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Artikel Jurnal
No evidence that serum metabolite slopes improve held-out prediction of clinical progression in the Alzheimer’s disease neuroimaging initiative
BackgroundRepeated serum metabolite measurements may contribute to predicting clinical progression, but their incremental value requires evaluation beyond established clinical predictors.MethodsWe linked Alzheimer’s Disease Neuroimaging Initiative (ADNI) clinical data to Biocrates Quant 500 serum…
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Artikel Jurnal
Repeated plantar electrical stimulation is associated with altered lower-limb somatosensory processing in older adults: evidence from somatosensory evoked potentials
IntroductionAge-related declines in lower-limb somatosensory function may contribute to impaired motor control and increased fall risk in older adults. Although plantar sensory stimulation has been reported to improve postural control, its effects on neural processing remain unclear. This study…
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Artikel Jurnal
Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Parkinson’s disease patients with subjective cognitive decline
IntroductionThis study aimed to examine diffusion alterations indexed by the diffusion tensor image analysis along the perivascular space (DTI-ALPS) in patients with Parkinson’s disease presenting with subjective cognitive decline (PD-SCD), and to investigate their associations with impairments…
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Artikel Jurnal
Theta-frequency subthalamic nucleus deep brain stimulation selectively improves visual attention in Parkinson’s disease
ObjectiveVisual attention deficits are common but under-recognized in Parkinson’s disease (PD), and we investigate whether theta-frequency (5 Hz) STN-DBS differentially modulates visual attention compared with high-frequency (130 Hz) stimulation in PD patients.MethodsThirty-nine PD patients with…
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Artikel Jurnal
Factors associated with self- perceived speech impairment in de novo Parkinson’s disease: a retrospective study of an international database
IntroductionPeople with Parkinson’s disease (PwPD) may experience speech changes early in the disease process, yet it is unclear how they perceive them. Moreover, in de novo PD specifically, the relationship between speech, cognition, and swallowing is not well-established. Therefore, this study…
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Artikel Jurnal
Age-group differences in diffusion MRI characteristics of cortico-cerebellar tracts and their association with bimanual performance
IntroductionAging is associated with alterations in white matter structure and decline in bimanual performance. These parallel changes may be interrelated, as previous studies have linked cerebral white matter properties to both motor and cognitive function. The cerebellum plays a central role in…
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Artikel Jurnal
Reproductive life stages and cognitive outcomes: a systematic review in Latin American and Caribbean women
Reproductive life stages, menopausal symptoms, and hormonal exposures are increasingly recognized as potential determinants of cognitive outcomes in women. However, these associations remain largely understudied in Latin American and Caribbean (LAC) populations. In this systematic review, we…
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Artikel Jurnal
Distinct brain activation patterns linked to clinical symptoms during hand grasping in Parkinson's disease
ObjectiveThis study aimed to investigate the characteristics of brain functional activation during a hand grasping task in patients with Parkinson's Disease (PD) using functional near-infrared spectroscopy (fNIRS), and to further explore the clinical factors associated with the level of regional…
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Artikel Jurnal
Global research architecture of RNA-binding proteins in neurodegenerative diseases: a web of science bibliometric study with PubMed record verification, 2001–2025
BackgroundRNA-binding proteins (RBPs) connect RNA homeostasis to proteostasis and selective neuronal vulnerability, but the organization and evolution of this cross-disease research field remain unclear.MethodsWe analyzed Web of Science Core Collection (WoSCC) records published through 2025. PubMed…
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Artikel Jurnal
Associations between cerebrospinal fluid biomarkers related to endothelial dysfunction and Alzheimer’s disease
BackgroundAlthough associations between overt vascular injury and Alzheimer’s disease (AD) have been reported, the role of subclinical vascular injury in dementia pathogenesis remains unclear. Cerebrospinal fluid (CSF) biomarkers related to endothelial dysfunction may capture subclinical vascular…
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Artikel Jurnal
Neuropeptide Y and brain ageing: an updated scoping review on the role of autophagy
Brain ageing is a complex physiological process characterised by progressive structural and functional changes that often result in cognitive decline and reduced quality of life in the elderly. These changes are driven by multiple mechanisms, including synaptic dysfunction, oxidative stress…
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Artikel Jurnal
Effects of multicomponent exercise on global cognitive function, executive function, and brain-derived neurotrophic factors in older adults with mild cognitive impairment: a systematic review and three-level meta-analysis
ObjectiveTo systematically evaluate the effects of multicomponent exercise on global cognitive function, executive function, and brain-derived neurotrophic factor in older adults with mild cognitive impairment using a three-level meta-analysis.MethodsWeb of Science, Cochrane Library, Embase…
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Artikel Jurnal
Burden-dependent associations of serum sTREM2 with white matter injury and cognitive heterogeneity in cerebral small vessel disease
ObjectiveCognitive outcomes vary among individuals with cerebral small vessel disease (CSVD), and conventional imaging markers may not fully explain this heterogeneity. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is involved in TREM2-related myeloid responses, but the clinical…
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Artikel Jurnal
Effects of dual-task training on health-related quality of life and cognitive function in people with Parkinson’s disease: a systematic review and meta-analysis
IntroductionDual-task training is proposed as a rehabilitative strategy to mitigate motor and cognitive impairments in patients with Parkinson’s disease (PD). This systematic review and meta-analysis sought to consolidate existing information regarding the impact of dual-task therapies on…
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Effects of globus pallidus internus deep brain stimulation on freezing of gait in Parkinson's disease: a prospective short-term single-arm study
BackgroundFreezing of gait (FoG) is a debilitating symptom in Parkinson's disease (PD), often resistant to medication. Deep brain stimulation (DBS) has emerged as an effective treatment for advanced PD, while its effect on FoG remains inconsistent. Specifically, the effect of globus pallidus…
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Home-administered unfocused transcranial ultrasound in subjective cognitive decline and dementia: an open-label, uncontrolled feasibility pilot study
BackgroundMemory and cognitive impairments remain disabling, with few effective treatments. Low-intensity transcranial ultrasound (TUS) is a non-invasive neuromodulation approach with a favorable safety profile and preliminary evidence of cognitive benefit, with one hypothesized but unproven…
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Unraveling changes in mitochondrial processes influenced by ancestry in APOEε4 carriers with Alzheimer disease
IntroductionThe APOEε4 allele is the strongest known genetic risk factor for late-onset Alzheimer disease (AD). However, the risk effect of APOEε4 varies substantially by ancestry, with individuals of African ancestry (AF) demonstrating markedly lower risk compared to those of European ancestry…
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Plasma p-tau181 moderates the association between ten-year atherosclerotic cardiovascular disease risk and mild cognitive impairment – HABS-HD
IntroductionThis study examined cross-sectional associations between ten-year American Heart Association (AHA) atherosclerotic cardiovascular disease (ASCVD) risk and plasma Alzheimer’s disease (AD) biomarkers in relation to cognitive outcomes and to determine whether ASCVD risk modifies…
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Artikel Jurnal
Plasma biomarker strategies to reduce diagnostic uncertainty in p-tau217–based assessment of CSF amyloid positivity in secondary-care patients with MCI
IntroductionPlasma p-tau217 accurately reflects amyloid pathology, but dual-cutoff strategies leave a non-negligible grey zone requiring confirmatory testing. We evaluated whether integrating plasma Aβ measurements could reduce diagnostic uncertainty in patients with mild cognitive impairment…
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Artikel Jurnal
Evaluation of peripheral and intranigral AAV-mediated Irisin delivery in a chronic AAV-A53T α-Synuclein overexpression mouse model of Parkinson’s disease
BackgroundParkinson’s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra and pathological aggregation of α-Synuclein (α-Syn). Although Irisin has shown neuroprotective effects in acute MPTP-induced and α-Syn preformed fibrils (PFFs) propagation models…
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