8.223 hasil
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Artikel Jurnal
Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants
BackgroundCognitive reserve (CR) may protect cognitive performance under pathology. Depressive symptoms are common in mid and late life and are linked to poorer cognition. This study investigated whether depressive symptoms mediate the association between CR and both global and domain-specific…
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Artikel Jurnal
AI agents in Alzheimer’s disease management: challenges and future directions
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease pose a major global healthcare challenge, with cases projected to rise sharply as populations age and effective treatments remain limited. AI has shown promise in supporting diagnostics, predicting disease progression, and…
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Artikel Jurnal
Factors associated with sleep disorders in elderly patients with Parkinson’s disease and cognitive impairment and the nomogram model development
BackgroundSleep disorders are a common complication in elderly patients with Parkinson’s disease and cognitive impairment. This retrospective cohort study investigates the factors associated with sleep disorders in elderly patients with Parkinson’s disease and cognitive impairment and proposes a…
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Artikel Jurnal
Machine learning models for the prediction of levodopa response to tremor in Parkinson’s disease
ObjectivesTo develop and validate machine learning models to predict levodopa responsiveness of tremor in Parkinson’s disease (PD) patients.MethodsA total of 197 PD tremor patients underwent Levodopa Challenge Tests and were classified as having levodopa-responsive or levodopa-resistant tremor…
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Artikel Jurnal
Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment
BackgroundReduced heart rate variability (HRV) has been associated with cognitive decline in older adults. However, prior research relied on brief in-clinic electrocardiography (ECG) recordings to measure HRV. Using 7-day continuous ambulatory ECG monitoring, we investigated time-specific…
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Artikel Jurnal
The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts
BackgroundEarlier research has documented an association between depressive symptomatology and heightened stroke risk. However, prior work largely assessed depressive manifestations at isolated time points and failed to differentiate symptom subtypes. This investigation seeks to characterize the…
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Artikel Jurnal
Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging
ObjectiveMicroglia are the primary immune cells in the central nervous system (CNS); however, their temporal and spatial responses to traumatic brain injury (TBI) at the single-cell level remain poorly defined. This study aimed to map the dynamic microglial responses to TBI using single-cell…
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Artikel Jurnal
A comprehensive evaluation of the associations between 12 composite inflammatory indices and all-cause mortality after stroke: a multicohort study
BackgroundInflammation plays a critical role in post-stroke mortality. However, identification of robust and generalizable inflammatory biomarkers for post-stroke mortality remains a challenge. We conducted a comprehensive analysis of various composite inflammatory indices, evaluating the…
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Artikel Jurnal
The top 100 cited articles on artificial intelligence in Alzheimer’s disease and mild cognitive impairment: a bibliometric analysis
BackgroundAlzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) pose significant societal and healthcare burden. Artificial intelligence (AI) methods have been widely applied in AD and MCI studies. We conducted a bibliometric analysis of the 100 most cited articles on AI applied to AD and…
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Artikel Jurnal
Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes
BackgroundMild cognitive impairment (MCI) is a cognitive decline syndrome in the elderly, often a precursor to dementia. It is a heterogeneous condition that can signal degenerative disorders like Alzheimer’s or non-degenerative conditions such as vascular issues, depression, or poorly managed…
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Artikel Jurnal
Separating cognitive and motor contributions to iADL difficulties in Parkinson’s disease
BackgroundMild Cognitive Impairment (MCI) and dementia are distinguished by whether cognitive deficits interfere with independent performance of instrumental activities of daily living (iADLs). In Parkinson’s disease (PD) this distinction is challenging due to the combined impact of motor and…
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Artikel Jurnal
Development and validation of a prognostic nomogram for predicting ventilator-associated pneumonia risk in elderly large vessel occlusion ischemic stroke after endovascular therapy patients
BackgroundAcute ischemic stroke with large vessel occlusion (AIS-LVO) poses a grave threat to the health of the elderly, exhibiting a high degree of disability and mortality. Post-stroke ventilator-associated pneumonia (VAP) significantly impairs neurological recovery and worsens clinical outcomes…
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Artikel Jurnal
Investigating age-related decline in sensorimotor control using robotic tasks
Aging is associated with changes in sensorimotor control that contribute to functional decline, mobility limitations, and increased fall risk. Traditional motor assessments often rely on subjective measures, highlighting the need for objective, quantitative tools. We developed three robot-based…
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Artikel Jurnal
A 24-week multi-component exercise program improves cognition and body composition in older adults with mild cognitive impairment: a randomized controlled trial
BackgroundThis study investigated whether a 24-week, community-based multicomponent exercise intervention (MCEI) can improve body composition and cognitive function in older adults with mild cognitive impairment (MCI).MethodsIn this single-center, parallel-group randomized controlled trial (RCT)…
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Artikel Jurnal
Rewiring the aging brain: exergaming modulates brain complexity in older adults
IntroductionAge-related changes in brain signal complexity are associated with cognitive decline and reduced neural adaptivity in older adults. Exergaming offers a promising prophylactic intervention combining physical and cognitive training. The aim of the present study was to assess how…
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Artikel Jurnal
Subclinical infection combined with surgery induced cognitive dysfunction: a novel adult mouse model for perioperative neurocognitive disorder
IntroductionPerioperative neurocognitive disorder (PND) describes a range of cognitive impairments associated with surgery and anaesthesia, often driven by neuroinflammation. This study explored a novel adult mouse model, in which preoperative subclinical infection, induced by low-dose…
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Artikel Jurnal
Association of psychosis with cognitive impairment is mediated by amyloidopathy in cognitive impairment
BackgroundPsychosis, including delusions and hallucinations, is a significant neuropsychiatric symptom in Alzheimer’s disease (AD) associated with poor prognosis. The relationship between psychosis and AD pathology remains controversial. This study investigates the role of AD pathology in mediating…
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Artikel Jurnal
Identification and validation of an interpretable EEG-based machine learning model for the diagnosis of post-stroke cognitive impairment
IntroductionPost-stroke cognitive impairment (PSCI) is a prevalent and disabling consequence of stroke, yet objective tools for its early identification are lacking. This study aimed to develop and validate an interpretable machine learning (ML) model based on electroencephalography (EEG) to…
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