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Frontiers in Synaptic Neuroscience
Scopus
ISSN 1663-3563 · Frontiers Media S.A. · 567 articles in the index
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Journal Article
Convergence and divergence of molecular mechanisms in Hebbian and homeostatic plasticity
The umbrella of synaptic plasticity includes associative, activity-dependent alterations in synaptic strength that are thought to underlie learning and memory, and negative feedback that stabilizes network activity, termed Hebbian and homeostatic plasticity, respectively. These forms of plasticity…
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Journal Article
Spatial characterization of backpropagating action potential-evoked Ca2+ signals in human cortical layer 2/3 pyramidal neurons
IntroductionIn pyramidal neurons, backpropagating action potentials (bAPs) activate voltage-gated calcium channels (VGCCs), producing compartment-specific dendritic Ca2+ transients. While extensively characterized in rodent models, little is known about the spatial properties and channel-specific…
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Journal Article
Enhanced information processing in the human neocortex: cellular mechanisms and translational perspectives
Understanding the sophisticated cognitive abilities of the human brain requires understanding its cellular and synaptic components. While rodent studies provide foundational knowledge, recent research using freshly resected human neocortical and hippocampal tissue has revealed unanticipated…
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Journal Article
Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex
IntroductionGroup I metabotropic glutamate receptors (mGluRs) play a critical role in regulating neuronal excitability, synaptic strength, and cortical network activity. Although their physiological functions and involvement in neurological disorders are well established, direct experimental…
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Journal Article
Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation
IntroductionProgrammed axon degeneration significantly affects neural connectivity, however, the underlying mechanisms remain poorly understood, particularly in cortical regions. Sterile Alpha and TIR motif-containing protein 1 (SARM1) is a known regulator of axon degeneration in the peripheral…
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Journal Article
Rhythmic network activity in human brain slices: variability, mechanisms, and translational insights
In vitro maintained human brain slices provide a unique experimental platform for investigating rhythmic neuronal network activity, bridging the gap between animal models and clinical studies. A wide range of spontaneous and induced oscillatory activities has been described in human brain slices…
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Journal Article
Time-resolved phenotyping of seizure evolution in developmental and epileptic encephalopathy: insights and gaps from the CYFIP2 Arg87Cys mouse model
In developmental and epileptic encephalopathies (DEEs), the seizure phenotype is rarely static. Infantile epileptic spasms typically subside and are often replaced years later by other seizure types, and in several genetically defined DEEs seizure-free intervals precede seizure recurrence. Although…
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Journal Article
DHA-dominant Omega-3 compositions enhance PSD-95 organization and glutamatergic protein expression
IntroductionDocosahexaenoic acid (DHA), the predominant omega-3 (ω-3) fatty acid in the brain, which contributes to synaptic membrane organization and plasticity, is commonly recommended for brain health. However, ω-3 formulations commonly combine DHA with eicosapentaenoic acid (EPA) in varying…
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Journal Article
High-frequency, high-intensity electrical stimulation selectively activates human fast-spiking interneurons
Electrical brain stimulation has been used to treat epilepsy with therapeutic success, but without complete understanding of its cellular mechanisms of seizure suppression. Using acute human brain slices obtained from pharmaco-resistant epilepsy patients, we delivered high-frequency, high-intensity…
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Journal Article
NMDA receptors play an important role in postictal potentiation in immature rats
ObjectiveImmediate postictal potentiation (PIP), a unique phenomenon observed in immature animals, may contribute to the enhanced sensitivity of young animals to seizures and epilepsy. PIP deserves more experimental attention because understanding its mechanisms could provide valuable insights into…
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Journal Article
Mechanistic insights into the synaptic damage-repair and regeneration processes in neurodegenerative Alzheimer’s disease: phytochemicals as neuroprotective agents
Synaptic failure is one of the earliest and most significant contributors to the cognitive decline in Alzheimer’s disease (AD), preceding extensive neuronal loss. Although amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) of tau protein characterize the disease, memory impairment…
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Journal Article
Sleep disturbances as an early indicator of psychotic disorders in adolescents and young adults
Sleep disturbances are increasingly recognized as clinically relevant markers in the early detection of psychotic disorders among adolescents and young adults. These disturbances, including insomnia, circadian rhythm disruptions, parasomnias, and fragmented sleep, affect up to 70% of individuals at…
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Journal Article
Zebrafish as a translational model for peptide-mediated synaptic dysfunction related to obesity
Obesity-driven synaptic dysfunction is increasingly recognized as a key mechanism linking metabolic disorders to neurodegenerative diseases. This review aims to explore the utility of zebrafish (Danio rerio) as a translational model to investigate these mechanisms and screen peptide-based…
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Journal Article
Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation
Silent synapses represent a unique class of synaptic connections that are non-functional at rest but possess the potential to become functional, serving as a critical reservoir for neural plasticity. Their activation mechanisms not only challenge traditional models of synaptic maturation but also…
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Journal Article
The how and why for multiple forms of hippocampal LTP
Activity-induced Long-Term Potentiation (LTP)—characterized as it is by rapid induction, synapse specificity, and remarkable persistence—has long been considered a primary substrate for memory encoding. There has however been considerable debate about the cellular mechanisms responsible for…