8,223 results
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Journal Article
Multimodal neuroimaging discrimination of Alzheimer’s disease, mild cognitive impairment, and late-life depression using electroencephalography and functional near-infrared spectroscopy: integrating electrophysiological and hemodynamic biomarkers
ObjectiveTo identify electrophysiological and hemodynamic characteristics of the cerebral cortex during the resting-state that could help differentiate Alzheimer’s disease (AD), mild cognitive impairment (MCI), and late-life depression (LLD) and integrate these characteristics into a diagnostic…
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Journal Article
Transcranial direct current stimulation to improve cognitive function in patients with vascular cognitive impairment: a literature review
Vascular pathology represents the second most common cause of cognitive impairment after Alzheimer’s disease and contributes substantially to mixed dementia involving both vascular and neurodegenerative mechanisms. Vascular cognitive impairment (VCI) emerges as a term encompassing cognitive…
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Journal Article
Associations of anticholinergic burden of medication with cognitive decline and longitudinal brain atrophy in the Alzheimer’s disease spectrum
BackgroundAnticholinergic side effects of pharmacological treatment are a risk factor for cognitive decline in older people. Here, we aimed to assess the effect of anticholinergic burden of treatment on longitudinal rates of cognitive change and atrophy in functionally related brain regions in…
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Journal Article
Solid lipid nanoparticles as carriers for Ulva rigida peptide extract with demonstrated anti-β-amyloid and antioxidant properties
IntroductionAlzheimer’s disease (AD) remains one of the greatest challenges in neurodegenerative research, largely due to the toxic aggregation of the β-amyloid (Aβ) peptide and the difficulty of delivering therapeutic compounds across the blood-brain barrier (BBB).MethodsThis work explored Ulva…
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Journal Article
40-Hz transauricular vagal nerve stimulation rescues cognition of 9-month-old APP/PS1 mice via inhibiting hippocampal P2X7 receptor signaling
The lack of any viable therapy for Alzheimer’s disease (AD) evoked the study and utilization of neuromodulation. 40-Hz transauricular vagal nerve stimulation (taVNS) preliminarily showed effectiveness in mice with partial cognitive impairment in our previous work, yet 3 major problems remained…
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Journal Article
Molecular mechanism of Alzheimer’s disease using integrated multi-omics
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder driven by complex interactions between neuroinflammation, immune dysregulation, metabolic impairment, and disrupted synaptic plasticity. Emerging evidence highlights maladaptive microglial activation, chronic cytokine signaling…
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Journal Article
Examination of shared gut microbiome signatures in aging and Parkinson’s disease
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that is characterized clinically by a constellation of motoric deficits including resting tremors, bradykinesia, and rigidity. In recent years, there has been increasing interest in the gut-brain axis with several studies examining…
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Journal Article
Efficacy of Dang Gui Shao Yao San in treating vascular dementia in animal models: a systematic review and meta-analysis
BackgroundVascular dementia (VaD) is the second most prevalent form of dementia, following Alzheimer’s disease (AD), and severely impacts life quality of patients. Currently, effective strategies to alleviate symptoms and delay disease progression remain unavailable. Animal studies indicate that…
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Journal Article
Cross-sectional and longitudinal functional network alterations associated with subthreshold depressive symptoms in healthy older adults
ObjectiveSubthreshold depressive symptoms (SDS) in older adults as a prodromal state of late-life depression (LLD) increase with age and are associated with elevated risk for cardio- and cerebrovascular diseases. LLD has been linked to functional brain network disruptions, including the ventral…
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Journal Article
Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor
BackgroundPerivascular diffusion holds great potential for the non-invasive assessment of the glymphatic system (GS). However, Gaussian model-based diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is limited by microstructural alterations. This study aimed to compare…
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Journal Article
Telomere dysfunction is associated with exacerbated intermittent hypoxia-induced cognitive deficits and nerve damage
Cognitive impairment associated with obstructive sleep apnea (OSA) is more prevalent and severe in the elderly, possibly due to age-related increases in neuronal susceptibility to intermittent hypoxia (IH). As telomere dysfunction is a key driver of cellular aging, this study aimed to characterize…
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Journal Article
Molecular mechanisms underlying exercise-enhanced autophagy in improving neuroplasticity in Alzheimer’s disease
Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by progressive memory impairment and cognitive dysfunction. The neuropathological hallmarks of this neurodegenerative disorder encompass two principal pathological features: extracellular deposition of amyloid-β (Aβ)…
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Journal Article
Standardized protocol for plasticity assessment in the aging mouse neocortex using choline-chloride perfusion
Age-related changes in synaptic function are central to the progression of brain pathologies, including neurodegenerative diseases, underscoring the need for experimental approaches that capture neuronal properties across the lifespan. However, obtaining high-quality tissue preparations from aged…
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Journal Article
Multimodal data-driven eye-movement subtypes and their cerebral glucose metabolic patterns in Parkinson’s disease
BackgroundPreviously reported Parkinson’s disease (PD) subtyping schemes often show limited stability and cross-cohort generalizability.ObjectiveTo derive data-driven oculomotor subtypes in PD using multi-task eye-movement assessment and to characterize their cerebral glucose metabolic…
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Journal Article
Cognitive improvement by non-pharmacological electrical stimulation modalities in mild cognitive impairment: a protocol for systematic review and network meta-analysis
ObjectiveMild cognitive impairment, characterized by progressive cognitive decline, represents a prevalent transitional state among the global aging population and demonstrates high conversion rates to Alzheimer’s disease, establishing itself as a critical window for preventive interventions…
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Journal Article
Microglia associated research in depression: an exploratory trends analysis
BackgroundDepression is a common and highly debilitating severe affective disorder. Relevant studies have indicated that microglia are closely associated with the progression of depression. This study conducts a bibliometric analysis on the research related to microglia in depression, aiming to…
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Journal Article
Liver–metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the dementia platform Korea trial-ready registry
IntroductionLiver–metabolic stress and apolipoprotein E (APOE) ε4 are implicated in late-life cognitive vulnerability, yet how hepatic–metabolic indices relate to cognition and amyloid burden and whether these associations vary by APOE ε4 allele dose remains unclear. We examined liver–metabolic…
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Journal Article
Virtual reality-based cognitive training in mild cognitive impairment: a systematic review
IntroductionMild cognitive impairment (MCI) is recognized as a transitional phase preceding dementia and represents a crucial window for intervention. Conventional cognitive training (CCT) often lacks engagement and sustained participation, limiting its effectiveness in slowing cognitive decline…
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Journal Article
Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults
IntroductionSleep quality is often thought to be a key determinant of cognitive performance, particularly in older adults who experience age-related changes in sleep architecture. However, the extent to which nightly variations in sleep quality impact next-day cognitive performance remains…
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Journal Article
The role of glutathione in cognition, cognitive effort, and cognitive endurance in young and older adults
Glutathione (GSH) is an abundant antioxidant that protects against endogenous and exogenous toxic agents. The evidence over the relationship between GSH and cognitive integrity during aging is still scarce. In this study we investigated the relationship between GSH and cognitive integrity…
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