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Artikel Jurnal
Creating cognitive normative data for rural Indian population
IntroductionPopulation-specific normative data are essential for accurately interpreting cognitive test performance, particularly in low-resource settings characterized by low literacy rates. In India, normative values for the Indian Council of Medical Research-Neurocognitive Tool Box (ICMR-NCTB)…
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Artikel Jurnal
Nurse-led non-pharmacological interventions for cognitive improvement in dementia patients: a systematic review and meta-analysis of randomized controlled trials
IntroductionNurse-led non-pharmacological interventions (NLNPIs) have gradually been recognized as a safe strategy to improve cognitive function in patients with dementia. Nevertheless, current research findings remain controversial and the adequacy of sample sizes in previous investigations has…
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Artikel Jurnal
AI-enabled multimodal neuroimaging for neurotransmitter mapping in normal aging and age-related disease
Aging reshapes neurotransmitter systems through nonlinear and region-specific shifts that alter excitatory–inhibitory balance, weaken metabolic coupling, and destabilize large-scale neural networks. PET, MRS, molecular MRI, and optical imaging quantify elements of these trajectories, but…
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Artikel Jurnal
Amyloid-β modulates APOE ε4 effects on cognition but not on targeted structural or functional connectivity measures over 2 years in pre-dementia adults
BackgroundThe apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet emerging evidence suggests its cognitive effects may be age- and pathology-dependent. Whether and how amyloid-β (Aβ) pathology modifies the longitudinal cognitive…
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Artikel Jurnal
Microstructural white matter alterations in dementia with lewy bodies and Alzheimer’s disease: a diffusion tensor imaging and neurite orientation dispersion and density imaging study
BackgroundDementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are common types of dementia, however, diagnosis is challenging. An innovative MR method called neurite orientation dispersion and density imaging (NODDI) is used to assess different microstructural alterations between the…
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Artikel Jurnal
Age-group differences between young and middle-aged adults in spatiotemporal EEG dynamics revealed by instantaneous frequency microstate analysis
IntroductionThe human brain exhibits complex functions that emerge from interactions among spatially distributed neural regions. Electroencephalography (EEG) microstate analysis has been widely adopted to capture transient topographies reflecting large-scale network dynamics; moreover, it has been…
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Artikel Jurnal
Treg–microglia crosstalk in Alzheimer’s disease: stage-dependent dynamics, molecular mechanisms, and translational challenge
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) deposition, tau hyperphosphorylation, and chronic neuroinflammation. Emerging evidence from preclinical models suggests that aberrant immune crosstalk between regulatory T cells (Tregs) and microglia may contribute to disease…
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Artikel Jurnal
Glymphatic-related imaging findings in type 2 diabetes mellitus: a systematic review and exploratory meta-analysis of DTI-ALPS studies
BackgroundType 2 diabetes mellitus (T2DM) is associated with white matter microstructural, neurovascular, and cognitive changes. Perivascular fluid dynamics may also be altered in T2DM. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is an indirect imaging measure…
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Artikel Jurnal
NEK1 variants and reduced protein levels in Chinese ALS patients: a descriptive study
ObjectiveNIMA-related kinase 1 (NEK1) have been implicated in amyotrophic lateral sclerosis (ALS). But genetic spectrum and clinical presentation have not been systematically defined.MethodsWe screened 378 ALS patients and identified NEK1 variant carriers. Clinical records were reviewed…
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Artikel Jurnal
Recurrence quantification analysis of gait for computer-aided diagnosis of Parkinson's disease
IntroductionParkinson's disease (PD) is a typical neurodegenerative disorder characterized by progressive motor impairments. Gait analysis offers a promising avenue for non-invasive PD diagnosis, yet extracting discriminative features from gait signals remains challenging.MethodsThis study proposed…
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Artikel Jurnal
The cellular choreography of brain aging: a neuroimmune network perspective
Brain aging is increasingly recognized as a heterogeneous and systems-level process involving dynamic interactions among neuronal, glial, vascular, and immune-associated cell populations. Recent advances in single-cell and spatial omics technologies have revealed diverse cellular aging…
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Artikel Jurnal
N-terminal modifications as fate switches in neurodegeneration: a mechanistic review
The accumulation of aberrant proteins or their impaired clearance leads to neurodegenerative diseases (NDs). The protein amino terminus (Nt) and its modifications determine the fate of proteins and their cellular effects. Nt acetylation, Nt methylation, and Nt myristoylation are protein Nt…
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Artikel Jurnal
Semaglutide in cognitive dysfunction: neuroprotective potential, clinical trial limitations, and a prevention-focused framework
Metabolic dysfunction is increasingly recognized as a pivotal factor in cognitive decline and neurodegenerative diseases, such as Alzheimer’s disease (AD). Glucagon-like peptide-1 receptor agonists (GLP-1RAs), notably the long-acting agonist semaglutide, exhibit significant metabolic efficacy and…
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Artikel Jurnal
Magnetic resonance imaging volumetry in atypical parkinsonism: current evidence and neuroradiological perspectives
Atypical parkinsonism, including progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal syndrome (CBS), represents a major diagnostic challenge, particularly in the early stages of disease. Magnetic resonance imaging (MRI) plays a pivotal role in the differential…
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Artikel Jurnal
Systematic proteomics reveals plasma NEFL as a robust predictor and pathological associate in C9ORF72-related neurodegeneration
BackgroundThe C9ORF72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). While neurofilament light chain (NEFL) is an established biomarker of neuroaxonal damage, its specific dose-response relationship with the C9ORF72…
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Artikel Jurnal
Effects of combined Mediterranean diet and physical activity intervention on the gut microbiome and disease progression in individuals with Parkinson’s disease: study protocol for a multicenter, randomized controlled pilot study (PRIME study)
Background and aimsParkinson’s disease (PD) is a neurodegenerative disorder for which no disease-modifying therapy currently exists, making it crucial to investigate alternative strategies that may slow its progression. The PRIME study will investigate the effects of combined dietary and physical…
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Artikel Jurnal
Exercise-based modulation of the gut-brain axis: a new direction for neurorehabilitation in Alzheimer’s disease
Gut microbiota dysbiosis contributes to the development of Alzheimer’s disease (AD) through gut-brain axis mediated processes, including neuroinflammation, β-amyloid (Aβ) accumulation, tau hyperphosphorylation, disruption of the blood-brain barrier, and progressive cognitive impairment. Exercise…
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