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Artikel Jurnal
Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers
IntroductionThe apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and cardiovascular disease. This study aimed to investigate the interactive effects of APOE ε4 genotype and cardiovascular risk on the microstructure of the nucleus basalis…
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Artikel Jurnal
Excessive daytime sleepiness and gait disturbances in patients with Parkinson’s disease
BackgroundExcessive daytime sleepiness (EDS), which is common in Parkinson’s disease (PD), has been reported to exacerbate gait disturbance in patients with PD, but there is a lack of objective assessment, as well as an unknown specific mechanism. The purpose of our study is to explore the…
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Artikel Jurnal
Microglia-associated research in Parkinson’s disease: a bibliometric analysis
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder that predominantly affects the elderly. Evidence indicates that microglia-mediated neuroinflammation is recognized as one of the key mechanisms in PD. This study aims to analyze the key points, hotspots, and emerging frontiers in…
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Artikel Jurnal
MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress
BackgroundParkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and its exact pathogenesis remains unclear. This study aims to comprehensively explore the role of MFN2 in PD based on in vivo and in vitro models for multidimensional understanding.MethodsIn vivo…
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Artikel Jurnal
Effects of exercise-cognitive dual-task training on cognitive frailty in older adults: a randomized controlled trial
ObjectiveThis study aims to investigate the effects of exercise-cognitive dual-task training on frailty status, cognitive function, physical performance, and dual-task cognitive load in older adults with Cognitive frailty (CF) over a 16-week intervention period.MethodsThis randomized controlled…
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Artikel Jurnal
Exercise-mediated cerebrovascular repair in Alzheimer's disease: from pathophysiology to therapeutic precision
Cerebrovascular dysfunctions, encompassing changes in cerebrovascular microstructure, blood-brain barrier (BBB) integrity, cerebrovascular reactivity, and cerebral blood flow (CBF), accelerate the pathological progression of Alzheimer's disease (AD). Exercise emerges as a promising…
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Artikel Jurnal
Cerebral amyloid angiopathy: a narrative review
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the accumulation of amyloid-beta (Aβ) in the walls of cerebral vessels. It is commonly associated with cognitive decline, cerebral hemorrhage, and other neurological pathologies. Despite its prevalence and impact…
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Artikel Jurnal
Functional Cognitive Disorder: diagnostic challenges, clinical features, and future directions in a misunderstood condition
Functional Cognitive Disorder (FCD), a condition marked by significant subjective cognitive complaints in the absence of identifiable neurological disease, is increasingly recognized as a distinct and underdiagnosed entity in clinical practice. This review synthesizes recent findings to clarify its…
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Artikel Jurnal
The interaction between resilience framework and neuron-astrocyte-synapse dynamics in AD
The concept of resilience can be used to explain why there are differences in the degree to which the brain functions of different individuals are impaired due to aging and pathological factors associated with neurodegenerative diseases. It encompasses cognitive reserve, brain reserve, and brain…
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Artikel Jurnal
Empathy in mild cognitive impairment: a preliminary clinical comparative study in Southern Switzerland using the interpersonal reactivity index (IRI) and the story-based empathy task (SET)
IntroductionMild Cognitive Impairment (MCI) is a transitional stage between normal aging and dementia, frequently associated with subtle deficits in social cognition. Empathy, a core component of social cognition, encompasses both affective and cognitive dimensions and may be compromised even in…
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Artikel Jurnal
Comparative efficacy of deep transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation in improving lower extremity motor function in subacute stroke patients
BackgroundDeep transcranial magnetic stimulation (dTMS) is more beneficial in activating the leg muscle cortical representation. However, to date, no studies have evaluated the advantages of dTMS compared to repetitive transcranial magnetic stimulation (rTMS) in improving lower extremity motor…
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Artikel Jurnal
Cognitive performance, sleep quality and physical activity as predictors of functional mobility in older adults
ObjectiveThis study investigated the relationships between functional mobility and cognitive performance, sleep quality and physical activity in older adults according to age, sex, weight status and education, and whether these variables could be predictors of functional mobility and fall…
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Artikel Jurnal
Mapping the research landscape of Mild Cognitive Impairment in Parkinson’s disease: a bibliometric and visualization analysis
BackgroundMild Cognitive Impairment in Parkinson’s disease, a common non-motor symptom of Parkinson’s disease, significantly impacts individuals’ quality of life and predicts dementia risk, underscoring its clinical research importance. This study aimed to characterize the global bibliometric…
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Artikel Jurnal
Subcutaneous foslevodopa/foscarbidopa initiation in a Parkinson’s day-clinic - a suitable setting to ensure treatment efficacy, tolerability and psychosocial adaption
BackgroundSubcutaneous foslevodopa/foscarbidopa (LDp/CDp) has expanded the treatment options in advanced Parkinson’s disease (aPD). However, the most appropriate therapeutic setting for therapy implementation is not clear.ObjectiveTo present a concept for LDp/CDp therapy implementation in a…
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Artikel Jurnal
Parkinson’s disease beyond the brain: implications for treatments
The presence of α-synuclein pathology in peripheral nervous system neurons is linked to early prodromal, non-motor symptoms in a segment of Parkinson’s disease (PD) patients referred to as “body-first.” These features of the disease suggest a convergence of environmental, genetic, immune and…
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Artikel Jurnal
Tortuous extracranial arteries contribute to white Matter hyperintensities in aging brains
IntroductionWhite matter hyperintensity (WMH) is a hallmark imaging biomarker of cerebral small vessel disease and are strongly associated with vascular cognitive impairment in the elderly. Morphological changes in large extracranial brain-feeding arteries, such as the internal carotid (ICA) and…
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Artikel Jurnal
Dysregulation of melatonin rhythm in Parkinson’s and Huntington’s disease: a systematic review and meta-analysis
BackgroundParkinson’s disease (PD) and Huntington’s disease (HD) are progressive neurodegenerative diseases with early non-motor symptoms, such as sleep disturbances, which often precede motor symptoms but are frequently overlooked. Although HD can be diagnosed genetically, PD lacks reliable…
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Artikel Jurnal
Impairment of human spatial orientation in the horizontal, but not the vertical plane, due to aging, cognitive decline, or chronic peripheral vestibular loss
IntroductionHumans and other vertebrates exhibit anisotropic orientation and navigation skills, with better performances in the horizontal compared to the vertical plane. While horizontal navigation accuracy decreases with higher age, less is known about age effects on vertical spatial abilities…
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Artikel Jurnal
In vivo quantification of superficial cortical veins on susceptibility-weighted imaging with artificial intelligence image segmentation and the potential mechanism of human cognitive decline
ObjectiveChanges in superficial cerebral veins (SCV) caused by different cognitive levels were observed using MR susceptibility-weighted imaging (MR-SWI) to explore the vascular mechanism underlying human brain aging and potential biomarkers of cognitive decline in vivo.MethodsThree hundred and…
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