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Artikel Jurnal
Can smoking history, peripheral inflammation, and nutritional status discriminate Parkinson’s disease? Development and validation of a clinically accessible nomogram
BackgroundParkinson’s disease (PD) is a major public health challenge in China, with rising prevalence and limited early diagnostic tools. Systemic inflammation and nutritional status are increasingly recognized as key modulators of PD pathogenesis, but integrated predictive models remain…
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Artikel Jurnal
Sleep Apnoea and Memory (SAM): protocol for a prospective study of prevalence and symptoms of sleep apnoea in memory clinics
IntroductionSleep apnoea is common in older adults and a risk factor for cognitive decline and dementia but is rarely assessed in memory clinics. The Sleep Apnoea and Memory (SAM) study will assess the prevalence of sleep apnoea and identify optimal screening for sleep apnoea in memory…
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Artikel Jurnal
PredatorNet: a clinically trustworthy deep learning framework for multi-class Alzheimer's disease classification using MRI
MRI-based staging of Alzheimer's Disease (AD) requires not only high classification accuracy but also clinically reliable probability estimates, transparent evidence for decisions, and robustness to shifts in data distribution. We propose PredatorNet, a multi-class AD classification framework with…
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Artikel Jurnal
APOE ε4-associated hippocampal atrophy trajectories across the Alzheimer's disease continuum: a systematic review, meta-analysis, and longitudinal validation
BackgroundPredicting patient-specific neurodegenerative trajectories is essential for targeted interventions in Alzheimer's disease. Although the APOE-ε4 allele is the predominant genetic risk factor for hippocampal atrophy, whether its structural impact reflects a static developmental phenotype or…
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Artikel Jurnal
Imaging the neurohiv brain in animal models: past, present, and future—toward longitudinal, whole-brain aging phenotypes
Animal models are essential for defining mechanisms of HIV-associated brain injury in the antiretroviral therapy era, where neurocognitive impairment and brain aging have replaced opportunistic infections as dominant clinical concerns. Humanized mice, EcoHIV murine systems, and SIV or SHIV nonhuman…
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Artikel Jurnal
A multi-view graph neural network framework for Parkinson’s disease identification based on dynamic functional connectivity
Parkinson’s disease (PD) is a common neurodegenerative disorder, and accurate diagnosis is crucial for timely intervention. Dynamic functional connectivity (DFC) analysis of resting-state functional magnetic resonance imaging (rs-fMRI) can capture the time-varying characteristics of brain networks…
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Artikel Jurnal
Glymphatic dysfunction in Alzheimer's disease: a systematic review and meta-analysis of the DTI-ALPS index as an imaging biomarker
IntroductionAlthough the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is widely utilized as a proxy for glymphatic function in Alzheimer's Disease (AD) research, its association with core AD pathological biomarkers remains inconclusive due to inter-study…
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Artikel Jurnal
Novel proteomics and neuropathology of NOTCH2NLC-related neuronal intranuclear inclusion disease
BackgroundNucleotide repeat expansion disorders constitute a group of clinically and genetically heterogeneous diseases, pathologically characterized by the misfolding, aggregation, and accumulation of proteins. The expanded GGC repeats in the 5′ untranslated region (5’UTR) of the NOTCH2NLC gene…
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Artikel Jurnal
Chronic stress, cortisol dysregulation, and neurodegenerative vulnerability: mechanistic pathways linking HPA-axis dysfunction to Alzheimer’s disease risk
Chronic psychological stress is increasingly recognized as a silent risk factor of long-term brain vulnerability and a potential modifier of neurodegenerative disease trajectories. The persistent activation of the hypothalamic–pituitary–adrenal (HPA) axis and the consequent dysregulation of…
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Artikel Jurnal
Imaging biomarkers in neurodegenerative diseases: advances and challenges
Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), represent a major global health burden. Imaging biomarkers have emerged as important tools for improving the diagnosis…
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Artikel Jurnal
Baseline facial emotion recognition is associated with clinical decline across the Alzheimer’s disease spectrum: a multi-instrument longitudinal assessment study
BackgroundFacial emotion recognition (FER) is increasingly recognized as a functionally relevant domain in the Alzheimer’s disease (AD) spectrum, yet whether baseline FER is associated with subsequent clinical decline remains insufficiently established.MethodsWe studied 328 participants [subjective…
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Artikel Jurnal
Age-associated microglial heterogeneity includes emergence of mobile microglial states
Microglia maintain neuronal homeostasis through dynamic surveillance strategies that depend on their functional state. In the healthy brain, highly ramified microglia monitor neuronal integrity via motile processes and transient soma contacts. Aging is associated with reduced process motility and…
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Artikel Jurnal
Comparative effectiveness of non-pharmacological interventions for post-stroke upper limb motor dysfunction: a systematic review and network meta-analysis of randomized controlled trials
BackgroundPost-stroke upper limb motor dysfunction (PS-ULMD) is a common and disabling consequence of stroke. Although multiple non-pharmacological interventions are used to treat PS-ULMD, the optimal treatment remains unclear. Thus, this study aimed to identify effective non-pharmacological…
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Artikel Jurnal
Relationship between executive function and activities of daily living in Alzheimer’s disease: a study based on the stop-signal task
BackgroundEarly clinical manifestations of Alzheimer’s disease (AD) include an apparent decline in memory and executive function. Executive function is closely related to activities of daily living (ADL) and is important for maintaining an independent, high-quality lifestyle.ObjectiveThis study…
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Artikel Jurnal
Mild cognitive impairment risk related to multiple functional impairments in older adults in Taiwan
BackgroundMild cognitive impairment (MCI) is a critical transition stage toward dementia, making the identification of modifiable risk factors essential for early intervention. While individual conditions such as sensory loss, tooth loss, and psychological distress are independently linked to…
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Artikel Jurnal
JAK/STAT signaling pathway inhibitors in neurodegenerative diseases: current status and future perspectives
Neurodegenerative diseases (NDDs) are a major public health concern characterized by the progressive loss of neurons, ultimately leading to neuronal death and causing a sustained decline in brain function or physical motor abilities. Major examples include Alzheimer’s disease (AD) and Parkinson’s…
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Artikel Jurnal
Research waste of randomized controlled trials related to deep brain stimulation: a cross-sectional analysis
BackgroundResearch waste undermines the value of clinical trials. This study aimed to quantify its prevalence, characterize its forms, and identify associated factors in phase III/IV randomized controlled trials (RCTs) of deep brain stimulation (DBS).MethodsWe conducted a cross-sectional analysis…
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Artikel Jurnal
Heterogeneous cognitive and neuroimaging profiles in older adults with type 2 diabetes: the modifying effect of coronary artery disease
BackgroundCognitive impairment in older adults with type 2 diabetes mellitus (T2DM) is increasingly recognized, and coronary artery disease (CAD) is also linked to cognitive decline. However, their combined impact remains underexplored. This exploratory study characterized neurocognitive profiles…
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