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Artikel Jurnal
Ketogenic interventions enhance REM sleep in females and support memory in aged rats
IntroductionSleep disruption and metabolic decline are key contributors to cognitive aging and dementia risk. While cerebral glucose utilization declines with age, ketone metabolism remains relatively preserved, suggesting that ketogenic interventions may enhance brain energetics, sleep quality…
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Artikel Jurnal
Risk score for futile recanalization: integrating cerebral circulation time and collateral cascade
IntroductionImpaired microvascular reperfusion despite successful recanalization may contribute to futile recanalization (FR) following thrombectomy. By combining cerebral circulation time (CCT) and cerebral collateral cascade (CCC) to evaluate hemodynamic and microcirculatory disturbances, we aim…
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Artikel Jurnal
Age-related degradation of behavioral and network features of Aplysia escape locomotion
IntroductionAplysia californica has been a useful model system for studies of the neural basis of behavior, learning, and aging. While the latter topic has been explored with respect to several of its simple reflex behaviors, this study represents the first examination of how one of Aplysia’s more…
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Pink1 at the crossroads of aging, exercise, and diet in Parkinson’s disease: a mechanistic review
Pink1 (PTEN-induced kinase 1) is a key guardian of mitochondrial quality via mitophagy; its mutations are tightly linked to early-onset PD. This review synthesizes how aging, exercise, and high-fat diet (HFD) modulate Pink1 activity and thereby PD risk. Aging down-regulates Pink1, impairing…
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The therapeutic efficacy of transcranial direct current stimulation in managing Alzheimer’s disease: a systematic review and meta-analysis
ObjectiveThe present study aimed to investigate the therapeutic efficacy of transcranial direct current stimulation (tDCS) for Alzheimer’s disease (AD) and identify potential influential factors.MethodsA comprehensive literature search was conducted in PubMed, Embase, Web of Science, and the…
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Artikel Jurnal
Research on Alzheimer’s disease MRI image classification based on spatial attention mechanism
IntroductionEarly diagnosis of Alzheimer’s Disease (AD) is crucial for improving patient quality of life and treatment outcomes. However, accurately classifying MRI scans of AD remains challenging due to the subtle and spatially complex nature of lesion regions. This study proposes a novel…
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Artikel Jurnal
Neuroprotective effects of isoflavone-enriched soybean leaves (Glycine Max) on scopolamine-induced memory deficits in C57BL/6 mice via antioxidative mechanisms
IntroductionThis study aimed to investigate the neuroprotective and memory-enhancing effects of isoflavone-enriched soybean leaves (IESLs) against scopolamine-induced cognitive impairment. While soybean leaves (SLs) are naturally rich in kaempferol glycosides and soyasaponins, IESLs are…
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Artikel Jurnal
Processing speed moderates the relationship between age and crystallized intelligence and influences the indirect effect of age on verbal working memory in middle-aged and older adults
This study examined the extent to which processing speed moderates the relationship between age and crystallized intelligence and influences the indirect effect of age on verbal working memory in 233 healthy middle and older adults aged 51–94 years. Participants were screened for cognitive…
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Robotic rehabilitation with the Lokomat® system in the improvement of executive functions and processing speed in stroke patients: a quasi-experimental study
ObjectiveTo evaluate the effects of robotic rehabilitation with the Lokomat® system on executive functions and processing speed in stroke patients.MethodsA quasi-experimental pretest-posttest study was conducted with a sample of 136 patients with a confirmed stroke diagnosis. Participants were…
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Artikel Jurnal
Near-infrared spectroscopy-based cerebral oxygen monitoring in perioperative neurocognitive disorders of older adults: current evidence and future perspectives
Perioperative neurocognitive disorders (PNDs) are common pathophysiological states and neurological complications in older adult patients after surgery, which severely restrict the quality of postoperative rehabilitation and increase the social medical burden. Cerebral oxygen saturation monitoring…
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Artikel Jurnal
Dysregulated glucose metabolism in the visual cortex of human subjects with mild cognitive impairment and Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is characterized by progressive neurodegeneration and impaired glucose metabolism. While most studies focus on heavily affected brain regions such as the hippocampus and prefrontal cortex, the visual cortex remains relatively preserved in early AD and provides…
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Artikel Jurnal
Short-term hearing aid use reduces auditory cortical responses to speech-in-noise listening among older adults with age-related hearing loss
Age-related hearing loss (ARHL) is an increasingly common feature of aging and has been linked to poorer psychosocial wellbeing and increased dementia risk. Individuals with ARHL experience speech perception difficulties in noisy environments, wherein the brain must “turn up the volume” or…
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Artikel Jurnal
Quantity and quality of care and staff knowledge regarding people with Parkinson’s disease in long-term nursing care: “real-life” results from the German Care4PD study
IntroductionApproximately 20% of people with Parkinson’s disease (PwP) in Germany need professional long-term care (LTC). Previous data have indicated a rather poor LTC situation and the need for more profound analyses. Therefore, we aimed to assess the quantity and quality of LTC care for PwP and…
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Artikel Jurnal
The alterations in brain network functional gradients and dynamic functional connectivity in Alzheimer’s disease: a resting-state fMRI study
Background and purposeAlzheimer’s disease (AD), the most common form of dementia worldwide, is characterized by progressive cognitive decline. Extensive evidence from dynamic functional connectivity (dFC) studies has demonstrated unstable functional states, reduced network flexibility, and impaired…
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Altered brain network dynamics and functional connectivity in subjective cognitive decline: an edge-centric network study
PurposeTo explore neurodynamic bases underlying subjective cognitive decline (SCD) based on edge-centric functional network.Methods211 SCD patients and 210 healthy controls (HC) were recruited from the Alzheimer’s Disease Neuroimaging Initiative. Edge time series (ETS) were obtained based on…
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Cortical activation and functional connectivity between healthy elderly and Parkinson’s disease patients and between cognitive subgroups of Parkinson’s patients: a multichannel functional near-infrared spectroscopy study
BackgroundThe rising global burden of Parkinson’s disease (PD) is often related to cognitive decline. Exploring neuroimaging biomarkers is crucial for early diagnosis.MethodsThe purpose of the exploratory research was to look at the differences in cortical activation and functional connectivity…
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LRP1 at the crossroads of Aβ clearance and therapeutic targeting in Alzheimer’s disease
Alzheimer’s disease (AD), characterized by progressive cognitive decline, memory impairment and behavioral disturbances, is the most common form of dementia, and no disease-modifying treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to play a pivotal role in…
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Artikel Jurnal
Exploring rare coding variants in UK biobank: preliminary associations with motor neuron disease
IntroductionPrevious studies have illuminated a significant genetic component in motor neuron disease (MND) pathogenesis, with several causative genes identified. However, a substantial proportion of MND cases remain genetically unexplained, particularly regarding the comprehensive contribution of…
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Artikel Jurnal
Mechanistic insights into the anti-neuroinflammatory effects of cassia obtusifolia in Parkinson’s disease: a network pharmacology-based study
BackgroundParkinson’s disease (PD) is a chronic neurodegenerative disorder that is closely associated with neuroinflammation, yet effective anti-inflammatory therapies remain limited. This study aimed to elucidate the potential mechanisms of Cassia obtusifolia in mitigating PD-associated…
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Artikel Jurnal
Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women
IntroductionWomen have a higher risk of developing Alzheimer’s disease (AD) than men, with hormonal changes during menopause being a potential factor. However, the exact relationship between these hormonal changes, cognitive function, and AD pathology is not fully understood. This study…
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