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Artikel Jurnal
Effects of Baduanjin exercise on working memory in mild cognitive impairment: an fNIRS-based randomized controlled trial
ObjectiveThis study utilized functional near-infrared spectroscopy (fNIRS) technology to investigate the effects of Baduanjin exercise on activation levels in the dorsolateral prefrontal cortex (DLPFC), frontal eye field (FEF), and somatosensory cortex (SSC) during working memory tasks in patients…
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Artikel Jurnal
Comparative risk of dementia between direct oral anticoagulants and warfarin after atrial fibrillation related ischemic stroke
IntroductionDirect oral anticoagulants (DOAC) have been associated with a reduced risk of dementia compared to warfarin in patients with atrial fibrillation (AF) without prior stroke. However, the impact of DOAC on dementia risk in AF-related ischemic stroke survivors is unclear.MethodsWe conducted…
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Artikel Jurnal
Research hotspots and trends in electrical stimulation for movement disorders: a bibliometric analysis from 2016 to 2025
Electrical stimulation therapies have become pivotal interventions for managing refractory movement disorders. However, the rapidly expanding and fragmented body of literature necessitates a macroscopic evaluation to identify global collaborative networks and emerging scientific frontiers…
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Artikel Jurnal
Beyond grip strength: selective slowing of grip force release but not initiation dynamics in a go/no-go target force–matching task
IntroductionPrecise regulation of grip forces is fundamental for skilled object manipulation and independent navigation of everyday activities throughout the lifespan. Maximal grip strength is a widely used biomarker of aging and frailty, but it provides limited insight into the temporal and…
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Artikel Jurnal
Klotho deficiency and cognitive impairment in dialysis patients: mechanisms, clinical evidence, and therapeutic implications
Cognitive impairment is highly prevalent among patients with end-stage renal disease (ESRD), particularly those undergoing dialysis, and is associated with poor clinical outcomes and reduced quality of life. Emerging evidence suggests that Klotho, an anti-aging protein predominantly expressed in…
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Artikel Jurnal
Depressive symptoms and multiple markers of brain aging in community-dwelling older adults
Late-life depressive symptoms have been associated with structural brain changes and cognitive impairment, but prior studies have typically examined individual markers of brain aging in isolation. This study examined the associations between depressive symptoms and multiple markers of brain aging…
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Artikel Jurnal
Exercise and neural circuit stability in early Alzheimer’s disease: evidence across memory, executive, cholinergic, and circadian systems
Early Alzheimer’s disease (AD) is increasingly understood as a phase in which neural circuit dysfunction emerges alongside molecular pathology and local neuronal injury. Although physical exercise has been linked to a deceleration in cognitive decline and beneficial cognitive and neural outcomes…
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Peripheral metabolomic profiling reveals lipid and amino acid alterations associated with immuno-inflammatory responses in treatment-naïve late-onset Alzheimer’s disease
BackgroundImmuno-metabolic dysregulation contributes to Alzheimer’s disease (AD) pathogenesis, yet the peripheral metabolic landscape and its interplay with neuroinflammation remain poorly characterized in treatment-naïve, late-stage patients. This study aimed to delineate plasma metabolic…
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Artikel Jurnal
Interpretable machine learning models for identifying cognitive impairment in middle-aged and older adults with mild and severe insomnia: development, temporal validation, and clinical external validation
BackgroundCognitive impairment is an important health issue in middle-aged and older adults, and insomnia may be associated with increased cognitive vulnerability. However, models specifically designed to identify cognitive impairment in individuals with different severities of…
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Artikel Jurnal
Aerobic exercise interventions for older adults with cognitive frailty: a systematic review
ObjectiveThe purpose of this study was to systematically review the effects of aerobic exercise on cognitive function in older adults using randomized controlled trials (RCTs).DesignThis study was a systematic review.Data sourcesTen databases, namely PubMed, the Cochrane Library, Wanfang, China…
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Artikel Jurnal
Association of the C-reactive protein-albumin-lymphocyte index with clinical outcomes after mechanical thrombectomy for acute ischemic stroke
ObjectiveThis study aims to explore the associations of C-reactive protein-albumin-lymphocyte (CALLY) index with hemorrhagic transformation (HT), malignant cerebral edema (MCE), and 90-day unfavorable outcome and all-cause mortality in patients with acute ischemic stroke (AIS) following mechanical…
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Artikel Jurnal
Integrating network pharmacology and experimental validation strategies to investigate the mechanisms and key flavonoids in medicinal and edible citrus plants against Alzheimer’s disease
IntroductionDue to the complexity of the Alzheimer’s disease (AD) pathophysiological processes, there is currently a lack of effective therapeutic drugs. The medicinal and edible substances have multiple advantages in treating AD, but their specific components and mechanisms remain unclear. This…
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Artikel Jurnal
Resting-state EEG microstates link neural dynamics to fluid intelligence in mild cognitive impairment
BackgroundResting-state EEG microstates offer millisecond-scale markers of large-scale network dynamics that may capture early cognitive dysfunction in Mild Cognitive Impairment (MCI). We investigated whether microstate characteristics relate to global cognition and fluid intelligence in…
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Artikel Jurnal
Older adult solitary drinking: associations with subjective and objective cognitive functioning
BackgroundSolitary drinking is a pattern of hazardous alcohol consumption that is problematic at any age but is more prevalent in older adults, yet most research focuses on younger samples. Research on solitary drinking and cognition is critical as older adults are more vulnerable to cognitive…
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Artikel Jurnal
Impact of obstructive sleep apnea on gut microbiome of patients with symptomatic intracranial atherosclerotic stenosis
IntroductionObstructive sleep apnea syndrome (OSAS) is positively associated with increased risks of ischemic stroke. Patients with stroke exhibit remarkable gut microbiota dysbiosis. However, the impact of OSAS on gut microbiota of patients with symptomatic intracranial atherosclerotic stenosis…
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Artikel Jurnal
Multimodal imaging and machine learning for diagnosis of Parkinson’s disease with cognitive impairment: ASL and QSM as potential biomarkers
Objectives: This study aimed to investigate differences in brain imaging characteristics among patients with Parkinson’s disease with cognitive impairment (PDCI), Parkinson’s disease without cognitive impairment (PDNCI), and healthy controls (HC), and to develop machine learning–based models for…
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Artikel Jurnal
Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders
BackgroundCognitive dysfunction affects over 50 million individuals worldwide, with Alzheimer’s disease (AD) representing two-thirds of cases. We identified CTHRC1 (Collagen Triple Helix Repeat Containing 1) as a novel candidate associated with cognitive function and neurodegeneration.MethodsHuman…
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Artikel Jurnal
Molecular pathways in vascular cognitive impairment and dementia: focus on synaptic plasticity and epigenetic modifications
BackgroundVascular cognitive impairment (VCI) is a group of cognitive disorders caused by cerebrovascular disease and is the second leading cause of dementia. VCI prevalence has significantly increased over the past decade. However, the molecular mechanisms underlying VCI remain…
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Artikel Jurnal
Oxytocin reduces anger bias, harm-intention recognition, and self-focus in behavioral variant frontotemporal dementia: a randomized double-blind placebo-controlled crossover trial
ObjectiveTo explore the effects of oxytocin administration on social cognition and social engagement in patients with behavioral variant frontotemporal dementia.MethodsIn a within-subject, double-blind, placebo-controlled, randomized crossover trial, patients with behavioral variant frontotemporal…
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