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Artikel Jurnal
Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson’s disease: a network meta-analysis of randomized controlled trials
ObjectiveTo systematically compare and rank the relative efficacy of different types of deep brain stimulation (DBS) for gait disorders in patients with Parkinson’s disease (PD), with particular emphasis on three outcomes: motor function (MDS-UPDRS III), Freezing of Gait Questionnaire (FOG-Q), and…
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Artikel Jurnal
The effects of video games on cognitive function in older adults with mild cognitive impairment: a meta-analysis
ObjectiveThis study aimed to evaluate the efficacy of video-game–based interventions in enhancing global cognitive function and executive functioning among individuals with mild cognitive impairment (MCI).MethodsA systematic search was conducted across PubMed, Web of Science, The Cochrane Library…
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Artikel Jurnal
Advances in the multifunctional roles of CX3CL1 in the central nervous system
C-X3-C motif chemokine ligand 1 (CX3CL1), a structurally unique chemokine in the central nervous system (CNS), shapes physiological and pathological processes via specific binding to its receptor, C-X3-C motif chemokine receptor 1 (CX3CR1). Empirical evidence indicates that this signaling axis…
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Artikel Jurnal
Combining plasma biomarkers, clinical parameters, and neuroimaging features for differential diagnosis of Parkinson’s disease and atypical parkinsonian syndromes: a multidimensional modeling approach
BackgroundThe early differential diagnosis of Parkinson’s disease (PD) and atypical parkinsonian syndromes (APSs) poses challenges. The current methods, which rely on clinical assessments and single-modal biomarkers, lack sufficient sensitivity and specificity. This study aims to develop a…
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Artikel Jurnal
The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: a systematic review and meta-analysis
ObjectiveThe number of people with dementia and cognitive impairment is rising every year as the older population grows. The higher prevalence and mortality rates of dementia and cognitive impairment place an enormous burden on healthcare and economic systems worldwide. Studies have shown that…
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Artikel Jurnal
After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency
AimStudies indicate that semantic fluency improved after cochlear implantation (CI) in older adults, but not in young and middle-aged adults. We were interested in identifying cognitive variables that are associated with this improvement. We tested whether improvements in cognition after cochlear…
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Artikel Jurnal
Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by β-amyloid (Aβ) deposition, tau protein hyperphosphorylation, and synaptic dysfunction. In recent years, 40 Hz sensory stimulation—including visual, auditory, and multimodal modalities—has emerged as a novel…
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Artikel Jurnal
A cross-database bibliometric analysis of rapid eye movement sleep behavior disorder in Parkinson’s disease research
BackgroundRapid eye movement sleep behavior disorder (RBD) is increasingly recognized as both a prodromal marker and a significant predictor of Parkinson’s disease (PD) progression. Despite a surge in related research, a comprehensive bibliometric evaluation summarizing the field’s development, key…
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Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software
Alzheimer’s disease (AD) is characterized by the accumulation of misfolded proteins that trigger neuroinflammation and neuronal loss. The retina, as an extension of the central nervous system, mirrors these pathological processes and represents a potential biomarker. Microglial activation, a key…
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Artikel Jurnal
Effect of deep brain stimulation on dysphagia in Parkinson’s disease: mechanisms, evidence, and outlook
IntroductionOropharyngeal dysphagia (OD) is a common and significant complication of Parkinson’s disease (PD), contributing to malnutrition, respiratory complications and impaired medication intake. The pathophysiology of OD in PD is heterogeneous, involving basal ganglia dysfunction with…
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Artikel Jurnal
Polarity-dependent modulation of sleep oscillations and cortical excitability in aging
BackgroundDuring non-rapid eye movement (NREM) sleep, cortical slow oscillation (SO; <1 Hz) and thalamic sleep spindle activity (12–15 Hz) interact through precise phase coupling to support memory consolidation. Slow oscillatory transcranial direct current stimulation (so-tDCS) can modulate these…
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Artikel Jurnal
Cardiorespiratory fitness does not predict longitudinal changes in manual dexterity, cognition or corticospinal excitability in multiple sclerosis
IntroductionNeurodegeneration in multiple sclerosis leads to progressive cognitive and motor impairments. Cardiorespiratory fitness (CRF) is thought to protect against such decline, but its longitudinal effects remain unclear. This study examined whether CRF predicts changes in behavioral (i.e…
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Electroacupuncture alleviates Parkinson’s disease by targeting HDAC/SIRT-mediated deacetylation of 14-3-3
IntroductionParkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of pathological α-synuclein. Although current treatments can alleviate symptoms, they do not modify disease progression. Growing evidence implicates gut…
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Artikel Jurnal
The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss
ObjectivesThis study aimed to characterize serum exosomal miRNA profiles from patients with age-related hearing loss (ARHL) to identify key pathogenesis-related miRNAs for ARHL.MethodsPeripheral venous blood samples were collected from patients with ARHL and elderly controls, and exosomes were…
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Artikel Jurnal
The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease
BackgroundMitochondrial dysfunction and protein aggregation are central features of brain aging and Alzheimer’s disease (AD). To define how AD seed proteins modulate these processes, we applied quantitative proteomics to sarkosyl-insoluble aggregates from C. elegans models of normal aging and from…
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The olfactory functional network in the Alzheimer’s disease continuum: a resting state fMRI study
IntroductionOlfactory dysfunction is common in the Alzheimer’s Disease continuum, and olfaction may be altered before clinical syndrome onset. The present study aimed at investigating the functional connectivity of the olfactory cortex and its correlation with olfaction performance in a group of…
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Artikel Jurnal
Correlation between blood biomarkers and post-stroke cognitive impairment
BackgroundPost-stroke cognitive impairment (PSCI) is common and imposes a significant burden upon both families and society. There is limited information on biomarkers for PSCI. This study investigated the correlation between blood biomarkers and post-ischaemic stroke cognitive impairment, to…
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Influence of anesthetic agent and burst suppression on postoperative delirium in elderly patients: a prospective cohort study with automated EEG analysis
BackgroundGuidelines currently suggest considering EEG guidance during general anesthesia in elderly patients to avoid prolonged burst suppression (BS), with the aim of mitigating postoperative delirium (POD). Our study aimed to investigate the association between POD and intraoperative BS duration…
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Artikel Jurnal
Machine learning-guided analysis of metabolomic alterations in Parkinson’s disease with comorbid symptoms
IntroductionAs a common neurodegenerative disorder, Parkinson’s disease (PD) primarily affects dopaminergic neurons, leading to progressive motor disabilities along with a spectrum of non-motor complications. The early identification of Parkinson’s disease, as well as the exploration of biomarkers…
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Artikel Jurnal
Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024
ObjectiveAstrocytes, constituting the predominant glial cell population with in the central nervous system, have emerged as a focal point of investigation due to their multifaceted roles and therapeutic implications in cognitive disorders. Despite the growing body of research, there has yet to be a…
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