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Artikel Jurnal
Methodological innovations in studying marginalized populations in research on neurodegeneration and ageing
Underrepresented populations, often characterized by minority ethnicity, sex/gender or low socioeconomic status, have a higher risk burden and more adverse lifetime experiences of conditions negatively impacting cognitive health than better represented populations. There are several methodological…
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Artikel Jurnal
Pre-plaque glutamatergic hyperexcitability, mitochondrial dysfunction, and dendritic remodeling in the hippocampus of one-month-old 5xFAD mice
Alzheimer’s disease (AD) is characterized by progressive cognitive decline and stereotyped neuropathology, yet the earliest cellular events that precede overt plaque burden and measurable behavioral impairment remain incompletely defined. Here, we tested the hypothesis that synaptic…
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Hippocampal formation–cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task
IntroductionFidelity of detailed information retrieved from long-term memory (LTM) declines in aging due to changes affecting learning and remembering processes. Such behavioral deficits correspond with functional alterations in the hippocampal formation. However, it is unclear whether age-related…
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Neuroinflammation in Alzheimer’s disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies
Alzheimer’s disease (AD) is the most common cause of dementia and major public-health challenge in aging societies worldwide. Accumulating evidence suggests that olfactory and visual deficits can precede overt cognitive symptoms and are closely associated with amyloid-β deposition, pathological tau…
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Artikel Jurnal
Neuromuscular characteristics of dynamic balance control in patients with sarcopenia: a combined analysis of surface electromyography and limits of stability
IntroductionSarcopenia is a major risk factor for falls in older adults; however, the neuromuscular characteristics underlying dynamic balance deficits remain poorly understood.ObjectiveThis study aimed to investigate balance performance and relative muscle contribution patterns in older adults…
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Artikel Jurnal
The association between body composition and orthostatic hypotension in patients with neurodegenerative disorders in parkinsonism-related multidisciplinary clinic
IntroductionOrthostatic hypotension (OH) commonly impairs the quality of life and prognosis of patients with neurodegenerative disorders. Since skeletal muscle functions as a peripheral pump for blood pressure stabilization and a reservoir for intracellular water, we investigated its association…
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Comparative efficacy and certainty of evidence of exercise interventions for cognitive outcomes in older adults with mild cognitive impairment: a systematic review and network meta-analysis of randomized controlled trials
BackgroundMild cognitive impairment (MCI) is common in older adults and is linked to dementia, functional decline, and poorer quality of life. Exercise is recommended as a non-pharmacological strategy, but comparative effects of exercise modalities, alone or combined with cognitive training, remain…
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Integrated PET/MRI for the evaluation of gray matter atrophy and metabolic changes in idiopathic Parkinson’s disease
BackgroundThe underlying mechanisms linking structural and metabolic alterations of idiopathic Parkinson’s disease (IPD) remain poorly understood. Utilizing integrated PET/MR for its precise spatial correlation, this study investigated the temporal relationship between gray matter (GM) atrophy and…
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Artikel Jurnal
Development and validation of a multimodal nomogram predicting anxiety and depression in Parkinson’s disease: integrating plasma biomarkers and clinical phenotypes
IntroductionAnxiety and depression are prevalent, disabling, yet frequently underdiagnosed non-motor symptoms in Parkinson’s disease (PD). This study aimed to develop and validate a non-invasive model predicting these affective disorders by integrating peripheral blood biomarkers with standardized…
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Atherosclerotic-dose TMAO accentuates redox imbalances and motor dysfunctions in a MPTP mouse model of Parkinson’s disease
Parkinson’s Disease (PD) involves the loss of dopaminergic neurons and the formation of Lewy bodies consisting of alpha-synuclein (αSin) aggregates. Trimethylamine N-oxide (TMAO), a gut microbiota metabolite, has emerged as a molecule of interest due to pro-inflammatory, pro-oxidative, and…
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Artikel Jurnal
Nonlinear association between age and verbal fluency and moderation by adiposity: cross-sectional evidence from the Look Up 8+ study
BackgroundVerbal fluency (VF) declines with age, but the shape of this association and its modifiers remain debated. In community-dwelling adults aged 30–80 years from the Look Up 8+ study, we investigated the nonlinear association between age and phonemic VF and evaluated the impact of educational…
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The prognostic potential of circulating BDNF levels and its polymorphisms in age-related cognitive impairment and neurodegeneration
Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, synaptic plasticity, and cognitive function. Age-related decline in BDNF signaling has been implicated in the pathogenesis of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment. However, the prognostic…
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Evolution and trends in tremor diagnosis and differential diagnosis—a bibliometric study
BackgroundTremor is one of the most common motor symptom across movement disorders, and its precise diagnosis has become increasingly critical. However, existing studies remain fragmented. They often focus on specific disease manifestations or isolated diagnostic techniques, but lack systematic…
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Multimodal EEG and explainable machine learning characterize neuroticism-related neurodynamic heterogeneity in mild cognitive impairment during visuospatial working memory
BackgroundAs a personality trait associated with emotional instability and negative emotional tendencies, neuroticism is considered to be closely related to the risk of cognitive decline in old age. However, the neurodynamic abnormalities associated with elevated neuroticism among individuals with…
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Effectiveness of noninvasive brain stimulation techniques on cognitive function in individuals with Alzheimer’s disease and MCI: a systematic review and meta-analysis
BackgroundNoninvasive brain stimulation (NIBS) may alleviate cognitive impairments in individuals with Alzheimer’s disease (AD). However, clinical findings remain inconsistent, highlighting the need for a systematic review and meta-analysis to clarify the efficacy of NIBS.ObjectiveTo compare the…
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Artikel Jurnal
Alterations in static and dynamic topological properties of brain functional network after chronic high altitude exposure: a panel study
BackgroundLong-term exposure to a high-altitude (HA) hypoxic environment induces cognitive impairments, but the underlying mechanisms remain unclear. Notably, the specific topological features of brain networks in this context have not been thoroughly explored. This study investigated graph-based…
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Artikel Jurnal
Artificial intelligence and machine learning for precision prevention of cognitive decline: integrating multimodal biomarkers, lifestyle interventions, and natural medicines from prediction to clinical practice
Cognitive decline and neurodegenerative diseases are progressive, multifactorial conditions that may begin years before overt clinical diagnosis and reflect interactions among biological vulnerability, modifiable exposures, environmental determinants, and reduced brain resilience. This structured…
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Artikel Jurnal
Effects of cognitive workload during motor-cognitive training on executive function, dual-task performance, and posture control: a RCT among middle-aged and older adults
BackgroundFalls are a major concern in geriatric health, and impairments in executive function (EF), gait, and postural control are important fall-related risk factors. Interactive motor-cognitive training (IMCT) has shown promise as an intervention to mitigate these risks. This study aims to…
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Artikel Jurnal
Translating peripheral blood biomarkers into Alzheimer’s disease care: an exploratory dual-pathway model of immune and viral dynamics in behavioral and psychological symptoms of dementia
BackgroundBehavioral and psychological symptoms of dementia (BPSD) critically complicate Alzheimer’s disease care, yet the precise biological correlates for highly heterogeneous symptom domains remain largely unexplored.ObjectiveTo investigate an exploratory “dual-pathway framework” to map how…
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