8.223 hasil
Menampilkan 541–560 · 0,16 detik · RSS
-
Artikel Jurnal
Blood–brain barrier vulnerability and microcirculatory dysfunction as predictors of hemorrhagic transformation after endovascular treatment in acute ischemic stroke
BackgroundHemorrhagic transformation (HT) after endovascular treatment (EVT) for acute ischemic stroke (AIS) remains a major clinical challenge, particularly in populations vulnerable to vascular and endothelial injury. Beyond conventional clinical predictors, microcirculatory dysfunction and…
-
Artikel Jurnal
Mindfulness-based stress reduction combined with reminiscence therapy: a non-pharmacological approach for older adults with mild cognitive impairment or mild dementia due to Alzheimer’s disease
ObjectivesNon-pharmacological approaches are preferable to improve functional capacity and reduce emotional disorders for dementia patients with cognitive decline. This study aimed to assess the effectiveness of mindfulness-based stress reduction (MBSR) combined with reminiscence therapy (RT) on…
-
Artikel Jurnal
Lipid dysregulation as a convergent pathway linking environmental exposures to stroke
Stroke remains the second leading cause of death globally, yet traditional risk factors explain only 50–60 percent of cases. Emerging evidence indicates that lipid dysregulation is a central mechanism linking environmental exposures to cerebrovascular vulnerability. Aging, chronic inflammation…
-
Artikel Jurnal
Predictive value of the fibrinogen-to-high-density lipoprotein cholesterol ratio for sub-clinical diabetic peripheral neuropathy in type 2 diabetes mellitus
IntroductionThis study aims to investigate the predictive value of the fibrinogen-to-high-density lipoprotein cholesterol ratio (FHR) in relation to sub-clinical diabetic peripheral neuropathy (sDPN) in individuals diagnosed with type 2 diabetes mellitus (T2DM).MethodsA cohort of 281 patients with…
-
Artikel Jurnal
Different stages of Alzheimer’s disease with periodontitis: clinical features and potential mechanisms involving gingipains, neuropathological biomarkers and neurological damage
BackgroundAlzheimer’s disease (AD) and periodontitis are common in older adults aged over 65 years. However, the clinical features and mechanisms at the stages of mild cognitive impairment and dementia due to AD (AD-MCI and AD-D) remain unknown.MethodsIn 110 patients with AD-MCI and AD-D, oral…
-
Artikel Jurnal
Resting-state brain activity and association with physical activity
IntroductionNormal aging is associated with alterations of functional connectivity in brain neuronal networks. Altered network connectivity may be associated with accelerated cognitive decline. Physical activity is considered a beneficial lifestyle factor for maintaining cognitive health. Higher…
-
Artikel Jurnal
Construction of a classification model for dementia among Brazilian adults aged 50 and over
BackgroundDementia is a multifactorial and debilitating condition marked by cognitive decline and behavioral changes that compromise independence and daily activities. This condition is a growing challenge in Brazil, and early identification of associated factors can guide preventive strategies and…
-
Artikel Jurnal
Amyloid beta pathology induces astrocytic pTDP-43 mislocalization and disrupts TDP-43-regulated cryptic exon transcripts
BackgroundWhile amyloid-β (Aβ) and tau are hallmark pathologies of Alzheimer’s disease (AD), TDP-43 proteinopathy is increasingly recognized as an important contributor, occurring in up to 57% of AD cases and associated with accelerated cognitive decline. TDP-43 regulates RNA splicing, and its…
-
Artikel Jurnal
Development and validation of a nomogram for predicting the risk of shoulder-hand syndrome after ischemic stroke: a retrospective study
ObjectiveThis study aims to assess the relevant risk factors and construct a nomogram model to assist in the early identification of shoulder-hand syndrome (SHS) after ischemic stroke.MethodOne thousand five hundred and thirty-nine ischemic stroke patients admitted to the First People’s Hospital of…
-
Artikel Jurnal
New trends and hotspots in Sepsis-associated encephalopathy research: a bibliometric and visualization analysis
ObjectiveTo systematically map the global and domestic research landscape of sepsis-associated encephalopathy (SAE) and to identify current hotspots and future trends.MethodsRelevant articles published from 1 January 2000, to 1 August 2025 were retrieved from the Web of Science (WoS) Core…
-
Artikel Jurnal
Aged female and male C57BL/6J mice have reduced alcohol self-administration and altered acute alcohol withdrawal compared to younger animals
IntroductionAs the age of the world’s population continues to increase it is important to investigate behaviors, such as alcohol consumption, that may negatively impact the health of the older population.MaterialsIn the present study, aged, young adult and adolescent female and male C57BL/6J mice…
-
Artikel Jurnal
Astrocytic K+ regulation during neurodegenerative diseases
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in specific areas of the central nervous system. Historically, a “neurocentric” paradigm viewed glial cells, such as astrocytes, as cells that provided adequate support for neuronal…
-
Artikel Jurnal
Effects of aerobic exercise and computer-based cognitive training on cognition, functional independence, quality of life, and salivary cortisol levels in older adults with mild cognitive impairment: a randomized trial
BackgroundMild Cognitive Impairment (MCI) represents an intermediate stage between normal aging and dementia, characterized by measurable cognitive decline without significant loss of functional independence. Non-pharmacological interventions, particularly aerobic exercise and cognitive training…
-
Artikel Jurnal
The role of healthy lifestyle in the association between hepatic fibro-inflammation and steatosis and brain aging—a cross-sectional study
BackgroundThis study investigated the association between liver fat, liver fibro-inflammation, and brain age, and assessed whether modifiable lifestyle factors modified the associations between liver markers and brain age.MethodsA total of 19,566 adults free from dementia and other neurological…
-
Artikel Jurnal
PPARG as a central regulator of ferroptosis in Alzheimer’s disease: integrated transcriptomic, single-cell, and experimental evidence
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, β-amyloid (Aβ) plaque accumulation, neurofibrillary tangle formation, and chronic neuroinflammation. Increasing evidence suggests that ferroptosis, an iron-dependent form of regulated…
-
Artikel Jurnal
Glial lactate metabolism and transport in Alzheimer’s disease
Emerging evidence suggests that lactate, once considered merely a metabolic byproduct, plays vital roles in brain energy metabolism, signaling, and neuroprotection. In Alzheimer’s disease (AD), increasing research has implicated disruptions in glial lactate metabolism and transport as key…
-
Artikel Jurnal
Ultra-fast MRI for brain-age prediction in a real-world cognitive disorders clinic
IntroductionAlzheimer’s trials and memory-clinic workflows require frequent structural MRI, but standard 3D-T1 MPRAGE can be burdensome and motion-prone. The Wave-CAIPI sequence offers major time savings, yet it is unclear whether these ultra-fast scans can be used to derive dementia-related…
-
Artikel Jurnal
Development of Alzheimer’s disease risk score for future integrated primary care: a white-box approach
IntroductionReceiving timely Alzheimer’s disease (AD) diagnosis is often delayed due to long waitlists for specialists. Our study aimed to bridge the gap between the timeliness and complexity of diagnosing AD by developing a scoring system with interpretable machine learning using variables that…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.