8.223 hasil
Menampilkan 581–600 · 0,35 detik · RSS
-
Artikel Jurnal
Effects of brain-computer interface-based rehabilitation on upper limb function, activities of daily living, and adverse events in patients with early stroke: a systematic review and meta-analysis
BackgroundBrain-computer interface-based rehabilitation represents an emerging neurorehabilitation approach for post-stroke motor recovery, yet its comprehensive effects on patients in the early phase after stroke, typically defined as within 3 months of onset, remain to be fully established. This…
-
Artikel Jurnal
Intervention of ginseng-derived macromolecular drugs in Alzheimer’s disease: exploring mechanisms and assessing potential
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder for which effective treatments remain elusive. This review aims to explore the roles, mechanisms, and therapeutic potential of three principal ginseng components, including ginseng polysaccharides (GPS), ginseng proteins (GP), and…
-
Artikel Jurnal
Esketamine ameliorates postoperative cognitive dysfunction aggravated by preoperative acute sleep deprivation in aged mice via the TLR4/NF-κB pathway
IntroductionPostoperative cognitive dysfunction (POCD) is a common complication in elderly patients, and preoperative sleep deprivation may exacerbate its severity. Although earlier research has confirmed that esketamine can reduce the incidence of POCD, it remains unclear whether it is effective…
-
Artikel Jurnal
Interleukin-6, CD8+ T cells, and Alzheimer’s disease: unraveling neuroimmune crosstalk via genetic and mechanistic insights
Alzheimer’s disease (AD) is a neurodegenerative disorder with complex interplay between neuroinflammation and immune dysfunction. Interleukin-6 (IL-6), a pleiotropic cytokine, has emerged as a controversial player in AD pathogenesis, with conflicting roles reported in inflammation and…
-
Artikel Jurnal
Neuroprotective role of bilirubin in Parkinson's disease
IntroductionThe progressive loss of dopaminergic neurons in the nigrostriatal pathway, driven by mechanisms such as oxidative stress, neuroinflammation, and ferroptosis, represents a hallmark of Parkinson's disease (PD). Notably, physiological or mildly elevated bilirubin levels demonstrate potent…
-
Artikel Jurnal
Deep learning-based detection of cerebral microbleeds on 2D T2*-weighted GRE MRI: toward ARIA-H risk assessment in Alzheimer’s treatment
BackgroundAmyloid-related imaging abnormalities with hemorrhage (ARIA-H) are a key safety concern in anti-amyloid therapies for Alzheimer’s disease, as they are radiologically indistinguishable from cerebral microbleeds (CMBs). Accurate detection of CMBs is therefore essential for both treatment…
-
Artikel Jurnal
Protein lactylation in Alzheimer’s disease: bridging metabolism, pathology, and therapeutic opportunity
Lactate, long regarded as a mere by-product of glycolysis, is increasingly recognized as a signaling metabolite and epigenetic regulator through protein lactylation. This lysine-specific post-translational modification functionally couples cellular metabolic states to gene regulatory programs and…
-
Artikel Jurnal
The mechanism of external cueing interventions in improving freezing of gait in Parkinson’s disease: an fNIRS study
IntroductionExternal cue interventions can effectively improve gait disturbances in patients with Parkinson’s Disease (PD) and Freezing of Gait (FOG). However, the cortical mechanisms underlying cueing modulation of gait have rarely been investigated.ObjectivesWe aimed to compare gait performance…
-
Artikel Jurnal
Distinguishing early from late mild cognitive impairment: a multi-level analysis of regional morphometry and KLS-derived network topology
IntroductionDistinguishing between early Mild Cognitive Impairment (EMCI) and late mild cognitive impairment (LMCI) is crucial for clinical trials, but objective biomarkers are lacking. We therefore examined regional morphometry and network topology across cognitively normal (CN), EMCI, and LMCI…
-
Artikel Jurnal
Intraventricular hemorrhage, suspected EBV reactivation, and TBA-positive epilepsy after deep cervical lymphovenous anastomosis in Alzheimer’s disease: a case report
Lymphovenous anastomosis (LVA) is emerging as a potential surgical intervention to ameliorate cervical lymphatic outflow and enhance glymphatic clearance in Alzheimer’s disease (AD). However, the spectrum of neurological sequelae associated with this procedure remains poorly characterized. We…
-
Artikel Jurnal
Global scale-free brain activity as a potential neural signature of visual information processing in aging
IntroductionConfluent evidence suggests that aging is associated with a reduction in the spectral slope of neural recordings. This phenomenon has been hypothesized to reflect an increase in the ratio of excitatory and inhibitory (E/I) balance. As neural E/I ratio is considered essential for…
-
Artikel Jurnal
Global research trends on thyroid hormones and neurodegenerative diseases: a bibliometric study from 2015 to 2025
ObjectiveDespite extensive research on the role of thyroid hormone (TH) in neurodegenerative diseases (NDs), no bibliometric study has been conducted to evaluate their interrelationship. To fill this gap, this study conducts an analysis of literature published between 2015 and 2025, aiming to…
-
Artikel Jurnal
Development and internal validation of a spatiotemporal gait parameter-based diagnostic model for cerebral small vessel disease
IntroductionCerebral small vessel disease (CSVD) is a common cause of functional decline in the elderly, yet its diagnosis often relies on neuroimaging, which may be inaccessible in routine practice. Given that gait impairment is a core feature of CSVD, we aimed to develop and validate a clinically…
-
Artikel Jurnal
Neuroanatomical patterns of dementia risk in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. While previous studies have reported a high prevalence of dementia diagnoses in the ASD population, the risk of dementia-related neurodegeneration remains poorly understood. This study aimed to assess dementia-sensitive composite…
-
Artikel Jurnal
Age differences in socio-emotional feedback processing during learning: an ERP study
In an ever-changing environment, the ability to adapt behavior based on feedback is a crucial skill. Although this process is assumed to decline with age, initial evidence suggests that emotional information processing may help buffer against these age-related impairments. We therefore conducted a…
-
Artikel Jurnal
Epilepsy and EEG abnormalities in neurodegenerative dementias: toward a system epilepsy framework
Epilepsy and epileptiform activity represent underrecognized yet clinically significant features of neurodegenerative dementias, with emerging evidence suggesting they may contribute to disease progression rather than merely representing epiphenomena of neuronal loss. This comprehensive review…
-
Artikel Jurnal
Gut microbiota and cognitive decline: a scoping review of microbial mechanisms and adaptive responses in dementia
Dementia is a progressive disease that results in a loss of mental capacity. Some of the most affected cognitive skills are memory, orientation, and language. These skills are also associated with behavioral shifts such as increased agitation and apathy, worsening the affected person’s quality of…
-
Artikel Jurnal
Autologous SVF therapy modulates neuroinflammation in ALS: phase I trial demonstrating safety and CSF biomarker dynamics
BackgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with limited treatments. Stromal vascular fraction (SVF), a cell population derived from autologous adipose tissue, exhibits multimodal immunomodulatory and neuroprotective properties, positioning it as a promising…
-
Artikel Jurnal
Chronic Kidney disease and cognitive frailty in aging: molecular crosstalk and clinical implications
BackgroundChronic kidney disease (CKD) and cognitive frailty frequently co-occur in older adults, compounding adverse health outcomes and placing substantial strain on healthcare systems.SummaryThis review outlines the molecular pathways that link CKD to cognitive decline, including chronic…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.