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Artikel Jurnal
Feasibility and short-term perioperative safety of composite deep cervical lymphatic reconstruction and vagus nerve microneurolysis in Parkinson’s disease: a first-in-indication pilot case series
BackgroundParkinson’s disease (PD) remains associated with motor, non-motor, quality-of-life, and caregiver-burden needs despite pharmacological therapy. Anatomical and translational studies have drawn attention to cervical lymphatic pathways and vagal biology in PD, but surgical manipulation of…
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Artikel Jurnal
Vitamin D neuroimmune synaptic plasticity and precision intervention in pediatric neurodevelopmental disorders
Vitamin D deficiency is highly prevalent in children worldwide but has long been regarded only as a risk factor for bone health. Emerging evidence indicates that vitamin D profoundly influences child brain development by regulating neuroimmune responses and synaptic plasticity, forming a…
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Artikel Jurnal
Alzheimer’s disease polygenic risk score associates with hippocampal subfield atrophy and immune-related genetic mechanism
IntroductionHippocampal atrophy is frequently observed in neurodegenerative diseases such as Alzheimer’s disease (AD) or hippocampal sclerosis of aging (HS-aging). Volume loss in the hippocampus is described as prodromal stage of dementia and has been associated with AD polygenic risk score (PRS)…
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Artikel Jurnal
Impact of exercise on cognitive efficiency in older adults with subjective memory complaints: a randomized clinical trial
IntroductionCerebrovascular dysfunction may contribute to cognitive impairment in older adults. Exercise is recommended for preventing cerebrovascular health and cognition; however, it remains unclear whether cognitive changes are related to changes in cerebrovascular function. Thus, this study…
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Artikel Jurnal
Hearing technology and the brain: cognitive function in different hearing device users
BackgroundThere is an evidence-gap on how different hearing devices influence cognition. This study aimed to simultaneously compare cognitive performance across key domains among hearing aid, cochlear implant and bimodal device users.MethodsCross-sectional data were collected and analyzed as part…
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Artikel Jurnal
Microglia–astrocyte crosstalk as a key organizing principle of Alzheimer’s disease: from homeostatic cooperation to maladaptive signaling loops
Alzheimer’s disease (AD) has long been framed around amyloid-beta (Aβ) and tau pathology, yet mounting evidence indicates that dysfunctional microglia–astrocyte crosstalk is an important, and often underappreciated, contributor to disease progression that operates alongside—rather than in place…
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Artikel Jurnal
Emerging neuroprotective mechanisms and therapeutic potential of natural polysaccharides in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, affecting millions worldwide. Despite extensive research, effective treatments remain limited. Polysaccharides, abundant biological macromolecules derived from natural resources…
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Artikel Jurnal
Abdominal CT-derived metabolic phenotypes are associated with the MRI-derived brain age gap in women
BackgroundMetabolic dysfunction is increasingly recognized as a systemic contributor to adverse brain aging; however, conventional clinical markers may not fully capture tissue-level variations in liver attenuation, abdominal adiposity, and muscle quality. We examined whether abdominal CT-derived…
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Personalized, home-based transcranial alternating current stimulation for memory improvement in mild cognitive impairment: randomized, sham-controlled clinical trial protocol
BackgroundMild cognitive impairment (MCI) is a prodromal stage of Alzheimer’s disease (AD) and represents a critical window for interventions aimed at slowing neurodegenerative progression. Disruptions in neural oscillatory activity are key contributors to memory dysfunction in MCI and AD…
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Artikel Jurnal
From verbal fluency to naturalistic speech: a scoping review of language correlates of loneliness and social isolation in older adults
IntroductionPopulation aging poses significant societal and health challenges, with loneliness and social isolation (L/SI) recognized as pressing public health concerns. While social isolation refers to an objective lack of social contacts, loneliness reflects the subjective perception that one’s…
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Artikel Jurnal
Corticotropin-releasing factor (CRF) in brain aging: from mitochondrial dysfunction to inflammaging
Aging is a complex biological process. The corticotropin-releasing factor (CRF) signaling pathway has gained increasing attention for its potential role in regulating aging, acting as a key bridge connecting neuroendocrine stress mechanisms with both central and peripheral aging processes. As a…
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Artikel Jurnal
Mapping Alzheimer’s disease heterogeneity through exploratory unsupervised learning
IntroductionAlzheimer’s disease (AD) is becoming one of the most pressing health challenges of the century, affecting circa 55 million people worldwide and expected to triple this number by 2050. Besides the growing prevalence, AD remains difficult to diagnose due to its long preclinical phase and…
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Artikel Jurnal
Multilevel functional network signature of Pisa syndrome in Parkinson’s disease: a resting-state fMRI study
BackgroundPisa syndrome (PS) is a disabling postural complication of Parkinson’s disease (PD), but its functional network basis remains insufficiently defined. The aim of this study is to determine whether PD with PS is associated with multilevel resting-state functional network abnormalities…
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Artikel Jurnal
Structural brain changes in the development of essential tremor: toward early diagnosis
BackgroundEssential tremor (ET) is the most common movement disorder. Its etiology and neuropathology remain controversial, but could be clarified with neuroimaging.ObjectivesThis study investigated brain structures derived from T1-weighted MRI associated with tremor severity in analyses focusing…
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Artikel Jurnal
The role of NLRP3 inflammasome in age-related macular degeneration: mechanisms and therapeutic prospects
Age-related macular degeneration (AMD) is a fundus oculi disease that progressively impairs the central vision of patients. To date, its pathogenesis has not been fully elucidated, and therapeutic options for dry AMD remain limited. Recently, chronic low-grade inflammation has been recognized as an…
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Artikel Jurnal
Exercise modalities in mild cognitive impairment: a systematic review and network meta-analysis of comparative effectiveness
BackgroundMild cognitive impairment (MCI) represents an intermediate stage between normal aging and dementia and is associated with an increased risk of progression to dementia. Exercise is a promising non-pharmacological intervention for cognitive decline; however, the comparative effectiveness of…
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Artikel Jurnal
Clinical heterogeneity of Pisa syndrome across Lewy body disorders: a multicenter comparison of Parkinson’s disease and dementia with Lewy bodies
BackgroundPisa syndrome (PS) is well recognized in Parkinson’s disease (PD) but has been less studied in dementia with Lewy bodies (DLB), and direct comparisons are scarce. The aim of this study is to compare the clinical expression of PS across PD and DLB.MethodsIn this multicenter cross-sectional…
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Artikel Jurnal
Fatigue in patients with Parkinson’s disease: a cross-sectional study
ObjectiveThe purpose of this study is to ascertain the incidence of fatigue and to determine the cross-sectional associate and related variables of fatigue in patients with Parkinson’s disease (PD).MethodsA sample of 130 healthy individuals (39.23% male, mean age 64.19 ± 8.70 years) and 130…
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Artikel Jurnal
Which exercise intervention is most promising for Parkinson's balance? A network meta-analysis
ObjectiveParkinson's disease (PD) is a chronic, progressive, and disabling neurodegenerative disorder. While bradykinesia, resting tremor, and rigidity are the cardinal motor symptoms, balance impairments and postural instability frequently emerge during disease progression, substantially…
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Artikel Jurnal
Plaque-associated microglial polarization in visual brain regions of the 5xFAD mouse model
IntroductionAlzheimer’s disease (AD), a neurodegenerative disorder associated with amyloid beta (Aβ) plaque deposition, leads to cognitive decline in affected individuals. Vision changes are among the reported symptoms in AD with studies showing both decline in functions performed by the visual…
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