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Caenorhabditis elegans in neuroscience: from neural communication to neurodegenerative disease modeling
Consistent with humans and other metazoans, the nematode Caenorhabditis elegans (C. elegans) undergoes progressive structural and functional decline during aging. Possessing highly conserved genetic pathways that share extensive homology with human genes, and characterized by a streamlined, fully…
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Memory training through Chinese classics recitation for individuals with subjective cognitive decline: study protocol for a pilot study
BackgroundSubjective cognitive decline (SCD) is a preclinical condition associated with an increased risk of dementia and Alzheimer’s disease, with no consensus regarding effective therapeutic interventions to date. As the global burden of aging-related neurodegenerative diseases continues to rise…
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Tactile sensation moderates the association between hand dexterity and higher-level cognition in older adults with and without MCI
BackgroundTactile sensation and hand dexterity decline with age and are associated with later-life cognition, yet it remains unclear whether tactile sensation moderates the strength of hand motor–cognitive associations. This cross-sectional study examines whether tactile sensation moderates the…
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Association of cerebrospinal fluid amphiphysin-1 levels with cognition and Alzheimer’s disease pathology biomarkers
IntroductionAmphiphysin-1 (AMPH), an accessory component of the clathrin-mediated endocytosis (CME) machinery, plays a critical role in synaptic vesicle recycling and membrane dynamics and has been implicated in Alzheimer’s disease (AD) risk. However, its relationship with core AD biomarkers and…
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Serum total cholesterol and low-density lipoprotein cholesterol are associated with Parkinson’s disease in East Asian populations: a bidirectional Mendelian randomization study with complementary animal observation
BackgroundDysregulation of lipid metabolism has been implicated in Parkinson’s disease (PD), yet causal relationships remain unclear due to confounding factors inherent in observational studies. Most Mendelian randomization studies on lipid-PD relationships have been conducted in European…
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Newly emerging IADL impairment predicts subsequent cognitive decline across four population-based aging cohorts
Scalable clinical markers of neurocognitive vulnerability in aging are needed, particularly in settings where biomarker access remains limited. Instrumental activities of daily living (IADLs) capture cognitively demanding everyday behavior and may provide a low-cost, repeatable functional marker of…
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Ventral hippocampal–postcentral gyrus functional connectivity mediates the association of APOE ε4 gene dose, depressive symptoms, and cognitive function in mild cognitive impairment with subsyndromal depression
BackgroundThe apolipoprotein E (APOE) +4 allele is a major genetic risk factor for mild cognitive impairment (MCI) and is associated with hippocampal dysfunction. However, its effects on hippocampal subregional functional connectivity (FC) and clinical manifestations in MCI patients with…
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Advancements in non-pharmaceutical interventions for Alzheimer’s disease management: an update review
Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative condition that is characterized by an increasing incidence rate due to global population aging, resulting in a significant social and economic burden. Current pharmacological interventions offer only limited relief and are unable…
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TyG index and mild cognitive impairment and dementia: a review of current evidence
This narrative review aimed to synthesize current epidemiological, mechanistic, and clinical evidence on the association between the triglyceride-glucose (TyG) index and cognitive impairment, and to discuss its potential role in metabolic–neurocognitive risk assessment. Current evidence from cohort…
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Oxidative stress as a driver of organelle cascade damage in neurological diseases
As a core driver in the pathological progression of neurological diseases, oxidative stress contributes to the onset and development of multiple disorders, including traumatic brain injury (TBI), Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral…
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Artikel Jurnal
The impact of long-term antiseizure treatment on cognitive decline in late-onset epileptic prodromal Alzheimer’s disease: an exploratory study
BackgroundThe well-documented bidirectional relationship between Alzheimer’s disease (AD) and epilepsy suggests that seizures are not merely a complication of AD but may also contribute to disease progression. Emerging evidence indicates that antiseizure medications (ASMs) could potentially slow…
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Association between BDNF and postoperative cognitive dysfunction across surgical stages: a systematic review and meta-analysis
Postoperative cognitive dysfunction (POCD) is a frequent complication after surgery, particularly among older adults, and its underlying mechanisms remain incompletely understood. Brain-derived neurotrophic factor (BDNF) is a key regulator of neuronal survival and synaptic plasticity, and has been…
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Effects of transmembrane protein 106B genetic variations on disease progression in Parkinson’s disease
BackgroundTransmembrane protein 106B (TMEM106B) variations not only act as genetic modifiers of the risk of developing frontotemporal lobar degeneration but also correlate with the heterogeneity of clinicopathological phenotypes in other neurodegenerative diseases. However, the roles of TMEM106B in…
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Association of acute-phase plasma pTau217 levels with long-term post-stroke cognitive impairment
BackgroundPost-stroke cognitive impairment (PSCI) is a common complication affecting stroke survivors, yet early biomarkers for risk stratification remain scarce. Plasma pTau217 has emerged as a specific biomarker for Alzheimer’s disease pathology. This study explores whether acute-phase pTau217…
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Ferroptosis-related biomarkers for diagnosis and mechanistic insights into Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) lacks reliable early diagnostic biomarkers and effective disease-modifying therapies. Ferroptosis has been increasingly implicated in AD pathogenesis; however, ferroptosis-related genes with diagnostic and mechanistic relevance remain insufficiently…
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Artikel Jurnal
APOE ε4, physical activity, and the brain: a review of systematic reviews
BackgroundPhysical activity (PA) is often proposed as a modifiable strategy to reduce cognitive decline and dementia risk, particularly among individuals at elevated genetic risk for Alzheimer’s disease (AD). However, it remains unclear whether the existing literature tests PA at the disease stage…
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Artikel Jurnal
The Vall d’Hebron Initiative for Parkinson (VHIP) cohort: a prospective, longitudinal, and observational study enrolling de novo Parkinson’s disease patients for biomarker identification and validation
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder causing a variety of motor and non-motor symptoms. To date, no disease modifying treatment exists, and diagnosis is based on the manifestation of the clinical motor symptoms, which occurs when the neurodegenerative…
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Disrupted structural covariance network in presbycusis patients: evidence from a large sample mri-based morphometric study
BackgroundPresbycusis is characterized by progressive age-related hearing loss and is often associated with cognitive decline and mental health disorders.ObjectiveThis study aimed to investigate gray matter volume (GMV) alterations and structural covariance network (SCN) reorganization in…
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Artikel Jurnal
Effect of increasing cognitive activity participation via calligraphy practice on salient network and central executive network in older adults with subjective cognitive decline: a secondary analysis of a randomized controlled trial
ObjectivesRegular participation in late-life cognitive activities is associated with a reduced risk of dementia. In a prior randomized controlled trial, we demonstrated that increased calligraphy practice improved working memory and strengthened functional connectivity (FC) within the default mode…
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