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Artikel Jurnal
Knowledge structure and frontier trends of exercise interventions for Parkinson’s disease: a bibliometric and visualized analysis
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder with motor and non-motor manifestations. Exercise is increasingly integrated into the management of people with PD, yet the literature spans diverse intervention modalities, outcome domains, and mechanism-related…
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Artikel Jurnal
Sex hormones in the nucleus incertus: a novel perspective on sex/gender differences in memory and mood dysfunction in Alzheimer’s disease
About 60% of the individuals living with Alzheimer’s disease (AD) in the United States are women. Increasing evidence points to a role for sex hormones, especially estrogen, in making women more vulnerable to AD than men. Several brainstem signaling pathways, as well as multiple neuropeptide…
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Artikel Jurnal
Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders
Oxidative stress, iron dyshomeostasis, and chronic neuroinflammation are the principal mechanisms involved in the progression of central nervous system (CNS) disorders, which are a significant source of death and chronic disability worldwide. This review focuses on understanding the mechanistic…
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Artikel Jurnal
Joint network analysis of non-motor symptoms and quality of life in patients with Parkinson’s disease
BackgroundNon-motor symptoms (NMS) are highly prevalent in Parkinson’s disease (PD) and are major determinants of declining quality of life (QoL), yet traditional statistical approaches are insufficient to capture the complex interactions between NMS and QoL. Network analysis offers a promising…
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Artikel Jurnal
The excitatory neurotransmitter glutamate and its receptors: the culprits behind neuropathic pain?
Human understanding of the nature of pain has undergone a profound shift from mechanical reductionism to a multidimensional, integrative approach. Among the many types of chronic pain, neuropathic pain (NP) has long been a key focus of research in the fields of neurobiology and pain medicine, owing…
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Artikel Jurnal
Inflammation and delirium in critically Ill patients: a review
The high prevalence and adverse impact of delirium in critically ill patients necessitate a deeper understanding of its mechanisms. This review explores the pivotal interplay between systemic inflammation and delirium, examining how insults like age, pain and surgery orchestrate neuroinflammation…
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Artikel Jurnal
Short-term ambient temperature increases are associated with higher mortality in amyotrophic lateral sclerosis: a case-crossover study of weather conditions
IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with vastly differing survival times. The influence of environmental exposures such as weather conditions on mortality among people living with ALS remain poorly defined. The aim of this study was to evaluate the…
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Artikel Jurnal
Region-specific brain metabolite reference estimates and exploratory age-related changes in cognitively intact older adults: a preliminary deep-learning 1H-MRS study
IntroductionNormative brain metabolite references are essential for evaluating metabolic change in rehabilitation patients with stroke, traumatic brain injury, or cognitive decline. We provide preliminary, cohort-specific reference estimates in cognitively healthy older adults using proton magnetic…
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Artikel Jurnal
Joint trajectories of obesity and depressive symptoms and risk of incident glaucoma: a 16-year prospective cohort study from the Health and Retirement Study
BackgroundObesity and depression frequently co-occur in older adults and share pathways potentially relevant to glaucoma, yet their dynamic co-evolution and joint contribution to glaucoma risk remain poorly characterized.ObjectivesThis study aimed to identify joint longitudinal trajectories of body…
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The application of traditional machine learning and deep learning with EEG for mild cognitive impairment: a bibliometric analysis
ObjectiveThis study uses bibliometric methods to analyze the status of electroencephalography (EEG) and machine learning applications in mild cognitive impairment (MCI) research.MethodsRelevant literature was searched in the four major English databases (Web of Science, PubMed, IEEE Xplore, and…
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Artikel Jurnal
Resting-state EEG microstate dynamics indicate altered brain network temporal organization in age-related hearing loss
ObjectiveAge-related hearing loss (ARHL) is increasingly recognized as a condition that involves changes in the central nervous system beyond the auditory pathway, with growing evidence showing altered large-scale brain network connectivity. However, how ARHL reshapes the temporal organization of…
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Artikel Jurnal
A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease
Neuromodulation techniques in the gamma frequency range, such as chronic 40 Hz sensory stimulation, have gained attention for their potential to impact and preserve cognitive function in the context of neurodegenerative disorders such as Alzheimer’s disease (AD). This hypothesis and theory article…
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Artikel Jurnal
DNA hydroxymethylation-mediated epigenetic modifications in alcohol use disorder
Alcohol use disorder (AUD) is a chronic neuropsychiatric condition that causes an increased risk of dementia and deaths worldwide. Evidence indicates that alcohol misuse can induce changes in genetic factors. Alcohol-induced DNA epigenetic modification alters brain function and contributes to AUD…
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Artikel Jurnal
Pericarotid fat density: a novel predictor of cognitive and functional outcomes in cerebral small vessel disease
BackgroundPericarotid fat density (PFD) obtained by computed tomography angiography (CTA) could serve as a surrogate biomarker reflecting local inflammation. The study aimed to quantitatively estimate the impact of PFD on cognitive and functional outcomes in patients with cerebral small vessel…
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Artikel Jurnal
Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats
Age is the primary risk factor for neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease, which are characterized by profound loss of midbrain dopaminergic neurons and basal forebrain cholinergic neurons, respectively. In addition, loss of these neurons can occur even in…
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Artikel Jurnal
Risk factors for postoperative cognitive dysfunction in geriatric trauma: a dual-pathway perspective
Postoperative cognitive dysfunction (POCD) is common in geriatric trauma patients and involves complex underlying mechanisms. Most existing studies have focused on isolated risk factors, with limited attention to how these factors interact. In this perspective article, we propose a dual-pathway…
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Artikel Jurnal
Sequential reaching in older adults: vibrotactile feedback improves preparation and movement control
IntroductionAge-related motor decline is particularly evident during complex movements that require sequencing and bimanual coordination. The one-target advantage (OTA), in which single-target movements are typically initiated faster than the first segment of a two-target sequence, provides a…
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Artikel Jurnal
Atrial fibrillation/atrial flutter and reduced volumes of the hippocampus, amygdala, and thalamus: evidence from a community-based MRI study
IntroductionAtrial fibrillation (AF) is associated with cognitive decline and dementia even in the absence of clinical stroke, potentially through mechanisms such as silent infarction, small-vessel disease, hypoperfusion, and systemic inflammation. However, most previous studies have focused on…
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Artikel Jurnal
Predominantly left-lateralized EEG–EMG associations following gamma–theta stimulation in older adults with mild cognitive impairment
IntroductionMild cognitive impairment (MCI) is frequently accompanied by impairments in postural control and trunk muscle function. Although gamma–theta rhythmic stimulation has been reported to modulate neural oscillatory activity, its influence on brain–muscle interactions in individuals with MCI…
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Artikel Jurnal
Adjunctive EGb 761 treatment in patients with Parkinson’s disease: a case series
BackgroundParkinson’s disease (PD) is the second most common neurodegenerative disease. It is based on a gradual decrease in the number of dopaminergic neurons in the midbrain. Since various pathological processes, including oxidative stress, neuroinflammation, and impaired neuroplasticity, are…
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