMPA receptors (AMPARs) contribute to the formation, regulation, and expression of social behaviors. AMPAR modifications have been associated with naturalistic social behaviors, such as aggression, sociability, and social memory, but are also…
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Artikel Jurnal
The Wingless planar cell polarity pathway is essential for optimal activity-dependent synaptic plasticity
From fly to man, the Wingless (Wg)/Wnt signaling molecule is essential for both the stability and plasticity of the nervous system. The Drosophila neuromuscular junction (NMJ) has proven to be a useful system for deciphering the role of Wg in directing activity-dependent synaptic plasticity (ADSP)…
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Artikel Jurnal
Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I
The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as homogenous, fixed-strength units of neural communication is…