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Artikel Jurnal
Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia
IntroductionBrain β-amyloid (Aβ) accumulation is a hallmark of Alzheimer’s disease, but noninvasive detection remains challenging. Blood transcriptomics may provide accessible biomarkers associated with Aβ pathology.MethodsWe integrated peripheral blood transcriptomic profiling and MRI-derived…
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Artikel Jurnal
Dual decline in gait and cognition as a high-risk clinical phenotype: differential associations with cerebral amyloid-β deposition and the apolipoprotein E ε4 allele and implications for integrated assessment
BackgroundGait slowing and cognitive impairment often coexist in older adults, yet their relationship with core Alzheimer’s disease (AD) biomarkers remains incompletely understood.ObjectiveTo investigate the associations of isolated and combined slow gait (SG) and cognitive impairment subtypes with…
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Artikel Jurnal
Multivariate associations between systemic inflammation, metabolic dysregulation, and cognitive performance in project FRONTIER
BackgroundCognitive aging is heterogeneous, and growing evidence implicates chronic low-grade inflammation and metabolic dysregulation in neuropathology and cognitive decline. This study examined the multivariate relationship between inflammatory-metabolic biomarkers and neuropsychological…
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Artikel Jurnal
Molecular mechanisms of perimenopausal cognitive impairment in a rat model: multi-omics integration reveals the Adgrl2-Camk2d-TRPV1 signaling axis mediating calcium homeostasis disruption and neuroinflammation
BackgroundPerimenopause represents a pivotal transitional stage in female reproductive aging, often accompanied by neurological disorders such as cognitive decline. However, the underlying molecular mechanisms remain incompletely understood.MethodsIn this study, a total of 18 eight-week-old female…
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Artikel Jurnal
A deep residual attention–Recurrent model for early and multi-stage Alzheimer's disease detection
IntroductionAlzheimer's disease (AD) is a progressive neurodegenerative disorder that requires accurate and early diagnosis. Deep learning methods have shown significant potential for automated MRI-based AD classification.MethodsA hybrid deep learning framework integrating ResNet152V2…
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Artikel Jurnal
Improved YOLOv8 for early detection of Alzheimer’s disease from magnetic resonance imaging
BackgroundAlzheimer’s disease (AD) is a life-threatening condition affecting 47 million people globally, with 13% of them over the age of 65. Despite ongoing efforts in drug development, the incidence of Alzheimer’s disease is increasing, projected to reach 131 million new cases in the next two…
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Artikel Jurnal
The changing epidemiology of infection-associated mortality in Alzheimer’s disease in the United States, 1999–2024
BackgroundInfections are major immediate causes of death in patients with Alzheimer’s disease, trends across infection subtypes remain poorly characterized. We examined temporal trends, demographic geographic disparities, COVID-19-era patterns, projected infection-associated mortality in United…
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Artikel Jurnal
Toward precision neuroscience in Alzheimer’s disease: the role of multimodal AI
BackgroundAlzheimer’s disease (AD) is increasingly understood as a biologically defined and heterogeneous continuum, requiring models that move beyond symptom-based diagnosis toward individualized risk prediction, stratification, and intervention.ObjectiveThis mini-review outlines how precision…
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Artikel Jurnal
Differential detectability of pericyte and blood–brain barrier readouts across the Alzheimer’s disease clinical continuum: a systematic review and meta-analysis
BackgroundIn Alzheimer’s disease (AD), neurovascular unit and blood–brain barrier (BBB) abnormalities are assessed using biologically distinct readouts, often across separate cohorts, complicating interpretation across clinical stages and biomarker domains.MethodsWe searched major databases…
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Artikel Jurnal
Inflammaging and neurovascular unit dysfunction in cognitive ageing: mechanisms, biomarkers, and therapeutic opportunities
Age-related cognitive decline is increasingly recognised as arising from interacting immune and neurovascular vulnerabilities rather than from isolated insults. In this Review, we synthesise current human and mechanistic evidence within a convergence framework in which inflammaging and…
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Artikel Jurnal
Dopamine D3 receptor blockade restores hippocampal synaptic plasticity and rescues memory deficits in Alzheimer's disease mouse models
IntroductionEarly synaptic failure is widely considered a primary driver of cognitive decline in Alzheimer's disease (AD), and previous studies have suggested that dopaminergic signaling may contribute to hippocampal synaptic dysfunction. Among dopaminergic receptors, dopamine D3 receptors (D3Rs)…
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Artikel Jurnal
Emerging biomarkers for Parkinson's disease in biological fluids
Early and accurate diagnosis of Parkinson's disease (PD) remains a challenge, hindering the efficient recruitment of patients into clinical trials aimed at disease modification. This underscores the urgent need for validated and clinically applicable biomarkers. Research continues to expand our…
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Artikel Jurnal
Ultrasound-guided brachial plexus hydrodissection combined with acupotomy release for the treatment of cervical spondylotic radiculopathy: a multicenter retrospective study
IntroductionThe incidence of cervical spondylotic radiculopathy (CSR) remains high. Conventional conservative treatments have limited efficacy in relieving mechanical nerve root compression, while surgery is highly invasive. Both acupotomy release and ultrasound-guided brachial plexus…
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Artikel Jurnal
Chrono-combined aerobic-resistance exercises as therapeutic approach to reverse neurodegeneration in rat model: a detailed protocol
The global increase in neurodegenerative disorders such as Alzheimer’s disease has prompted the search for effective non-pharmacological interventions. Chrono-exercise which is the physical training aligned with circadian rhythms has emerged as a novel strategy to strengthen cognitive resilience…
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Artikel Jurnal
A brief checklist of modifiable dementia risk factors (RF12): associations with cognitive and affective measures in an Italian cohort
IntroductionLow education, hearing loss, traumatic brain injury, hypertension, alcohol abuse, obesity, smoking, depression, social isolation, physical inactivity, air pollution, and diabetes are modifiable lifestyle and experiential factors associated with an increased risk of developing dementia…
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Artikel Jurnal
Latent profile analysis and analytical model construction based on heterogeneity of intrinsic capacity in Chinese older adults
BackgroundIntrinsic capacity (IC) is a critical multidimensional indicator of healthy aging; however, current research on IC primarily emphasizes its longitudinal trajectories, with limited recognition of the heterogeneity within older adults and a notable lack of targeted assessment instruments…
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Artikel Jurnal
Normative age-related changes in resting-state EEG alpha power and theta/alpha ratio across eyes-open and eyes-closed conditions
Resting-state electroencephalography (EEG) provides a sensitive measure of large-scale neural dynamics and has been widely used to characterize age-related changes in brain function. However, many prior studies have relied on relatively small samples or single-condition recordings, limiting the…
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Artikel Jurnal
Amygdala subregion MRI alterations in Parkinson’s disease correlate with olfactory function
ObjectiveOlfactory dysfunction affects 80–90% of Parkinson’s disease (PD) patients. The amygdala, a key olfactory node, comprises functionally distinct subregions. We investigated volumetric changes in nine amygdala subregions across PD stages and their relationship with olfactory…
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