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Artikel Jurnal
Apolipoprotein A1 reduces blood–spinal cord barrier leakage, improves astrocytic coverage, and enhances motor neuron survival to restore the neurovascular unit in ALS mice
IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive, age-related motor neuron degenerative disease with multiple causal factors. Dyslipidemia has been identified as an important pathological element. Impaired lipid protein metabolism manifests in ALS patients and in an ALS mouse model…
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Artikel Jurnal
Neural control of anticipatory braking and lateral balance predicts fall risk in older adults: BMI-dependent mechanisms
IntroductionFalls are a leading cause of disability among older adults, and neural control is increasingly recognized as a critical risk factor. In this prospective cohort study, we investigated whether deceleration during terminal swing (DCEL), and medial-lateral velocity zero crossing count…
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Artikel Jurnal
Beyond the auditory system: cognitive implications of age-related hearing loss
Age-related hearing loss (ARHL) is one of the most common causes of disability in older adults. It is also frequently associated with neurological and neurodegenerative disorders, including dementia, as well as with stress, anxiety, depression, and social isolation. These observations suggest that…
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Artikel Jurnal
Decreases in the sustained firing capacity of layer 2/3 pyramidal neurons in the anterior cingulate cortex of aged rats
The anterior cingulate cortex (ACC) is particularly vulnerable to aging, which impairs cognitive functions such as attention and working memory. Although aging is known to alter intrinsic electrophysiological properties in other brain regions, the differences in the properties of aged ACC neurons…
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Artikel Jurnal
Unraveling the anti-neuroinflammatory mechanisms of Cervus cucumis polypeptide injection in Alzheimer’s disease: insights from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation
ObjectiveAlzheimer’s disease (AD) is a progressive neurodegenerative disorder with increasing global prevalence, in which neuroinflammation serves as a critical pathological driver exacerbating cognitive decline. While current therapies offer limited symptomatic relief, multi-target strategies are…
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Artikel Jurnal
No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults
BackgroundHigh blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudied in groups who are at particularly high risk for dementia, such as Hispanic/Latino adults. Therefore, we aimed to investigate the…
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Artikel Jurnal
Anti-inflammatory and immunomodulatory therapies are associated with reduced risk of age-associated neurodegenerative diseases: impact of sex and treatment duration
IntroductionNeurodegenerative diseases (NDDs) including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and non-AD dementias share chronic neuroinflammatory mechanisms that contribute to neuronal injury and disease progression. While…
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Artikel Jurnal
Associations among structural brain alterations, respiratory symptoms and cognitive impairment in patients with chronic obstructive pulmonary disease-related subclinical cognitive vulnerability: a multimodal neuroimaging study
BackgroundChronic obstructive pulmonary disease (COPD) is a systemic condition that often results in cognitive impairment. Nevertheless, the central nervous system correlates of COPD-related cognitive decline are not well-defined, representing a critical knowledge gap. The present study aimed to…
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Artikel Jurnal
Intranasal administration of stem cells and their derivatives for neurological and respiratory disorders: a systematic review of human clinical trials
ObjectiveThis systematic review evaluates the safety, feasibility, tolerability, and efficacy outcomes of intranasally administered stem cells and their derivatives (MSCs, NSCs, secretome, and EVs) for the treatment of neurological and respiratory disorders.MethodsA literature search was conducted…
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Investigating hepatitis E virus seroprevalence in patients with Alzheimer’s disease
BackgroundHepatitis E virus (HEV) exposure has been linked to neurologic manifestations and dementia. This study aims to clarify a possible association between HEV and Alzheimer’s disease (AD).MethodsWe performed a single-center retrospective case–control study of 453 cognitively impaired adults…
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Artikel Jurnal
Food-chain spirochetes: a unified hypothesis for Parkinson’s disease and dementia risk
Parkinson’s disease (PD) and dementia have risen markedly in many regions. While aging, genetics, toxicants, and protein misfolding explain key aspects of pathology, they do not fully account for synchronized temporal trends or pronounced regional heterogeneity in recent increases. This hypothesis…
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Artikel Jurnal
Potential for distinguishing the parkinsonian subtype of multiple system atrophy from Parkinson’s disease: a three-dimensional gait analysis study
ObjectiveDistinguishing the parkinsonian subtype of multiple system atrophy (MSA-P) from Parkinson’s disease (PD) at an early stage was a challenge, and gait analysis based on wearable sensors offers a reliable method to quantify gait parameters. In this study, we used a three-dimensional gait…
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Artikel Jurnal
The role and mechanisms of AMPK in neurovascular unit injury in Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by dopaminergic neuron loss and α-synuclein aggregation. Increasing evidence indicates that blood-brain barrier (BBB) dysfunction in the neurovascular unit (NVU) is an early pathological event driving PD…
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Artikel Jurnal
Predicting time across age: comparing performance and neural dynamics of younger and older adults in a temporal prediction task
Temporal prediction is the ability to anticipate the likely time of occurrence of events and is important for adaptive behaviour in our everyday lives. Studies indicated that predictive aspects of environmental stimuli can be leveraged to reduce reaction times and enhance stimulus processing…
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Optical coherence tomography artefact burden predicts cognitive decline and incident dementia
IntroductionScalable, low-burden biomarkers for predicting cognitive decline remain needed. We hypothesised that OCT acquisition irregularities (commonly termed scan artefacts), which may reflect visuomotor and attentional instability during imaging, carry prognostic information for cognitive…
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Artikel Jurnal
Oligodendrocyte dysfunction in neurodegenerative diseases: pathological features, underlying mechanisms and therapeutic targeting
Oligodendrocyte lineage cells, consisting of mature oligodendrocytes (mOLs) and their progenitors (OPCs), sustain myelination and support axonal metabolic integrity in the mammalian central nervous system. In neurodegenerative disorders, functional deficits spanning impaired mOL homeostasis and…
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Artikel Jurnal
Computational evaluation of carnosic acid as a 4EY7 inhibitor for potential anti-Alzheimer therapy
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized in part by cholinergic dysfunction resulting from excessive acetylcholinesterase (AChE) activity. Although currently approved AChE inhibitors provide symptomatic relief, their clinical benefits remain modest and are…
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Artikel Jurnal
Intracisternal IGF-1 gene delivery attenuates early anxiety-like behavior but not dopaminergic neurodegeneration in a 6-OHDA rat model of parkinsonism
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, leading to a spectrum of motor and non-motor symptoms. In addition to the motor deficits serving as the primary criteria for diagnosis, mood and anxiety disorders also…
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