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Artikel Jurnal
Trajectories of chronic disease burden, depressive symptoms, and functional limitations related to falls in middle-aged and older adults: a matched longitudinal study
BackgroundFalls are often treated as isolated events, but the physiological, psychological, and functional trajectories surrounding a first fall remain poorly understood. We examined chronic disease burden, depressive symptoms, and activities of daily living (ADL) limitations before and after first…
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Artikel Jurnal
Imaging the therapeutic effects of cerebral endothelial cell derived exosome treatment of a preclinical model of Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is characterized by the excessive accumulation of select proteins in the brain, associated with altered vascular function, glymphatic transport, cerebrospinal fluid (CSF) dynamics, and cerebral microstructure. Exosomes derived from cerebral endothelial cells…
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Artikel Jurnal
Herpes simplex virus infection and Alzheimer’s disease
Over 95% of Alzheimer’s disease (AD) is caused by a complex mixture of genetic and environmental factors. This is called sporadic AD or late-onset AD, and much of its pathological mechanisms remain unclear. There is growing evidence indicating that the viral infection, such as herpes simplex virus…
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Artikel Jurnal
Choroid plexus enlargement is negatively associated with cognitive performance in a DTI-ALPS–dependent manner
BackgroundDisturbances in brain fluid homeostasis are increasingly implicated in neurodegeneration. Imaging measures of structural alterations of the choroid plexus (CP) and impaired glymphatic transport have each been associated with cognitive decline, yet their potential interaction in humans…
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Artikel Jurnal
Translating blood-based biomarkers into Alzheimer’s disease clinical practice: screening, diagnosis, and longitudinal monitoring
Blood-based biomarkers (BBMs) are increasingly being integrated into Alzheimer’s disease (AD) clinical pathways by providing scalable tools to track amyloid, tau, neurodegeneration, and inflammation dimensions of the ATN-I framework. As biological characterization and biomarker-informed assessment…
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Artikel Jurnal
Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study
Background and purposeAccurately defining cognitive function trajectories in elderly ischemic stroke patients is crucial for identifying high-risk groups for cognitive decline, enabling timely personalized interventions to improve long-term outcomes and reduce familial and societal burdens…
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Artikel Jurnal
Effects of the multidomain non-pharmacological interventions on anxiety symptoms and depressive symptoms in older adults with suspected cognitive impairment: a propensity score matching and difference-in-differences analysis
BackgroundMental health problems among older adults with cognitive impairment have attracted increasing attention. Although non-pharmacological interventions (NPIs) are considered safe and feasible, evidence regarding their effects on older adults with suspected cognitive impairment in Southwest…
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Artikel Jurnal
Striatal small RNA remodeling in MPTP-induced Parkinson’s disease highlights coordinated downregulation of mitochondrial tsRNAs
Parkinson’s disease (PD) is characterized by progressive nigrostriatal degeneration, yet the contribution of modification-rich small RNAs to PD pathology remains unclear. Here, we used PANDORA-seq to profile the striatal small RNA landscape in a subacute MPTP-induced mouse model of PD. MPTP-treated…
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Artikel Jurnal
Target-level convergence of directional prefrontal connectivity across Alzheimer’s disease stages: an fNIRS study
BackgroundAlzheimer’s disease (AD) is increasingly recognized as involving network-level dysfunction rather than isolated regional impairment. Although functional and effective connectivity have been studied in dementia, the reorganization of directional information flow within prefrontal networks…
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Artikel Jurnal
Epicenter mapping of cortical morphological dedifferentiation in type 2 diabetes mellitus using morphometric inverse divergence
BackgroundType 2 diabetes mellitus (T2DM) is associated with widespread cortical alterations and cognitive decline. However, the macroscopic organizational principles of T2DM-associated cortical degradation remain poorly understood. This study investigated whether T2DM-related cortical…
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Artikel Jurnal
Cerebrospinal fluid and plasma biomarkers in idiopathic normal pressure hydrocephalus: comparison with Alzheimer's and Parkinson's diseases
BackgroundIdiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological disorder whose diagnosis is complicated by clinical overlap with neurodegenerative diseases. Fluid biomarkers may provide insight into disease mechanisms and support differential diagnosis.MethodsWe…
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Artikel Jurnal
A transdiagnostic approach to non-motor symptoms in Parkinson’s disease: exploring internalizing, bipolar spectrum, and impulsive compulsive behavior profiles via cluster analysis
BackgroundParkinson’s disease (PD) is associated with diverse non-motor symptoms (NMS), including depression, anxiety, anhedonia, bipolar-spectrum features, and impulsive-compulsive behaviors (ICBs), which substantially impair quality of life. Although these domains may share dopaminergic and…
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Artikel Jurnal
Association of the hsCRP- triglyceride-glucose index (CTI) with early infarct growth rate in acute ischemic stroke due to large artery occlusion
BackgroundRapid infarct growth in acute ischemic stroke (AIS) due to large artery occlusion (LAO) is associated with poor clinical outcomes despite successful recanalization. The hypersensitive C-reactive protein (hsCRP)-triglyceride-glucose (TyG) index (CTI), a novel biomarker integrating insulin…
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Artikel Jurnal
DTI-ALPS index and cognitive impairment in cerebral small vessel disease: a systematic review and meta-analysis
ObjectiveThe diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is a non-invasive diffusion tensor imaging-based metric proposed to reflect glymphatic processes. This meta-analysis aimed to evaluate the association of the DTI-ALPS index with cerebral small vessel disease…
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Artikel Jurnal
Two serial MoCA assessments may support biomarker-sparing triage between Parkinson’s disease/Lewy body dementia and frontotemporal dementia: a progressive inclusion analysis of 1,129 participants
Reliable differentiation of Parkinson’s disease/Lewy body dementia (PD/LBD) from frontotemporal dementia (FTD) affects treatment strategy and clinical trial eligibility, yet confirmatory biomarker testing remains costly and unevenly available. Whether routine cognitive trajectories can support…
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Artikel Jurnal
The association between hearing loss in adults and cognitive outcomes: an umbrella review and meta-analysis
PurposeHearing loss (HL) has been increasingly recognized as a potential risk factor for cognitive decline and dementia. However, findings from existing meta-analyses remain heterogeneous. This umbrella review aimed to comprehensively synthesize current meta-analytic evidence on the association…
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Artikel Jurnal
Modulation of fronto-parietal and autonomic activity underpins preserved working memory in middle-aged adults
BackgroundCognitive aging is a heterogeneous process, often diverging from chronological age. However, it remains unclear when early signs of cognitive decline emerge and which neurophysiological markers distinguish age-related cognitive alteration from preserved performances. This study aimed to…
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