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Artikel Jurnal
Risk factors associated with cancer and metabolic encephalopathy in Alzheimer’s disease patients
BackgroundAlzheimer’s disease (AD) frequently coexists with risk factors that modify its clinical course. The combined presence of cancer and metabolic encephalopathy (ME) in AD represents a particularly vulnerable and understudied phenotype. We investigated whether cancer-associated risk profiles…
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Engagement with the national electronic health records by people with Parkinson's disease
BackgroundPeople with Parkinson's disease (PwPD) require coordinated, multidisciplinary care, which can be facilitated by Electronic Health Records (EHRs) enabling efficient information exchange and personalized decision-making. Understanding which patient-, healthcare provider- (HCP), and…
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Regional brain and cerebrovasculature morphology during normative aging in male and female C57BL/6N mice
IntroductionNormative aging is the process of gradual physical, cognitive and biological changes that occur with advancing age. This contrasts to pathological processes, such as neurodegeneration where changes are accelerated and more pronounced. Brain morphology and its cerebrovasculature are…
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Selective amygdala subregional atrophy in Parkinson’s disease: from subjective cognitive decline to mild cognitive impairment
BackgroundCognitive impairment is a common and disabling non-motor feature of Parkinson’s disease (PD). Subjective cognitive decline (SCD) has been proposed as an early clinical stage of cognitive dysfunction in PD; however, its neuroanatomical correlates remain poorly defined. The amygdala is an…
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Mechanisms and disease associations of oxidative stress-mediated brain-bone axis dysregulation: a knowledge mapping and trend analysis based on Bibliometrics
BackgroundOxidative stress, characterized by the systemic imbalance between reactive oxygen species and antioxidant defenses, is increasingly recognized as a central pathological nexus driving the dysregulation of the brain-bone axis. Despite the accumulation of empirical evidence, a systematic…
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Trajectories and timing of accelerated decline in specific memory domains preceding Alzheimer’s disease
IntroductionMemory impairment is a hallmark feature of Alzheimer’s disease (AD) and may emerge years before clinical diagnosis. However, the temporal sequence and acceleration patterns of decline across specific memory domains during the preclinical stage remain incompletely understood. This study…
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The role of exercise intensity in motor and non-motor symptoms of Parkinson's disease: mechanisms, clinical evidence, and personalized exercise prescription parameters
Parkinson's disease (PD) is the second most common neurodegenerative disorder, featuring progressive dopaminergic neuronal loss, Lewy body (LB) pathology, and a broad spectrum of motor and non-motor symptoms. Although dopaminergic pharmacotherapy remains the cornerstone of symptomatic treatment…
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Social cognition in Parkinson’s disease: a comprehensive systematic review and integrative conceptual framework
IntroductionParkinson’s disease (PD) is characterized not only by motor symptoms but also by non-motor impairments, including deficits in social cognition (SC), defined as the ability to recognize, interpret, and respond to others’ emotions, intentions, and behaviors. This systematic review…
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Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer’s disease mice by remodeling gut microbiota and host serum metabolites
Alzheimer’s disease (AD), with the most prominent pathological feature of the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau proteins (P-tau), is the foremost cause of dementia. Ershiwuwei Shanhu Pill (ESP) is commonly used in clinical practice in…
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Behind the scenes of a 7T MRI clinical study in Alzheimer's disease: challenges and recommendations for future research
Combining pharmacological interventions with neuroimaging in Alzheimer's disease (AD) research presents logistical and methodological challengesparticularly during early study phases, such as recruitment and study visits. Yet, these challenges are rarely reported in detail. This perspective article…
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Age-associated neuronal micronuclei formation and transfer to microglia
Microglia, the resident immune cells of the central nervous system, dynamically respond to signals from their microenvironment, including adjacent neurons. Among these signals, nuclear contents released from damaged neurons have been implicated in triggering inflammatory microglial responses…
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Motor performance and 3D gait pattern characteristics in older adult women with early mild cognitive impairment: a pilot study
IntroductionEarly mild cognitive impairment (eMCI) is often accompanied by subtle alterations in motor function and gait control before the onset of overt dementia. Identifying these early functional changes may provide useful information for early detection and intervention. This study compared…
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State sensitivity and five-year longitudinal stability of resting-state EEG biomarker candidates in healthy adults
Resting-state EEG is widely used to investigate individual differences in brain function, as it allows repeated measurements with high temporal resolution and minimal task demands. However, validating EEG metrics as biomarker candidates requires more than demonstrating cross-sectional differences…
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Deciphering MMRN1 diagnostic and therapeutic implications in the substantia nigra of Parkinson’s disease patients via integrative bioinformatic analysis and multi-omics studies
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN), primarily due to α-synuclein aggregation, posing a major health threat to the elderly population. Current treatment options remain limited…
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FLOT1 and EEF1D: ac4C-related genes bridging Alzheimer’s disease and sleep deprivation
BackgroundAlzheimer’s disease (AD) and sleep deprivation (SD), two common conditions in the elderly, share complex molecular connections and may mutually influence each other’s pathogenesis. Current drugs only relieve symptoms with limited efficacy, making it urgent to explore the shared…
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Striatal functional connectivity alterations in mild cognitive impairment subtypes defined by CSF A/T biomarkers
BackgroundMild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s disease (AD), the primary cause of dementia. In addition to supporting motor and higher-order cognitive activities, the basal ganglia, particularly the caudate nucleus and putamen, may exhibit early AD-related network…
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Brain over muscle: central mechanisms predominate in gait impairment among older adults with type 2 diabetes mellitus
BackgroundGait impairment is common in older adults with type 2 diabetes mellitus (T2DM). This complication increases risk of falls, disability, and mortality. Although gait disorders are often associated with peripheral deficits, emerging evidence suggests that central mechanisms may play an…
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Examining of the mechanism by which Yin Huang Ge compound alleviates cognitive dysfunction in Alzheimer’s disease mice through modulation of Aβ degrading enzymes and neurotrophic factors
BackgroundAlzheimer’s disease (AD) poses a significant threat to human health, and with the number of patients increasing annually, developing effective prevention and treatment strategies has become an urgent priority. Early intervention is a viable strategy for treating AD, as biomarker changes…
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Artikel Jurnal
Effects of acupuncture on cognitive function and lipid metabolism in post-stroke vascular dementia: a systematic review and meta-analysis of randomized controlled trials
IntroductionPost-stroke vascular dementia (PSVD) is a prevalent cognitive disorder and an underexplored area in dementia research, yet conventional pharmacotherapies have limited efficacy. Although acupuncture has emerged as a promising non-pharmacological intervention, no systematic review has…
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