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Artikel Jurnal
Query-based multimodal interaction and adaptive gated fusion for Alzheimer's disease detection
Early detection of Alzheimer's disease is crucial for delaying disease progression and improving patient outcomes. Speech has emerged as a promising biomarker for Alzheimer's disease detection because it is convenient, non-invasive, and low-cost. However, existing studies often rely on a single…
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Artikel Jurnal
Astragaloside IV attenuates hypoxia-reoxygenation-induced endothelial senescence and vascular inflammation by modulating the NOTCH1/VCAM-1 axis
ObjectiveAlzheimer's disease (AD) progression involves cerebral microvascular endothelial cell senescence induced by brain hypoperfusion, which contributes to blood-brain barrier (BBB) dysfunction. While Notch1 signaling is known to exacerbate endothelial senescence and neuroinflammation via…
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Transcriptomic signatures as biomarkers for the progression of mild cognitive impairment
ObjectiveMild cognitive impairment (MCI) is acknowledged as an early and potentially modifiable stage of Alzheimer’s disease (AD). Despite this, there is a paucity of reliable molecular markers for predicting MCI progression. This study utilizes next-generation sequencing to elucidate alterations…
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Restoring anticipatory control through cognitive–motor dual-task training improves emotional and executive function in frail older adults
BackgroundAging-related frailty is increasingly recognized as a multidimensional condition involving impairments in cognitive, emotional, and motor domains. Traditional interventions often fail to capture the complexity of real-world functioning, highlighting the need for more ecologically valid…
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The molecular mechanisms of Guizhi Fuling Pills in ameliorating Alzheimer’s disease-like cognitive impairment: insights from transcriptomics, metabolomics, and gut microbiome
BackgroundAlzheimer’s disease (AD)-like cognitive impairment, as a major type of cognitive disorder, has witnessed a sharp rise in prevalence. Therefore, there is an urgent need to develop effective therapeutic intervention measures. Guizhi Fuling Pills (GFP), a classical Traditional Chinese…
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Artikel Jurnal
Sex- and age-dependent associations between waist-to-hip ratio and cognitive impairment: a cross-sectional study of rural adults aged 40 years and older in northwestern China
BackgroundObesity is a modifiable risk factor for cognitive impairment; however, body mass index fails to capture fat distribution. Waist-to-hip ratio (WHR), reflecting central adiposity, may better characterize obesity-related differences in cognitive impairment. Nevertheless, whether the…
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Potential effects of β-hydroxy-β-methylbutyrate and exercise on brain aging and age-related disorders: implications for immunometabolic regulation and muscle–brain–immune crosstalk
β-Hydroxy-β-methylbutyrate (HMB), a bioactive leucine metabolite, has emerged as a potentially valuable nutritional compound with effects extending beyond skeletal muscle metabolism toward systemic immunometabolic regulation. This review summarizes evidence from 24 experimental and clinical studies…
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A male rat model integrating hypertension, chronic cerebral hypoperfusion, and aging recapitulates multimodal cerebral small vessel disease phenotypes
BackgroundCerebral small vessel disease (CSVD) usually develops under the combined influence of vascular risk factors, chronic perfusion insufficiency, and age-related brain vulnerability; however, animal models driven by a single insult do not fully reproduce this multifactorial clinical…
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Exercise alone or combined with functional foods in aging and age-related diseases: targeting DNA damage, repair pathways, and genome integrity
Aging is fundamentally associated with the gradual accumulation of DNA damage, which is instrumental in the initiation and advancement of age-associated pathologies, including neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease. Recent studies indicate that lifestyle…
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Effects of Tai Chi on functional performance and fall-related psychological outcomes in Parkinson’s disease: a systematic review and meta-analysis
ObjectiveTo systematically evaluate the effects of Tai Chi on objective motor performance and subjective fall-related psychological outcomes in patients with Parkinson’s disease (PD), and to examine whether intervention characteristics influence the magnitude of therapeutic…
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Artikel Jurnal
Plasma α-synuclein and QSM-derived susceptibility in Parkinson’s disease: associations with clinical features
BackgroundThe pathological interplay between α-synuclein aggregation and iron dysregulation is central to the neurodegenerative process in Parkinson’s disease (PD). Quantitative susceptibility mapping (QSM) allows in vivo assessment of regional brain iron burden, and blood assays enable measurement…
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Multimodal characterization of cortical hyperexcitability as a driver of cognitive decline in neurocognitive disorders: study protocol for the LENDÜLET Neurocognitive Research Project
IntroductionCognitive impairment is a major source of disability in neurodegenerative conditions, and it is also highly prevalent in autism spectrum disorder and attention-deficit/hyperactivity disorder. Across these conditions, subclinical epileptiform activity and resting-state functional…
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P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure
Alzheimer's disease (AD) is characterized not only by amyloid-β and tau pathology but also by progressive failure of multicellular homeostasis. The P2X7 receptor (P2X7R), a low-affinity ATP-gated ion channel preferentially activated in extracellular ATP-rich pathological microenvironments, is well…
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Acute total sleep deprivation transiently increases plasma total tau but not plasma P-tau181 in healthy adults
BackgroundSleep deprivation is a modifiable risk factor for Alzheimer’s disease (AD). Plasma amyloid-β (Aβ) and phosphorylated tau (P-tau) are closely related to cerebral AD pathology and serve as peripheral biomarkers. Our previous work showed that acute sleep deprivation elevated plasma Aβ40 in…
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Artikel Jurnal
Role of STX1A in Parkinson’s disease: evidence, mechanistic hypotheses, and translational perspectives
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by degeneration of substantia nigra dopaminergic neurons, α-synuclein pathology, and widespread synaptic dysfunction. Syntaxin-1A (STX1A), a presynaptic Qa-SNARE protein, is essential for synaptic vesicle fusion and…
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Direct toll-like receptor 4 inhibition in Alzheimer’s disease models: a focused scoping review of inflammatory, amyloid-handling, and functional outcomes
ObjectiveThis focused scoping review evaluated whether direct toll-like receptor 4 (TLR4) inhibition, antagonism, or genetic suppression in Alzheimer’s disease (AD)-related models was associated with concordant inflammatory, amyloid-β (Aβ)-handling, and functional outcomes.MethodsOriginal AD- or…
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From pathology to network failure: a Question–Model–Outcome framework for interpreting animal models of AD-related and dementia-relevant mechanisms
Animal studies remain indispensable for research on Alzheimer's disease (AD), vascular cognitive impairment, and other dementia-relevant mechanisms. Their value, however, is not that they reproduce human late-life dementia in miniature. A mouse line, vascular manipulation, or mixed-pathology…
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Sensory impairment and cognitive-state transitions in middle-aged and older adults: a multistate Markov analysis of the health and retirement study
BackgroundSensory impairment has been associated with cognitive decline and dementia. However, endpoint-based longitudinal analyses often cannot determine whether sensory impairment is related to early cognitive deterioration, reduced cognitive recovery, dementia progression, or mortality-related…
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Artikel Jurnal
Age-related cortical mechanisms underlying postural control: a systematic review
IntroductionDespite growing interest in age-related cortical mechanisms of postural control, heterogeneity across studies has limited the synthesis of existing evidence. This systematic review aimed to (1) characterize age-related alterations in cortical activity during standing balance tasks with…
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Artikel Jurnal
Explainable machine learning for Alzheimer's disease characterization using small-sample EEG data
Alzheimer's disease (AD) is associated with progressive cognitive decline and altered brain functional activity, yet objective and interpretable electrophysiological indicators remain insufficiently established. Resting-state electroencephalography (EEG) offers a low-cost and clinically accessible…
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