8.223 hasil
Menampilkan 561–580 · 0,15 detik · RSS
-
Artikel Jurnal
Studying neurocognitive systems for sustained attention in neurogeriatric patients: protocol of the SENSE-AGE study
BackgroundSustained attention is a complex cognitive function required for the successful performance of tasks such as walking, cycling, driving, conversations and other prolonged tasks. Deficits of this function are associated with frailty, falls, and general cognitive decline in older adults…
-
Artikel Jurnal
Myofascial pain in older adults: a geroscience-informed framework integrating precision geriatrics and digital therapeutics
Myofascial pain syndrome (MPS) in the elderly is a significant contributor to chronic pain and functional decline, driven by a unique set of age-related pathophysiological challenges. Core geroscience principles—including sarcopenia, inflammaging, and cellular senescence—converge to create a state…
-
Artikel Jurnal
Sex-specific gray matter underpinnings of anxiety and their mediating mechanisms in de novo Parkinson’s disease
ObjectiveAnxiety is a prevalent non-motor symptom in Parkinson’s disease (PD) with observed sex differences. This study aimed to investigate sex-specific gray matter volume (GMV) associations with anxiety and preliminarily explore the potential mediating role of these regional GMV alterations in…
-
Artikel Jurnal
Two-year trajectory of cognitive decline and neurological sequelae in COVID-19 survivors with acute neurological symptoms
IntroductionThe COVID-19 pandemic caused by SARS-CoV-2 has profound implications for global public health. It significantly affects the nervous system and cognitive function. The emergence of long COVID has raised concerns regarding long-term cognitive impairment, particularly among patients who…
-
Artikel Jurnal
Plasma chaperone-mediated autophagy associated protein HSPA8 combined with white matter hyperintensities serves as the predictive marker of early-stage Alzheimer’s disease
BackgroundThe relationship between plasma chaperone-related autophagy proteins and white matter hyperintensity (WMH) in Alzheimer’s disease (AD) remains unclear.MethodsWe employed 4D-DIA proteomics to identify plasma protein changes, and evaluated the clinical relevance of the chaperone-mediated…
-
Artikel Jurnal
Early detection of Alzheimer’s disease via multimodal MRI and machine learning
ObjectiveThis study aimed to identify effective biomarkers associated with early-stage Alzheimer’s disease (AD) by integrating multimodal neuroimaging features with machine learning (ML), addressing clinical challenges posed by global population aging.Materials and methodsMultimodal…
-
Artikel Jurnal
Beyond lifespan and healthspan: a biological framework for experienced longevity
Aging research has traditionally focused on lifespan and healthspan as primary outcome domains, implicitly treating chronological time as a uniform container of value. The memory-structured reconstruction of extended chronological intervals has not been systematically examined as an aging-related…
-
Artikel Jurnal
Exercise suppresses apoptosis for alleviating Parkinson’s disease: effects on pathophysiological molecular pathways
Parkinson’s disease (PD) is characterized by the progressive degeneration of midbrain dopaminergic neurons, with apoptosis representing the predominant mechanism of neuronal cell death among the various forms of cell death implicated in PD. The lack of effective strategies to inhibit neuronal…
-
Artikel Jurnal
Incidence, outcomes and risk factors of rebound neurological deterioration after initial improvement following intravenous thrombolysis: a retrospective cohort study
IntroductionIn clinical practice, a substantial number of acute ischemic stroke (AIS) patients experience neurological deterioration following by initial early neurological improvement (ENI) after intravenous thrombolysis (IVT), a pattern we define as rebound neurological deterioration (REND)…
-
Artikel Jurnal
Distinct patterns of spontaneous brain activity in mild cognitive impairment patients stratified by cerebrospinal fluid biomarkers
BackgroundThis study aimed to explore the alterations in the Amplitude of Low-Frequency Fluctuation (ALFF) among mild cognitive impairment (MCI) patients with varying cerebrospinal fluid (CSF) biomarker levels, including abnormal Amyloid-beta (Aβ42) and phosphorylated tau protein (p-tau) (A + T +)…
-
Artikel Jurnal
Long-term outcomes after caudal zona incerta-forel field ablation: three-year clinical follow-up in advanced Parkinson’s disease
IntroductionAdvanced Parkinson’s disease (PD) with a tremor–rigid phenotype poses therapeutic challenges when pharmacological treatments lose efficacy and deep brain stimulation (DBS) is not an option; particularly in contexts where access to implantable neuromodulation therapies is limited. In…
-
Artikel Jurnal
Association between pre-diagnostic prevalence of 30 common diseases and the subsequent risk of dementia: a population-based retrospective cohort study in Taiwan
BackgroundDementia associates with long-term progression, but the health status of individuals years before diagnosis remains poorly understood. We therefore conducted a large retrospective cohort study to examine the association between early-life morbidity and incident dementia.MethodsWe designed…
-
Artikel Jurnal
Impact of Lewy body and limbic-predominant TDP-43 neuropathology on cognitive and neuropsychiatric trajectory in Alzheimer’s disease: a retrospective neuropathological study
IntroductionAlzheimer’s disease (AD) is the leading cause of neurodegenerative dementia, and mixed neuropathological changes including Lewy body (LB-NC) and TDP-43 (LATE-NC) are commonly observed in patients with AD. We examined the baseline cross-sectional and longitudinal effects of these…
-
Artikel Jurnal
Structural and functional brain alterations in depression with Alzheimer’s disease and mild cognitive impairment: a multimodal coordinate-based meta-analysis
BackgroundDepression is a common neuropsychiatric symptom in Alzheimer’s Disease (AD) and mild cognitive impairment (MCI). Inconsistent results for comparison between AD with depression (ADD), MCI with depression (MCID), and those without depression were obtained from previous neuroimaging studies…
-
Artikel Jurnal
Progression of GBA1 severe and risk variants: a longitudinal mixed model analysis
IntroductionAn association between severe GBA1 variants and the progression of non-motor symptoms in PD has been reported, but the role of Parkinson’s-risk (PD-risk) GBA1 variants is less clear.MethodsWe assessed symptom progression in individuals with severe and PD-risk variants compared to…
-
Artikel Jurnal
Amantadine-based combination therapy of Parkinson’s disease to prevent fluctuation and dyskinesia – experiences from a Parkinson outpatient clinic
BackgroundThe standard therapy of Parkinson’s disease consists in supplementing the depleted dopamine with oral levodopa. The disadvantages of the levodopa monotherapy – comparable to other dopaminergic substances – are the dose-dependent development of dyskinesia in ON-phases, and bradykinesia and…
-
Artikel Jurnal
Systemic proteomic and organ aging signatures associated with plasma Aβ oligomerization in a Korean cohort: a cross-sectional study
BackgroundAlzheimer’s disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) in the brain, which begins decades before the appearance of clinical symptoms. Blood from AD patients, when spiked with synthetic Aβ, exhibited a higher Aβ oligomerization tendency (OAβT) than the non-AD…
-
Artikel Jurnal
Corneal epithelial thickness can reflect the stage of Parkinson’s disease and the severity of dry eye
PurposeTo systematically analyze corneal epithelial thickness (CET) distribution in Parkinson’s disease (PD) using anterior segment optical coherence tomography (AS-OCT) and investigate its correlation with disease stage and dry eye severity.MethodsThis cross-sectional study enrolled 60 PD patients…
-
Artikel Jurnal
Neural and motor mechanisms of handwriting: from healthy aging to neurodegenerative disorders
Handwriting is a complex cognitive and motor skill supported by a distributed brain network involving cortical, subcortical, and cerebellar regions responsible for planning, execution, and sensorimotor integration. Beyond its communicative role, handwriting provides biologically meaningful…
-
Artikel Jurnal
Mitochondrial dysfunction in Alzheimer's disease and related sex differences
Alzheimer's disease (AD), the most common form of dementia, accounts for 70% of cases and remains a major healthcare challenge due to its rising prevalence and lack of disease-modifying treatments. Clinically, AD is a sexually dimorphic disease. Women exhibit more rapid cognitive decline and…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.