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Artikel Jurnal
Music activities that most elicit interest and pleasure among older people with mild-to-moderate dementia: a qualitative multiple-case study in Italy
Literature has well documented the impact of music on the mood of older adults with dementia and underscored that the pleasantness of activities may increase the intervention’s efficacy. Nevertheless, it is unclear which music activities may be more effective in triggering interest and pleasure in…
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Artikel Jurnal
Chronic nicotine reverses age-related decline of interneuron markers in mouse auditory cortex
Inhibition in central auditory pathways declines in old age, which contributes to age-related auditory processing deficits. In auditory cortex, most inhibitory interneurons can be identified by one of three marker proteins: parvalbumin (PV), somatostatin (SOM), or vasoactive intestinal peptide…
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Artikel Jurnal
Brain metabolic and network profiles characterized by comorbid depressive symptoms and sleep disturbances in Parkinson’s disease: an 18F-FDG PET study
BackgroundParkinson’s disease (PD) is a globally increasing neurodegenerative disorder. Its complex, multisystem pathophysiology extends beyond dopaminergic neuron loss and gives rise to diverse clinical manifestations. This exploratory study examined brain metabolic patterns in patients with PD…
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Artikel Jurnal
Sleep–neuroinflammation interactions in Alzheimer’s disease: a systematic review of biomarker pathways
Although sleep disturbances are increasingly associated with Alzheimer’s disease (AD), the mechanistic interplay between sleep physiology, neuroinflammation and AD-related pathology is not fully understood. The question of whether disrupted sleep contributes to neurodegeneration or merely reflects…
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Artikel Jurnal
Cognitive ageing among older Latin American immigrants: current evidence and limitations
ObjectiveThis review synthesises current evidence on cognitive function among older Latin American immigrants and identifies key factors associated with cognitive outcomes.MethodsFollowing PRISMA guidelines, a systematic search was conducted across five databases (Embase, PubMed, Web of Science…
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Artikel Jurnal
AAV-mediated gene therapy for Alzheimer’s disease: neuroprotective mechanisms and translational challenges
Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have…
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Artikel Jurnal
Proteostasis breakdown and aggregate diversity in aging and neurodegenerative disease
Protein aggregation and proteostasis decline are central features of aging and neurodegenerative disease, arising from progressive impairment of protein quality-control systems and transitions into aggregation-prone states. During aging, diverse proteins, including metabolic and…
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Artikel Jurnal
Spatiotemporal gait parameters during turning differ in Parkinson’s disease patients with and without freezing of gait
IntroductionTurning is a complex locomotor task that can accentuate gait impairments and precipitate freezing of gait (FOG) in Parkinson’s disease (PD). However, gait-derived spatiotemporal parameters during inter-episodic turning remain incompletely characterized. We compared turning-related gait…
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Artikel Jurnal
Network hierarchy in Alzheimer’s and Lewy body spectrum disorders: functional gradients, cognitive phenotypes, and translational gaps
Dementia syndromes alter cortical hierarchy in addition to individual brain regions. Functional connectivity gradients offer a continuous, low-dimensional framework for examining these hierarchy-level changes. This focused structured narrative review combines a transparent evidence audit with a…
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Artikel Jurnal
Effects of different interventions based on virtual reality on cognitive and motor function in elderly people with mild cognitive impairment or dementia: a systematic review and network meta-analysis
Virtual reality (VR)-based interventions are recognized as promising non-pharmacological therapies for enhancing cognitive and motor function in elderly patients with cognitive impairment. However, the comparative effectiveness of different VR-based interventions remains to be established. To…
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Artikel Jurnal
Triglyceride-glucose index is associated with cerebral small vessel disease-related motor impairment in Parkinson’s disease: a mediation analysis
BackgroundCerebral small vessel disease (CSVD) may worsen motor and cognitive impairment in Parkinson’s disease (PD), yet whether peripheral metabolic inflammation mediates this link remains unclear. The triglyceride-glucose (TyG) index, a surrogate for insulin resistance, has been associated with…
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Artikel Jurnal
The delta-opioid receptor: a therapeutic target for Alzheimer's disease
Alzheimer's disease (AD) presents a complex pathogenesis involving amyloid-β (Aβ) plaques, tau tangles, and neuroinflammation. Recent evidence highlights δ-opioid receptor (DOR) as a unique and promising therapeutic target for AD. This review summarizes current knowledge on DOR's multifaceted…
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Artikel Jurnal
Dual-task gait and gait-cognition coupling in patients with Parkinson’s disease versus healthy older adults: moderation by cognitive status
BackgroundGait impairment and cognitive decline frequently co-occur in Parkinson’s disease (PD), yet how cognitive status modulates dual-task gait-cognition relationships remains poorly characterized.ObjectiveTo compare spatiotemporal gait parameters and dual-task costs (DTCs) between drug-naïve PD…
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Artikel Jurnal
Semantic control across Alzheimer’s disease phenotypes: cognitive mechanisms and neural correlates
IntroductionSemantic cognition, our ability to understand meaning, relies on two distinct but interacting systems: one involved in knowledge representation and another in control processes. This control system is thought to comprise at least two mechanisms: controlled retrieval, which facilitates…
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Artikel Jurnal
Stage-dependent clinical burden in hospitalized Parkinson’s disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis
BackgroundOrthostatic hypotension (OH) is common in Parkinson’s disease (PD), but what is known of its clinical associations comes from ambulatory or population-based cohorts assessed under protocolised or tilt-table conditions. The patients whom a routine bedside screen identifies on a general…
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Artikel Jurnal
Impact of ultrasound-guided nerve block on postoperative delirium in elderly patients undergoing diabetic foot surgery: a propensity score-matched retrospective study
BackgroundPostoperative delirium (POD) is a common and serious complication in elderly patients undergoing diabetic foot surgery, often linked to excessive opioid use and systemic neuroinflammation. This study aimed to evaluate whether ultrasound-guided nerve block (NB) reduces the incidence of POD…
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Artikel Jurnal
Non-invasive brain stimulation on functional capacity in prefrail older adults: a protocol for a randomised clinical trial
IntroductionTherapeutic physical exercise (TPE) is considered the cornerstone intervention to prevent or reverse frailty; however, prefrail individuals often face challenges achieving the exercise intensity required to induce multisystem adaptations. Non-invasive neuromodulation…
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Artikel Jurnal
Joint effects of leukocyte-albumin ratio and hypertension are associated with multidimensional cognitive decline and Alzheimer’s disease risk in older adults: evidence from NHANES and a clinical AD validation cohort
BackgroundAlzheimer’s disease (AD) pathogenesis involves complex interactions between neuroinflammation and vascular dysfunction. While leukocyte-albumin ratio (LAR) and hypertension are independently linked to cognitive decline, their joint associations with multidimensional cognitive impairment…
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Artikel Jurnal
MTHFR C677T and A1298C polymorphisms in dementia susceptibility: evidence from a meta-analytic investigation with disease-specific and ethnicity-stratified analyses
BackgroundAlzheimer’s disease (AD) and vascular dementia (VaD) have become significant global health challenges. Recent research evidence indicates a close comorbidity between AD and cerebral small vessel disease. The C677T (rs1801133, also known as c.665C > T) and A1298C (rs1801131) polymorphisms…
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Artikel Jurnal
Cortical and subcortical morphological alterations in de novo GBA-related Parkinson’s disease
BackgroundThis study aimed to investigate cortical and subcortical changes in GBA-related Parkinson’s disease (GBA-PD) patients and evaluate the ability of these structural changes to identify patients with GBA-PD.MethodsT1-weighted magnetic resonance imaging images were obtained for 86…
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