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Artikel Jurnal
Clinical and neuroimaging correlates of motoric cognitive risk syndrome in cerebral small vessel disease: a cross-sectional study
IntroductionCerebral small vessel disease (CSVD) and motoric cognitive risk syndrome (MCR) are both associated with adverse outcomes in older adults. Factors associated with MCR in CSVD remain poorly understood. We aimed to explore factors associated with MCR and its components (slow gait and…
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Artikel Jurnal
The predictive power of neuropsychological measures in MCI: early detection of dementia conversion
BackgroundWith rising global life expectancy, early identification of dementia risk is crucial for implementing timely interventions. This study assesses the value of neuropsychological measures in stratifying the risk of mild cognitive impairment (MCI) progression over a 3 years period.MethodsThis…
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Artikel Jurnal
From clinical phenotypes to molecular stratification: early differential diagnosis of four-repeat tauopathies
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are primary tauopathies defined by aggregation of four-repeat (4R) tau, yet early in vivo diagnosis remains limited by the dissociation between clinical phenotype and molecular pathology. Clinical presentations are…
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High-saturated-fat diet drives female-biased neurodegeneration in Drosophila via oxidative stress and impaired autophagic flux
ObjectiveDietary saturated fat intake has been increasingly linked to dementia risk, yet the mechanisms through which high-fat diets (HFDs) compromise neuronal integrity remain poorly defined. The model organism Drosophila melanogaster may serve as an ideal model to understand these mechanisms…
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Artikel Jurnal
Associations of cerebrospinal fluid measures of synaptic function with white matter microstructure and cognition in older adults
IntroductionLower levels of several synaptic proteins in cerebrospinal fluid (CSF) have been associated with greater cognitive decline among older adults, but there is limited understanding of their associations with brain structure. This study is among the first to examine the cross-sectional…
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Artikel Jurnal
Plasma Aβ42/p-Tau217 ratio and p-Tau217 independently predict CSF-defined Alzheimer’s disease pathology in a Brazilian admixed cohort
IntroductionBlood-based biomarkers offer a promising, minimally invasive approach to Alzheimer’s disease (AD) diagnosis, yet validation in admixed populations remains limited. We investigated whether plasma biomarkers predict CSF-defined AD pathology in a Brazilian cohort.MethodsSeventy-eight older…
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Artikel Jurnal
Cognitive correlates of decision-making in Parkinson’s disease: a systematic review
IntroductionChanges in decision-making (DM) are frequently observed in patients with Parkinson’s disease (PD). Despite extensive research, the relationships between DM and various cognitive functions remain incompletely understood. This systematic review aims to synthesize existing evidence on the…
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Artikel Jurnal
Evaluation of the association between MREPT-derived conductivity and IVIM-derived ISF-related metrics in the brains of patients with cognitive impairments
BackgroundAlterations in the ionic microenvironment and interstitial fluid (ISF) dynamics are increasingly recognized as early pathological events in Alzheimer’s disease (AD). However, the in vivo relationship between bulk tissue electrical properties and ISF mobility remains unclear.PurposeThis…
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Artikel Jurnal
Sustained attention in dementia with Lewy bodies: a task-based fMRI study
IntroductionPatients with Dementia with Lewy Bodies (DLB) typically experience attentional deficits. Understanding these deficits and the underlying neural correlates is crucial as sustained attention supports higher level cognitive functions. The objective of this study was to investigate the…
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Artikel Jurnal
From artery to memory: a comparative review of vascular cognitive impairment surgical models
Vascular cognitive impairment (VCI) encompasses a spectrum of cerebrovascular diseases ranging from mild clinical cognitive impairment to advanced vascular dementia and is recognized as a major contributor to the global dementia burden. Frequently coexisting with Alzheimer’s Disease (AD), VCI…
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Artikel Jurnal
High-density EEG network analysis in MCI: an exploratory study of electrode density and cognitive performance
IntroductionElectroencephalography-derived functional connectivity and graph-theoretical measures are increasingly investigated as markers of cognitive dysfunction in mild cognitive impairment, but the extent to which their clinical sensitivity depends on electrode density remains unclear. This…
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Artikel Jurnal
Transsynaptic complex dysfunction in the hippocampus of Alzheimer’s disease patients
IntroductionAlzheimer’s disease (AD) involves not only amyloid-β and tau pathology but synaptic dysfunction and impaired autophagy, though the underlying mechanisms and their relationship to AD progression are not well understood. Transsynaptic complexes involving presynaptic neurexins (Nrxn1/2/3)…
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Artikel Jurnal
Distinct neurostructural, cognitive, and neuropsychiatric associations of plasma p-tau217, and Aβ42/40 in Parkinson’s disease and aging cohorts
ObjectiveAlzheimer’s disease (AD) co-pathology may contribute to cognitive decline and faster progression in Parkinson’s disease (PD). Although blood-based biomarkers enable biological staging along the AD continuum, their contribution in the clinical-biological characterization of PD phenotypes…
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Artikel Jurnal
The different stimulation durations of transcranial direct current stimulation for Parkinson’s disease: a systematic review and network meta-analysis
BackgroundTranscranial direct current stimulation (tDCS) holds promise for the treatment of motor symptoms in Parkinson’s disease (PD). However, the optimal stimulation duration within a single session remains unclear.ObjectiveThis network meta-analysis (NMA) aimed to compare the relative effects…
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Artikel Jurnal
SVIP in plasma: a candidate blood-based biomarker for early detection of amnestic mild cognitive impairment
BackgroundAmnestic mild cognitive impairment (aMCI) represents a critical clinical window for early intervention in Alzheimer’s disease (AD). Identifying readily detectable, high-abundance plasma biomarkers for aMCI remains clinically important. Overexpression of Valosin-Containing Protein (VCP)…
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Artikel Jurnal
Mitochondrial dysfunction in Alzheimer’s disease: connecting pathophysiology with neuroimaging
Alzheimer’s disease (AD), primarily characterized by progressive cognitive decline, poses a significant global public health challenge. Emerging evidence indicates that mitochondrial dysfunction plays a central role in AD-related neurodegeneration. This dysfunction manifests as impaired energy…
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Artikel Jurnal
Multiple system atrophy: integrating clinical phenotypes and multimodal biomarkers for early diagnosis
Multiple system atrophy is a rare and rapidly progressive synucleinopathy characterized by parkinsonism, cerebellar ataxia, and prominent autonomic dysfunction. Neuropathological findings include misfolded α-synuclein accumulation in oligodendrocytes and neuronal loss leading to multisystem…
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Artikel Jurnal
Gerobiotics and neuroprotection: effects on the gut-brain axis in age-related neurodegenerative diseases
As the global population ages, effective strategies to attenuate or prevent neurodegenerative processes are becoming increasingly important. Gerobiotics, an emerging class of probiotic strains and their derived postbiotics, are considered promising geroprotective agents because of their potential…
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