8,223 results
Showing 381–400 · 0.32 seconds · RSS
-
Journal Article
CRISPR-based functional genomic screening in neurodegeneration: mechanistic insights into AD, PD, and ALS
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by pronounced clinical and molecular heterogeneity, as well as highly interconnected pathogenic pathways. This biological complexity has long hindered…
-
Journal Article
Seed amplification of released alpha-synuclein strains reveals genotype-specific differences in Parkinson’s disease neurons
Parkinson’s disease is one of a group of diseases collectively termed α-synucleinopathies, all of which are characterized by abnormal accumulation of toxic α-synuclein (α-syn) assemblies which are thought to follow a prion-like propagation model and drive neuronal death. Both intrinsic strain…
-
Journal Article
Hippocampal subfield diffusion abnormalities in Parkinson’s disease with mild cognitive impairment: a volumetric and diffusion MRI study
ObjectiveTo investigate whether patients with Parkinson’s disease with mild cognitive impairment exhibit hippocampal subfield-specific macrostructural and microstructural alterations and to determine whether these imaging abnormalities are associated with global cognitive performance.MethodsThis…
-
Journal Article
Integrating Baduanjin exercise into Parkinson’s rehabilitation: a randomized controlled trial
ObjectiveTo evaluate whether adding Baduanjin exercise to conventional physiotherapy improves balance, functional mobility, walking capacity, and motor signs compared with conventional physiotherapy alone in nursing-home residents with Parkinson’s disease.MethodsThis assessor-blinded, two-group…
-
Journal Article
Dissecting neuronal circuit function and dysfunction in Alzheimer’s disease mouse models: from conventional calcium imaging analysis to machine learning-based approaches
In vivo calcium imaging is a powerful technique for the monitoring activity of large neuronal populations in the intact brain. Two-photon microscopy provides subcellular resolution in head-fixed animals, and miniaturized fluorescence microscopy (miniscope) enables recordings of neuronal network…
-
Journal Article
MAFF as a potential novel protective factor against Parkinson’s disease: evidence from Mendelian randomization and single-cell RNA sequencing
BackgroundParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Although MAFF may be involved in PD, the mechanisms underlying this association remain unclear. This study aimed to investigate the potential mechanisms of MAFF in PD and identify novel therapeutic…
-
Journal Article
Comprehensive analysis of circRNA-miRNA-mRNA networks to reveal potential cell death, inflammation and oxidative stress-related targets for postoperative cognitive dysfunction
BackgroundPostoperative cognitive dysfunction (POCD) is a common neurological complication involving the hippocampus, a brain region critical for learning and memory. Circular RNA (circRNA) plays an important role in regulating gene expression. Our objective is to predict and verify a…
-
Journal Article
Sleep-dependent alterations in anterior cingulate cortex excitation–inhibition balance link alterations in BOLD-CSF coupling to cognitive performance in obstructive sleep apnea
ObjectiveThe roles of cortical glymphatic dysfunction and excitation-inhibition imbalance in cognitive impairment associated with obstructive sleep apnea (OSA) require further study. This study aimed to investigate sleep-related glymphatic function and neurotransmitter changes in OSA and their…
-
Journal Article
Gait characteristics in older adults using the ProtoKinetics Zeno walkway: the atherosclerosis risk in communities (ARIC) study
BackgroundGait speed is an important indicator of functional status and health outcomes in older adults. Electronic gait mats are common in research, but stopwatches are more feasible in clinical practice. This study compared agreement between single task (ST) gait speed measured by stopwatch and…
-
Journal Article
Interpretable machine learning model based on multimodal MRI radiomics for Alzheimer's disease diagnosis
ObjectiveAlzheimer's disease (AD), the most common neurodegenerative disorder, is a leading cause of cognitive impairment and dementia in older adults. This study aimed to develop an interpretable machine learning model using multimodal MRI radiomics for the diagnosis of Alzheimer's…
-
Journal Article
Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association
BackgroundThere has been some evidence that neuroinflammation is involved in Parkinson's disease (PD) and in psychiatric disorders.ObjectiveTo explore the effects of IL-1β rs16944 on PD patients' neuropsychiatric symptoms.MethodsTwo hundred and eighty-one consecutive PD patients underwent a…
-
Journal Article
A validated workflow for paired total and small RNA sequencing from low-input submandibular gland biopsy specimens in de novo Parkinson’s disease patients
Parkinson’s disease (PD) is characterized by progressive α-synuclein aggregation, yet the molecular mechanisms underlying this process remain incompletely understood. Transcriptomic analyses may provide important insights into the RNA-mediated regulation of PD pathogenesis, but studies of affected…
-
Journal Article
Short-term environmental enrichment modulates brain region-specific redox responses in adolescent female mice
BackgroundEnvironmental enrichment (EE) is a non-pharmacological intervention known to enhance neuroplasticity and resilience. However, studies of EE on brain redox balance have focused predominantly on males and single regions, leaving the developing female brain and region-specific responses…
-
Journal Article
Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions
Age-related hearing loss (ARHL) is the most common sensory disorder in older adults. Current hearing interventions, including hearing aids and cochlear implants, face limitations in accessibility and adherence. Therefore, efforts have been devoted to elucidating the molecular mechanisms underlying…
-
Journal Article
Age-related variation in the association between intraoperative dynamic cerebral autoregulation impairment proportion and postoperative neutrophil-to-lymphocyte ratio: an exploratory observational study
BackgroundDynamic cerebral autoregulation (dCA) impairment during surgery has been associated with adverse neurologic outcomes. Whether the burden of impaired dCA is related to the postoperative peripheral inflammatory response, and whether this association varies with age, remains…
-
Journal Article
The gut microbiota dysbiosis in ischemic stroke: a systematic review and meta-analysis of microbial diversity and taxonomic alterations
ObjectiveClinical and epidemiological evidence suggests a link between gut microbiota and ischemic stroke severity as well as outcomes, yet inconsistent findings and unclear mechanisms underscore the need for a systematic synthesis.MethodsWe systematically reviewed and meta-analyzed observational…
-
Journal Article
Long non-coding RNAs in glial cells: key drivers of neuroinflammation in cognitive disorders
Neurodegenerative diseases (NDs) are characterized by the progressive deterioration of cognitive and motor functions. In this context, glial cell-mediated neuroinflammation is recognized as a key driver of disease progression. Long non-coding RNAs (lncRNAs) have emerged as key epigenetic regulators…
Showing at most 50 pages. Narrow your search with filters for more specific results.