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Artikel Jurnal
Icaritin ameliorates mitochondrial dysfunction and autophagy impairment in cellular models of Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is the most common form of dementia, characterized by progressive memory decline, with neuropathological hallmarks including amyloid plaques and neurofibrillary tangles. Current treatments only alleviate symptoms and cannot halt disease progression. Icaritin…
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Artikel Jurnal
Meta-analysis reveals apolipoprotein ε4 confers higher susceptibility to Parkinson’s disease dementia in Asian populations
Multiple studies show conflicting association between APOE polymorphisms and the risk of PDD, yielding inconsistent results. To elucidate, a meta-analysis was conducted using existing articles from Web of Science, PubMed, Cochrane, Google Scholar, Embase, WanFang, and CNKI databases, including…
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Artikel Jurnal
Machine learning analysis of population-wide plasma proteins identifies hormonal biomarkers of Parkinson’s disease
With the number of Parkinson’s patients expected to rise due to an aging population, there is an increasing need to identify new diagnostic markers. These markers should be affordable and suitable for routine use to monitor the population, help stratify patients for treatment pathways, and provide…
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Artikel Jurnal
Choline alphoscerate: insights between acquired certainties and future perspectives
While mild cognitive impairment (MCI) is a risk factor for dementia, it is currently impossible to predict which patients will go on to develop dementia or Alzheimer’s disease. Given the projected global increase in dementia due to an increasingly aging population, there is an urgent need to…
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Artikel Jurnal
Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment——evidence from EEG
ObjectiveThis study investigates the interplay between muscle strength, information processing speed, EEG-specific biomarkers, and cognitive function in elderly individuals with cognitive impairments, emphasizing the mediating roles of information processing speed and EEG-specific…
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Artikel Jurnal
Functional and effective EEG connectivity patterns in Alzheimer’s disease and mild cognitive impairment: a systematic review
BackgroundAlzheimer’s disease (AD) might be best conceptualized as a disconnection syndrome, such that symptoms may be largely attributable to disrupted communication between brain regions, rather than to deterioration within discrete systems. EEG is uniquely capable of directly and non-invasively…
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Artikel Jurnal
Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma
IntroductionAlzheimer’s disease (AD) and glioblastoma (GBM) are severe neurological disorders that pose significant global healthcare challenges. Despite extensive research, the molecular mechanisms, particularly those involving mitochondrial dysfunction, remain poorly understood. A major…
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Artikel Jurnal
Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease
ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative…
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Artikel Jurnal
Improved early postoperative cognition in elderly gastrointestinal patients: a randomized controlled trial on the role of ultrasound-guided stellate ganglion block
BackgroundThis study evaluates the impact of ultrasound-guided stellate ganglion block (SGB) on early postoperative cognitive dysfunction (POCD) in elderly patients who underwent laparoscopic gastrointestinal (GI) surgery, as well as its potential effect on oxidative stress and inflammatory…
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Artikel Jurnal
Relationships of hematocrit concentration with dementia from a multiethnic population-based study
ObjectiveRed blood cell (RBC) concentration impacts cerebrovascular disease, yet it is unclear whether RBC concentrations relate to dementia risk, particularly in racially/ethnically diverse cohorts. We investigated whether RBC concentrations associate with incident dementia risk in a diverse…
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Artikel Jurnal
Identification of Parkinson’s disease using MRI and genetic data from the PPMI cohort: an improved machine learning fusion approach
ObjectiveThis study aim to leverage advanced machine learning techniques to develop and validate novel MRI imaging features and single nucleotide polymorphism (SNP) gene data fusion methodologies to enhance the early identification and diagnosis of Parkinson’s disease (PD).MethodsWe leveraged a…
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Artikel Jurnal
MicroRNAs signatures as potential molecular markers in mild cognitive impairment: a meta-analysis
Mild cognitive impairment (MCI) is characterized by a decline in cognitive functioning without significant interference in daily activities. Its high heterogeneity and elevated conversion rate to dementia pose challenges for accurate diagnosis and monitoring, highlighting the urgent need to…
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Artikel Jurnal
The role of vitamin K2 in cognitive impairment: linking vascular health to brain health
Cognitive impairment, marked by a decline in essential mental aspects such as attention, memory, and problem-solving, is significantly correlated with advancing age. This condition presents a major challenge for the elderly, adversely affecting quality of life, diminishing independence, and…
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Artikel Jurnal
Abnormal resting-state EEG neural oscillations and functional connectivity in mild cognitive impairment
BackgroundMild cognitive impairment (MCI) exhibits abnormal resting-state EEG oscillations in delta (1–4 Hz), theta (4–7 Hz), and alpha (8–13 Hz) bands, though findings remain inconsistent. Moreover, dynamic functional connectivity (FC) alterations in these bands are poorly understood. To address…
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Artikel Jurnal
Latent profiles and correlates factors of cognitive function in older adults: a cross-sectional study
ObjectiveThis study aimed to identify the latent profiles of cognitive function among community-dwelling and institutionalized older adults, and to examine their associated influencing factors, in order to inform the development of targeted interventions.MethodsA convenience sampling method was…
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Artikel Jurnal
Unveiling the glymphatic system’s impact on neurodegenerative diseases: a comprehensive bibliometric analysis (2012–2024)
BackgroundThe glymphatic system is a crucial factor in the development of neurodegenerative diseases (NDs) and holds substantial promise for therapeutic strategies. However, despite its growing significance, detailed bibliometric investigations specifically targeting the interplay between the…
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Artikel Jurnal
A 15-year bibliometric analysis of body mass index moderation in the management of Parkinson’s disease
ObjectiveParkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterized by worsening motor symptoms, that significantly impair patients’ activities of daily living and quality of life. Emerging evidence indicates a correlation between body mass index (BMI) and PD…
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Artikel Jurnal
Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study
ObjectivePeritoneal dialysis (PD) patients demonstrate distinct iron homeostasis imbalances. However, the relationship between brain iron and cognitive impairment in this population remains poorly elucidated.MethodsThis study enrolled 52 PD patients and 49 healthy controls (HCs). Quantitative…
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Artikel Jurnal
Music elicits different gene expression responses in the buccal cavity of age-related cognitive disorders patients and healthy controls
IntroductionRecent evidence suggests that external stimuli can shape transcriptomes, a field emerging as sensogenomics. Specifically, the analysis of capillary blood samples has shown that musical stimuli can modulate gene expression patterns, not only in healthy individuals but also in those with…
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