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Artikel Jurnal
Feasibility study of differentiating patients with levodopa-induced dyskinesia using cerebellar gray and white matter radiomics features from 3DT1WI images
BackgroundLevodopa therapy effectively treats Parkinson’s disease (PD) motor symptoms but causes Levodopa-Induced Dyskinesia (LID) in some patients long-term. Cerebellar changes exist in LID cases; however, radiomics models based on this region haven’t been evaluated for diagnostic use. We built…
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Artikel Jurnal
APOE ε4 as a predictor of cognitive decline and its interaction with hippocampal volume in Alzheimer’s disease
Background/IntroductionThe apolipoprotein E (APOE) ε4 allele is the strongest known genetic risk factor for late-onset Alzheimer’s disease, and hippocampal atrophy is among the most reliable structural biomarkers of neurodegeneration. While both are independently associated with cognitive decline…
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Integrated transcriptomic profiling combined with in vitro validation reveals the involvement of TMEM140 in the link between periodontitis and brain aging
ObjectivePeriodontitis (PD) is a prevalent chronic inflammatory disorder in adults, and moderate-to-severe PD (Stage II-III/IV) may accelerate brain aging and neurodegenerative changes via the peripheral-central immune-neural axis, although the molecular connections and mechanisms of interaction…
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Secretory form of viral protease NIa ameliorates amyloid-β pathology and cognitive deficits in a mouse model of Alzheimer’s disease
Alzheimer’s disease (AD), the leading cause of dementia, is characterized by extracellular amyloid-β (Aβ) accumulation. Immunotherapies targeting Aβ clearance show promise, highlighting the therapeutic value of enhancing Aβ removal. We previously identified that nuclear inclusion a (NIa), a plant…
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Artikel Jurnal
Modulating the default mode network with deep TMS: a proof-of-concept framework with potential relevance to circuits implicated in lack of awareness of cognitive decline
IntroductionSelf-referential processes are suspected to rely on the default mode network (DMN), particularly the posterior cingulate cortex (PCC). The right PCC, has been implicated in self-awareness, with neuroimaging studies showing its involvement in anosognosia in Alzheimer’s disease. However…
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Artikel Jurnal
Ketogenic metabolic therapy: low-carbohydrate interventions as novel neuroprotective strategies for cognitive dysfunction in diabetes
Cognitive dysfunction is an increasingly recognized complication of diabetes, contributing substantially to morbidity in the aging population, yet disease-modifying therapies remain scarce. Dietary intervention, a cornerstone of diabetes management, may offer neuroprotective potential…
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Artikel Jurnal
Integrating acoustic, prosodic, and phonological features for automatic Alzheimer’s detection
IntroductionEarly and accurate diagnosis of Alzheimer’s disease (AD) is critical for effective intervention. While prior research has explored speech-based biomarkers for AD, the role of acoustic, prosodic, and phonological features, individually and in combination, remains…
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Artikel Jurnal
Toward future diagnostics of Parkinson's disease: a perspective on multimodal motor assessment and personalized digital twins
The accurate diagnosis of Parkinson's disease (PD) remains challenging due to the heterogeneity of motor symptoms and the reliance on subjective clinical assessments. Although biomarkers such as dopaminergic imaging, fluid assays, and genetic testing can support diagnosis, their clinical utility is…
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Artikel Jurnal
ALDH1A1-dopaminergic gene co-expression in human substantia nigra: meta-analysis of disease-associated correlation changes across seven independent Parkinson’s disease datasets
BackgroundParkinson’s disease (PD) involves progressive dopaminergic neuron loss in the substantia nigra (SN). Aldehyde dehydrogenase 1A1 (ALDH1A1), the rate-limiting enzyme in retinoic acid biosynthesis, is enriched in vulnerable dopaminergic neuron subpopulations and is consistently downregulated…
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Artikel Jurnal
Cognitive decline and reduced bone mineral density under the bone-brain axis: mechanistic insights and imaging evaluation strategies
Against the backdrop of an accelerating global aging population, the epidemiological correlation between cognitive impairment and osteoporosis has become increasingly prominent. These two conditions exhibit a profound pathological coupling mediated by the bidirectional regulatory network of the…
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Artikel Jurnal
Transcranial magnetic stimulation from healthy brain aging to Alzheimer’s disease: a review on mechanisms, therapeutic potential, and future clinical directions
Transcranial magnetic stimulation (TMS), a non-invasive and non-pharmacological intervention, is increasingly being explored for mitigating age-related cognitive decline and dementia. Its therapeutic potential is largely attributed to its capacity to modulate neuronal firing rates and induce…
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Artikel Jurnal
Route efficiency in spatial navigation as an early indicator of cognitive decline in amnestic mild cognitive impairment
IntroductionThe hippocampus is one of the brain regions most affected by neurodegeneration in Alzheimer’s disease (AD). This structure and its neural circuits are critically involved in spatial learning and memory. Poor spatial navigation performance in virtual environments such as the Virtual…
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Aging modulates amyloid clearance kinetics during anti-amyloid therapy: evidence from real-world serial amyloid PET
BackgroundAnti-amyloid antibodies have been shown to reduce cerebral amyloid burden in early Alzheimer’s disease (AD), yet considerable interindividual variability in treatment-associated amyloid reduction has been observed. The biological factors underlying this variability remain unclear. In…
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Artikel Jurnal
Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP, and NfL with cognitive impairment in Parkinson’s disease
BackgroundCognitive impairment is a major determinant of disability in Parkinson’s disease (PD), underscoring the need for biomarkers that reflect its underlying pathophysiology. Plasma biomarkers, including phosphorylated tau at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), and…
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Artikel Jurnal
Shaping the cognitive reserve: the role of lifelong enrichment and education in the Alzheimer’s disease continuum
BackgroundLeisure activities (LAs) are recognized as major contributors to cognitive reserve (CR), potentially mitigating age-related cognitive decline and dementia progression. However, the specific associations between lifelong engagement in different types of LAs, education (as a proxy of CR)…
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Artikel Jurnal
Reliability and validity of the balance recovery confidence scale in persons with stroke
BackgroundBalance recovery confidence represents a salient psychological factor influencing fall risk and functional mobility. The perceived ability to regain balance following a destabilising event may vary substantially among individuals. The Balance Recovery Confidence (BRC) Scale was developed…
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Nuclear accumulation of PANK4 in hippocampal astrocytes aggravates cuproptosis in association with mild cognitive impairment in aged mice
BackgroundMild cognitive impairment (MCI), a condition that falls somewhere between normal aging and severe cognitive dysfunction (e.g., Alzheimer’s disease), is a common manifestation of the neurocognitive function decline that seniors encounter as they age. The fundamental processes causing its…
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Efficacy of repeated external cueing training on freezing of gait and gait performance in Parkinson’s disease: a systematic review and meta-analysis
BackgroundFreezing of gait (FOG) is a disabling gait disturbance in Parkinson’s disease (PD) that responds poorly to pharmacological treatment. External cueing has been proposed as a non-pharmacological strategy to improve gait and mobility; however, the effectiveness of repeated external cueing…
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Artikel Jurnal
From muscle to brain: the mediating effect of vitamin D in the relationship between muscle loss and cognitive function in Alzheimer’s disease
ObjectiveTo investigate the association among Vitamin D (VD), muscle loss and cognitive function, and further analyze the possible role of VD in the association between muscle loss and cognitive function in patients with Alzheimer’s disease (AD).MethodsThis cross-sectional study included 58…
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Artikel Jurnal
Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson’s disease
IntroductionParkinson’s disease (PD) is characterized by progressive dopaminergic neurodegeneration, neuroinflammation, and emerging evidence of gut microbiota dysbiosis. Although nicotine has been implicated in neuroprotection, whether its enantiomers exert stereoselective effects on the gut-brain…
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