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Artikel Jurnal
Propranolol reinstates mitochondrial dynamics and synaptic memory pathways through CaMKII/CREB–BDNF/ PKMζ cascades in an AD-like rat model
BackgroundAlzheimer’s disease (AD) is a major neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, neurofibrillary tangles, and progressive cognitive decline. Despite significant advances in understanding its pathophysiology, current therapeutic options provide limited…
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Artikel Jurnal
Risk factors and development of a prediction model for hematoma expansion in elderly patients with spontaneous intracerebral hemorrhage
BackgroundHematoma expansion (HE) is a major determinant of early neurological deterioration after spontaneous intracerebral hemorrhage (sICH) in older adults. We aimed to identify independent risk factors for HE and to develop a predictive model for elderly patients with sICH.MethodsThis…
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Relationship between high-sensitivity C-reactive protein/lymphocyte ratio and post-thrombolysis short-term outcome in acute ischemic stroke patients
ObjectivesHigh-sensitivity C-reactive protein / lymphocyte ratio (hsCLR) was emerged as a promising novel biomarker for various diseases. However, the relationship between hsCLR and short-term outcome in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) remained…
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Artikel Jurnal
Physical activity patterns, genetic susceptibility, and incident ischemic stroke: a population-based cohort study
BackgroundIschemic stroke is a leading cause of death and disability worldwide. Whether different weekly physical activity patterns confer similar protection remains unclear, and genetic susceptibility may further influence risk. We therefore examined the associations of physical activity pattern…
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Artikel Jurnal
Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects
Tinnitus, a prevalent auditory perception symptom, is closely associated with maladaptive neuroplasticity within the central auditory and non-auditory pathways. Its complex pathophysiology shares significant mechanistic parallels with neurodegenerative processes, including neuroinflammation…
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Artikel Jurnal
The Green Parkinson’s Belt: agricultural regions associated with increased Parkinson’s disease burden in Mexico
BackgroundParkinson’s disease (PD) is projected to increase substantially in Mexico over coming decades, yet its geographic distribution has not been systematically examined at the state level. This study aimed to evaluate whether PD prevalence in Mexico exhibits geographic clustering, with…
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Artikel Jurnal
Effects of Liuzijue Qigong on respiratory function, trunk control, and balance after stroke: a randomized controlled trial
PurposeTo evaluate the effects of adding Liuzijue Qigong (LQG) to standard rehabilitation on respiratory function, trunk control, and balance after stroke, and to explore a possible respiratory-core-balance pathway.Materials and methodsIn this assessor-blinded randomized controlled trial, 120…
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Artikel Jurnal
Needle-warming moxibustion alleviates pain in rats with cervical spondylotic radiculopathy by modulating the NF-κB/ROS/NLRP3 pathway
AimThis study investigates the effects of needle-warming moxibustion (NWM) on cervical spondylotic radiculopathy (CSR) by regulating the activation of the nuclear factor-kappa B (NF-κB) pathway.MethodsA CSR rat model was prepared using the fish wire extrusion method and administered postoperative…
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Lateralization of interictal epileptiform discharges differently impacts cognitive performance and behavior in late-onset epilepsy of unknown aetiology
BackgroundLate-onset epilepsy of unknown aetiology (LOEU) is increasingly recognized as a multifactorial condition potentially linked to preclinical neurodegeneration. Despite its clinical relevance, the impact of lateralized interictal epileptiform discharges (IEDs) on cognitive and behavioral…
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Intracerebroventricular infusion of exercise donor plasma exosomes induces molecular changes indicating exercise-like adaptations in basal ganglia cells of older male rats
Chronic moderate aerobic exercise promotes health in older adults and provides neuroprotection to patients with neurodegenerative diseases, most notably Parkinson’s disease (PD). Exosomes are small extracellular vesicles that facilitate interorgan communication. During exercise, they are…
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Artikel Jurnal
Integrating memory-guided saccades and EEG for MCI screening: a multimodal LASSO modeling approach
BackgroundWe investigated differences in memory-guided saccades (MGS) and electroencephalographic (EEG) spectral ratios between cognitively normal older adults and patients with mild cognitive impairment (MCI). A multimodal predictive model was developed to evaluate its potential for early MCI…
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Artikel Jurnal
Near-gaze fixation promotes use of spin turns during walking: age-independent visuomotor effects with maladaptive behavioral consequences in older adults
BackgroundOlder adults frequently rely on spin turns while walking, a turning strategy that is biomechanically less stable than step turns and has been associated with an increased risk of falls. Previous studies have suggested that increased gaze fixation toward the area near the feet may be…
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Artikel Jurnal
Diagnostic performance of plasma p-Tau217, p-Tau181, and p-Tau231 across the Alzheimer’s disease continuum: a network meta-analysis
ImportanceBlood-based biomarkers (BBMs) are transforming the diagnostic workflow for Alzheimer’s disease (AD). However, there is no consensus on the optimal phosphorylated tau (p-tau) isoform (217, 181, or 231) or analytical platform [mass spectrometry (MS) vs. immunoassay (IA)] for clinical…
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Artikel Jurnal
Proteomic profiling of olfactory exfoliates from people with subjective cognitive complaints reveal networks of olfactory biomarkers of cognitive performance
IntroductionPartly due to the inaccessibility of olfactory brain regions vulnerable to early Alzheimer’s Disease (AD) for repeated sampling, proteomic networks underlying progressive cognitive decline remain poorly understood. The olfactory mucosa (OM), an accessible part of the olfactory system…
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Artikel Jurnal
Systemic inflammatory index correlates with cerebral small vessel disease in Parkinson’s disease
BackgroundThis study investigates the association between systemic inflammatory indices—specifically, the systemic immune inflammation index (SII) and systemic inflammation response index (SIRI)—and the severity of cerebral small vessel disease (CSVD) in patients with Parkinson’s disease…
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Artikel Jurnal
The role of energy deficit in autophagy failure in Parkinson’s disease
Mitochondrial complex I dysfunction, ATP depletion, and impaired autophagy are key features of Parkinson’s disease (PD), but their causal relationship remains unclear. Although energy stress induces autophagy, autophagy execution requires ATP. Available evidence suggests a biphasic effect of ATP…
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Artikel Jurnal
Plasma lncRNA signature of upregulated ATP2B1-AS1 and downregulated RPL21P28 correlates with diagnosis and cognitive severity in Alzheimer’s disease
BackgroundThe non-invasive biomarkers have considerable effects in determination and treatment of Alzheimer’s disease (AD). The specificity and stability of the circulating long non-coding RNAs (lncRNAs) have made them suitable options in disease management. The aim of this study was discovering…
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Artikel Jurnal
H-ferritin nanoparticle-mediated antibody delivery across the blood-brain barrier
BackgroundTherapeutic monoclonal antibodies (mAbs) show great promise for treating neurological disorders thanks to their high selectivity and potency. However, their clinical potential is significantly limited by poor penetration across the blood-brain barrier (BBB). It has been shown that…
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Artikel Jurnal
Distinct migration patterns of adult neural stem cells derived from hippocampal and ventricular niches
Adult neurogenesis occurs in the two primary areas of the human brain, namely the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles. Neural stem cells (NSCs) from these niches generate new neurons and glia that contribute to plasticity and repair…
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Artikel Jurnal
Unraveling the role of HIF-1 in peripheral blood mononuclear cells from older patients with Alzheimer’s disease
IntroductionCerebrovascular damage is increasingly recognized as an early event in the dementia continuum, occurring before typical Alzheimer’s disease (AD) pathological changes. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor composed of HIF-1α and HIF-1β subunits which, under hypoxic…
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