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Artikel Jurnal
18F-FDG PET/MR reveals specific brain metabolic features in Parkinson’s disease with frailty
BackgroundFrailty is significantly more prevalent in individuals with Parkinson’s disease (PD) than in general population, yet the underlying neuropathophysiological mechanisms remain poorly understood. This study aimed to characterize the clinical features and cerebral metabolic patterns of frail…
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Artikel Jurnal
An eye-tracking-based Stroop test: an efficient method for evaluating frontal lobe function
IntroductionAssessing attention and frontal lobe function is essential for diagnosing dementia. The Stroop test is widely used for these purposes, and its validity and reliability have been verified. Nevertheless, test-related burdens and procedural complexity have prevented their use as a…
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Artikel Jurnal
Listening for Alzheimer’s clues: machine learning analysis of multidomain speech features for cognitive impairment screening
IntroductionEarly detection of Alzheimer’s disease (AD) is critical for timely intervention, particularly during the mild cognitive impairment (MCI) stage. This study aimed to develop and evaluate a multidomain speech analysis framework to support cognitive screening, biomarker prediction within…
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Integrative bibliometric and transcriptomic analyses identify selenium-associated molecular signatures in the aging brain
Background and purposeThe aging brain is particularly sensitive to alterations in selenium status. Selenium deficiency has been associated with impaired neural function, cognitive decline, and increased vulnerability to neurodegeneration. However, the molecular mechanisms that link selenium biology…
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Functional autonomy, comorbidities and cognitive decline: a mediation analysis in neurocognitive disorders
BackgroundNeurocognitive Disorders (NCDs) represent a growing global health concern, significantly impacting both quality of life and healthcare systems. Emerging evidence suggests that functional autonomy, measured through Activities of Daily Living (ADL) and Instrumental Activities of Daily…
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Artikel Jurnal
Dopamine 2 receptor ablation from cholinergic neurons attenuates L-DOPA induced dyskinesias
IntroductionL-DOPA-induced dyskinesia (LID) formation requires prominent dopamine oscillations over hours, across years of treatment. Striatal cholinergic interneurons (CIN) have been implicated in both the facilitation and attenuation of LID, but how CIN sense and respond to striatal dopamine…
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Association between the triglyceride-glucose index and disease severity in non-diabetic Parkinson’s disease patients
BackgroundThe triglyceride-glucose (TyG) index is a well-established biomarker of insulin resistance (IR) in non-diabetic populations, serving as a reliable indicator of metabolic health across diverse demographic groups. However, to date, few studies have explored the association between IR—as…
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Systemic delivery of anti-sense oligonucleotide targeting α-synuclein for treatment in a mouse model of multiple system atrophy
IntroductionMultiple System Atrophy (MSA) is a rare, sporadic, age-related synucleinopathy characterized by Parkinson-like motor symptoms and ataxia. There is no therapy for MSA other than symptomatic treatment. MSA is characterized pathologically by glial cytoplasmic inclusions (GCI) of…
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The recent research progress on traditional Chinese medicine application in Parkinson's disease: a review
BackgroundParkinson's disease (PD) is a type of neurodegenerative diseases with the characterized by static tremors, bradykinesia, and muscle rigidity. This is mainly caused by the degradation and death of dopaminergic neurons in the substantia nigra, severely affects the health of the elderly no…
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The inflammation-fibrosis combined index as a predictor of prognosis in stroke patients undergoing mechanical thrombectomy
Background and purposeThis study evaluates the novel Inflammation-Fibrosis Combined Index (IFCI) for predicting 90-day functional outcomes post-MT.MethodsWe conducted a retrospective analysis of 548 consecutive acute ischemic stroke patients treated with MT. The IFCI was derived from the…
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Classification and prediction of Alzheimer’s disease stages and conversion from mild cognitive impairment based on multimodal data fusion
ObjectiveThis study aimed to develop multimodal prediction models based on real-world clinical data for classifying different stages of Alzheimer’s disease (AD) and for predicting the conversion from mild cognitive impairment (MCI) to AD.MethodsA single-center retrospective real-world cohort study…
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Biological brain aging, cognitive-motor decline and vascular risk: a multivariate imaging analysis of 40,579 individuals
IntroductionAge-related declines in cognitive and motor functions show highly variable trajectories. To better understand the underlying mechanisms, we investigated multivariate associative effects between modifiable vascular risk factors, biological brain aging, cognitive, and motor performance in…
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Cerebrovascular–CSF coupling measured by broadband near-infrared spectroscopy as a physiological marker of brain aging and Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is strongly associated with cerebrovascular dysfunction and impaired glymphatic clearance. These dysfunctions may precede, contribute to, and interact bidirectionally with AD pathology, highlighting the importance of identifying physiological markers for the…
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Association of the Naples prognostic score with Parkinson disease risk: a prospective cohort study
BackgroundThe Naples prognostic score (NPS), derived from routine inflammatory and nutritional biomarkers, reflects systemic immune–metabolic status. Its prospective association with Parkinson disease (PD) risk has not been well established.MethodsWe analyzed 317,035 UK Biobank participants…
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Artikel Jurnal
Profiles of digital disability among Chinese older adults and its association with cognitive function: a latent profile analysis
BackgroundThe relationship between digital disability patterns and cognitive function among older adults remains complex. This research investigates how different patterns of digital disability were associated with cognitive function, with particular attention to the moderating role of…
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Artikel Jurnal
Determinants of caregiver burden in advanced Parkinson’s disease: a multidimensional and sex-sensitive perspective
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder whose advanced stages (Hoehn & Yahr IV–V) place significant demands on informal caregivers, leading to multidimensional burden. Although functional and cognitive decline contribute to caregiver strain, the influence of…
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Evaluation of conductivity tensor image along the perivascular space in the brains of patients with cognitive impairments
BackgroundThe diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index has been proposed as an imaging marker of impaired perivascular water transport across the Alzheimer’s disease (AD) continuum. Whether a conductivity-based ALPS derived from conductivity tensor imaging…
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Limbic-predominant neuroimaging correlates of plasma p-Tau217 in preclinical and clinical Alzheimer’s disease
BackgroundPlasma phosphorylated tau at threonine 217 (p-Tau217) has emerged as a highly sensitive and specific blood-based biomarker for Alzheimer’s Disease (AD). However, its regional brain correlates with multimodal neuroimaging, beyond tau-PET, remain underexplored, particularly in early disease…
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