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Artikel Jurnal
Effects of aging on recognition and dominance perception in laughter
IntroductionAging is associated with reduced accuracy in recognizing others’ emotions, an ability that is important for maintaining social connectedness in later life. Laughter is a social signal with multiple functions, as it can facilitate social bonding but also convey negative social meanings…
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Artikel Jurnal
Sphingolipids associated research in Alzheimer’s disease: an explored trends analysis
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment. Numerous studies have indicated that dysregulation of sphingolipid metabolism is closely associated with the core pathology of AD and acts as a crucial driving factor. This study…
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Artikel Jurnal
Age-dependent vulnerability to spatial memory interference in APP/PS1 mice
BackgroundWhile Alzheimer’s disease (AD) is well known for progressive memory impairment, less is understood about how amyloid pathology affects flexible updating of competing spatial representations. Here, we used the Objects in Updated Locations (OUL) paradigm to investigate how amyloidosis…
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APOE4 accelerates menopause-associated brain metabolic shift and disrupts bioenergetic adaptation
IntroductionDisruption of brain glucose and lipid metabolism contributes to Alzheimer’s disease (AD) and often emerges before clinical symptoms. Women are at increased AD risk due to menopause-associated estrogen decline, which impairs mitochondrial function and glucose metabolism. Women’s risk of…
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Artikel Jurnal
Imaging biomarkers of glymphatic system dysfunction in Alzheimer’s disease: a systematic review and meta-analysis with a focus on DTI-ALPS index
BackgroundAlzheimer’s disease (AD) has been linked to impaired clearance of metabolic waste, and glymphatic dysfunction is increasingly considered a potential contributor to its pathogenesis. The diffusion tensor imaging-based analysis along the perivascular space (ALPS) index has been proposed as…
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Artikel Jurnal
Neural frequency-tagging of syllables in naturalistic speech is sensitive to background noise and age-related hearing loss
IntroductionHealthy aging is often accompanied by a loss of hearing sensitivity and a reduced ability to understand speech in both quiet and noisy environments. From a physiological perspective, neural oscillations are thought to fundamentally contribute to parse the speech signal into meaningful…
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Artikel Jurnal
Distinct aging-related profiles of allocentric knowledge recall following navigation in an immersive, naturalistic, city-like environment
Aging-related declines in spatial navigation pose significant challenges for older adults’ independence and quality of life. Among navigational deficits, older adults have been shown to demonstrate deficits in utilizing allocentric (i.e., world-centered) information and rely on egocentric (i.e…
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Artikel Jurnal
Serum BP180 and BP230 autoantibodies in Alzheimer’s disease: diagnostic and cognitive associations in a retrospective study
BackgroundTo assess the prevalence and diagnostic value of serum anti-BP180 and anti-BP230 antibodies in Alzheimer’s Disease (AD) and their relationship with cognitive function.MethodsWe conducted a retrospective case–control study comprising 279 participants, including patients with clinically…
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Artikel Jurnal
Overcoming the diagnostic gap in mild cognitive impairment in Parkinson’s disease: a pilot study employing a machine learning-/augmented reality-based digital biomarker
BackgroundCognitive impairment is a clinically significant, non-motor symptom of Parkinson’s disease (PD) commonly associated with reduced quality of life, increased caregiver burden, and higher risk of progression to dementia. Mild cognitive impairment in PD (PD-MCI) is expressed heterogeneously…
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Analysis of structural alterations in olfactory-related brain regions in patients with cognitive impairment and the correlation with olfactory function
ObjectiveTo evaluate the differences in olfactory function, volumes of brain regions related to olfaction, and subregion volumes of the amygdala and hippocampus among the healthy control (HC), mild cognitive impairment (MCI), and Alzheimer’s disease (AD), as well as the association of volumes and…
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Artikel Jurnal
ZBTB7A-mediated regulation of astrocytic glycolysis in neurodegenerative diseases: insights from literature review and bioinformatics prediction
The incidence of neurodegenerative diseases, including Alzheimer’s disease (AD), continues to increase with the extension of human lifespan. However, their pathogenesis remains incompletely understood. Altered energy metabolism, particularly glucose metabolism involving glycolysis and oxidative…
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Artikel Jurnal
Non-invasive brain stimulation in frontotemporal dementia: syndrome-specific signals and priorities for future trials
Frontotemporal dementia is the second most common cause of young-onset dementia after Alzheimer’s disease and lacks disease-modifying treatment. This narrative review summarizes human studies of non-invasive brain stimulation, including repetitive transcranial magnetic stimulation and theta-burst…
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Artikel Jurnal
Rethinking PINK1/Parkin-mediated mitophagy in Parkinson’s disease: functional continuity and activation–clearance uncoupling
Mitochondrial dysfunction is a central feature of Parkinson’s disease (PD) and contributes to the selective vulnerability of nigral dopaminergic (DA) neurons. Among the pathways that maintain mitochondrial integrity, PINK1/Parkin-mediated mitophagy has been extensively characterized as a…
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Artikel Jurnal
Generic vs. brand-name pramipexole: effectiveness, safety, and cost comparison in a multicenter retrospective cohort study
BackgroundGeneric pramipexole is widely prescribed for Parkinson’s disease (PD), yet clinical equivalence to the brand-name formulation remains debated. We aimed to compare generic and brand-name pramipexole dihydrochloride tablets in real world.MethodsWe conducted a multicenter retrospective…
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Artikel Jurnal
The amino acid substitutions A30W, K28A, and M35C alter amyloid-β peptide toxicity in cell culture and in an in vivo model of amyloidosis in Caenorhabditis elegans
The buildup of toxic aggregates formed by the amyloid-β peptide 1–42 (Aβ42) is a central process in Alzheimer’s disease (AD) pathology. The peptide’s self-assembly and toxicity are highly dependent on its primary amino acid sequence and can be altered by modifying key residues. Specifically, the…
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Artikel Jurnal
Short-term neurovascular and electrophysiological responses to combined visual and vibration stimulation in older adults with mild cognitive impairment
Mild cognitive impairment (MCI) is associated with age-related alterations in neural oscillatory activity and cerebral hemodynamics, while mobility limitations often restrict participation in conventional exercise-based interventions. This study investigated exploratory, single-arm, within-subject…
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Artikel Jurnal
Searching for a needle in a haystack—ambulatory research in Parkinson’s disease in Germany
BackgroundParkinson’s disease (PD) is a prevalent neurodegenerative disorder with a rapidly increasing incidence worldwide and complex treatment requirements. It is predominantly treated on an outpatient basis. However, detailed clinical data from outpatient practice remain scarce. We therefore set…
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Plasma miR-34a-5p outperforms miR-126-3p in predicting cognitive decline in cerebral small vessel disease patients with impaired glucose regulation
IntroductionMicroRNAs (miRNAs) are promising biomarkers for the diagnosis and prognosis of neurodegenerative diseases. Over the past few years, miR-34a-5p and miR-126-3p have become some of the most characterized miRNA, the former being associated with cellular senescence and apoptosis and the…
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Artikel Jurnal
Protective effect of baicalein from Pinellia ternate on Alzheimer’s disease cell injury: a network pharmacology, molecular docking, and molecular dynamics study
IntroductionAlzheimer’s disease (AD) constitutes the primary leading cause of dementia. Pinellia ternata (Thunb.) Breit. is a traditional Chinese herb with unclarified potential therapeutic effects against AD. This study aimed to explore the therapeutic potential and underlying mechanism of…
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