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Artikel Jurnal
Machine learning-based radiomics modeling of combined subcortical nuclei from quantitative susceptibility mapping for Parkinson's disease diagnosis
BackgroundQuantitative susceptibility mapping (QSM) enables non-invasive assessment of brain iron deposition in Parkinson's disease (PD), yet existing radiomics studies have predominantly focused on single subcortical nuclei, without systematically evaluating whether combining multiple regions…
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Artikel Jurnal
Plasma multi-miRNA models classify Alzheimer’s, Parkinson’s, and Lewy body dementia
IntroductionDifferentiating Alzheimer’s disease (AD) from both Parkinson’s disease (PD) and Lewy body dementia (DLB) is difficult due to their clinical similarities. Plasma biomarkers offer an alternative to neuroimaging and cerebrospinal fluid analysis; however, there are limitations with respect…
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Artikel Jurnal
Trajectory-based identification of cognitive-performance phenotypes across adulthood from psychophysiological testing
BackgroundMultidimensional psychophysiological batteries reveal substantial inter-individual variation in processing speed, accuracy, memory, executive control, and visuospatial performance. Because the present sample is predominantly young to middle-aged, the analysis is framed as adult…
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Change detection in audio-visual space: neural evidence for age effects
IntroductionThe ability to perceive spatial changes is crucial for everyday life. However, the effects of age on multisensory integration in spatial change detection are still less researched. Here, we investigated whether audio-visual stimulation enhances spatial change detection compared to…
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Integrating computational modeling, neuroimaging, and neuromodulation to decompose perceptual decision-making in healthy aging: a review of methods, findings, and gaps
Perceptual decision-making (PDM) — the transformation of sensory input into behavioral choice — declines with healthy aging, leading to slower responses, altered accuracy, and negative impacts on quality of life. Recent advances in model-based cognitive neuroscience, particularly drift-diffusion…
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Multimodal integration of serum DAPK1 and gastric myoelectrical activity reveals stage-specific correlates in Parkinson’s disease
ObjectiveIntegrated biomarkers for cross-sectional multidimensional assessment of Parkinson’s disease (PD) remain limited. This study examined associations between serum DAPK1, a systemic molecular marker, and peripheral gastric myoelectrical activity assessed by electrogastrography (EGG) in…
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Artikel Jurnal
Protein C activity may reflect endogenous anticoagulant balance and is associated with stroke severity and functional outcomes in acute ischemic stroke
BackgroundAging is associated with a shift toward a prothrombotic state, partly driven by alterations in endogenous anticoagulant pathways. Protein C is a key component of this pathway, but the clinical relevance of variation in protein C activity for ischemic stroke has not been fully established…
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Artikel Jurnal
When mild impairment is not safe: mini-mental state examination scores of ≤21 are associated with emergency response failure
IntroductionUnrecognized emergency-response deficits contribute to preventable harm and loss of independence in older adults with cognitive decline. Although the Mini-Mental State Examination (MMSE) is widely used to assess global cognition, clinicians often use MMSE scores to inform judgments…
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Mitochondrial transplantation for delirium superimposed on dementia: from pathogenic mechanisms to clinical translation challenges
Delirium Superimposed on Dementia (DSD) is a common neuropsychiatric disorder in hospitalized elderly populations with poor prognosis, which can accelerate cognitive decline and increase mortality. Despite its clinical significance, there is a lack of effective therapeutic methods in clinical…
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Acceptability and feasibility of an adapted Portuguese folk dance–based therapy in older adults with moderate-to-severe dementia and balance impairment
IntroductionPopulation ageing has increased the prevalence of dementia, often accompanied by mobility impairments. It is essential to develop effective interventions and promote adherence among people with dementia. Culturally meaningful activities may enhance motivation, engagement, and…
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Artikel Jurnal
Layered classification in Parkinson’s disease: a content analysis of clinical, prodromal, and biological criteria evolution
BackgroundParkinson’s disease (PD) is no longer described through a single diagnostic vocabulary. Clinical criteria, prodromal probability models, and biological research classifications now operate in parallel after the 2024 NSD-ISS and SynNeurGe proposals.ObjectiveTo clarify how major PD criteria…
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Artikel Jurnal
Cell-type-dependent decline of IGF1 and IGF1R in the prefrontal cortex contributes to age-related behavioral changes
Insulin-like growth factor 1 (IGF1) signaling plays a critical role in brain function and declines significantly with aging. However, how these changes occur across different brain regions and cell types, and how they contribute to behavioral dysfunction, remains poorly understood. The prefrontal…
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Reduced BOLD-CSF coupling as a potential functional imaging correlate of semantic fluency decline in MRI-negative temporal lobe epilepsy
IntroductionThis study investigated neurovascular–cerebrospinal fluid dynamic interactions using blood-oxygen-level-dependent–cerebrospinal fluid (BOLD-CSF) coupling metrics and examined their associations with cognitive impairment in patients with MRI-negative unilateral temporal lobe epilepsy…
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Silent neurovestibular frailty: a conceptual model integrating vestibular dysfunction, dual-task mobility and cognitive load as candidate contributors to falls, delirium and functional decline in older adults
Falls, delirium and functional decline are commonly treated as distinct geriatric outcomes despite sharing vulnerabilities in sensory integration, gait regulation, attention and physiological reserve. We propose silent neurovestibular frailty as a conceptual model describing a latent ageing…
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Artikel Jurnal
Association between Alzheimer’s disease-related genes and neurodegenerative blood-based biomarkers in Indian adults
BackgroundAlzheimer’s disease (AD) and related dementias are a growing health and economic burden in India. Blood levels of amyloid beta (Ab), tau, and other proteins marking neuronal injury are biomarkers of AD risk and are potentially important for AD prevention.MethodsIn 2,224 participants from…
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Artikel Jurnal
Altered activation patterns of sensorimotor cortex during level walking and stair climbing in patients with knee osteoarthritis: a cross-sectional study
BackgroundKnee osteoarthritis (KOA) is characterized not only by peripheral joint pathology but also by mechanisms related to central sensitization. Previous studies have reported reduced activation of sensorimotor cortex during isolated joint movements in patients with KOA. However, cortical…
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Artikel Jurnal
Tai Chi for improving motor symptoms in Parkinson’s disease patients: a systematic review of mechanisms
BackgroundIn recent years, Tai Chi (TC) training has played an increasingly important role in the management of motor disorders in Parkinson’s disease (PD) patients. A thorough understanding of the therapeutic mechanisms of TC is crucial for optimizing its clinical efficacy. The long-term practice…
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Using QSM to investigate the iron deposition patterns in deep gray matter nuclei during the aging process in healthy populations
ObjectiveWe utilized 3.0T quantitative susceptibility mapping (QSM) technology to simultaneously investigate (a) the relationship between susceptibility values of deep gray matter (DGM) nuclei and age in healthy populations throughout the aging process, and (b) the correlation of iron deposition…
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