8,223 results
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Journal Article
Rethinking cervical deep lymphovenous anastomosis in Alzheimer’s disease: problems and prospects
BackgroundDeep cervical lymphovenous anastomosis (DCLVA) has been proposed as a novel surgical strategy to promote brain waste clearance in Alzheimer’s disease (AD), inspired by advances in glymphatic and meningeal lymphatic research. Early reports suggested possible cognitive benefits, yet the…
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Journal Article
Efficacy and safety of robot-assisted vs. stereotactic framework deep brain stimulation for Parkinson’s disease: a retrospective study
BackgroundThis retrospective study aimed to compare the efficacy and safety of robot-assisted deep brain stimulation (DBS) vs. stereotactic framework DBS for Parkinson’s disease (PD).MethodsThe present study constituted a retrospective analysis that integrated a review of medical records with an…
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Journal Article
Neural correlates of prospective memory in Parkinson’s disease: a high-density EEG study
IntroductionProspective memory (PM), the ability to remember and execute intended actions in the future, is a critical component of daily functioning and independent living, particularly in individuals with Parkinson’s disease (PD). Although PM deficits in PD have been widely documented, their…
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Journal Article
Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson’s disease mouse model
IntroductionCurcumin exhibits potent neuroprotective properties but is limited by poor blood-brain barrier (BBB) permeability. This study aimed to evaluate whether focused ultrasound (FUS)-mediated BBB opening enhances curcumin delivery and therapeutic efficacy in a 6-hydroxydopamine (6-OHDA) mouse…
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Journal Article
Volumetric signatures of basal ganglia–thalamo–cortical and cerebello–thalamo–cortical networks in Parkinson's disease and its motor subtypes
IntroductionParkinson's disease (PD) is a systems-level disorder, implicating basal ganglia–thalamo–cortical (BTC) and cerebello–thalamo–cortical (CTC) networks. While regional atrophy has been reported, network-wide volumetric profiles and their relevance for subtype classification and symptom…
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Journal Article
Mechanistic modeling of amyloid dynamics relating to Alzheimer's disease progression
The use of mechanistic models to support personalized medicine and precision diagnostics offers transformative potential for neurology. In this study, we developed a mechanistic model of Alzheimer's Disease progression (mAD) that integrates amyloid precursor protein (APP) processing, Aβ peptide…
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Journal Article
Potential protein blood-based biomarkers for cognitive dysfunction in Parkinson’s disease: a systematic review and network meta-analysis
ObjectivesParkinson’s disease (PD) patients frequently develop mild cognitive impairment (PD-MCI) and may progress to Parkinson’s disease dementia (PDD). Despite progress in understanding PD pathophysiology, reliable blood-based biomarkers for early detection and monitoring of cognitive decline…
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Journal Article
Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging
Astaxanthin (AST), a xanthophyll carotenoid derived from microalgae and marine organisms, has emerged as a potent neuroprotective compound with remarkable antioxidant and anti-inflammatory properties. Growing evidence indicates that AST can modulate multiple molecular and cellular pathways involved…
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Journal Article
ZCCHC17: a target for synaptic dysfunction and neuronal excitability in Alzheimer’s disease
Epileptic activity and neuronal excitability have been reported in the setting of Alzheimer’s disease (AD), and may be linked to disease progression and severity. A shift in the excitation/inhibition balance to favor a more excitatory-dominant outcome appears to underlie the overall hyperactivity…
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Journal Article
APOE genotypes are associated with the level of naturally occurring antibodies to amyloid-β in patients with Alzheimer’s disease
Apolipoprotein E ε4 (APOEε4) allele is the strongest known genetic risk factor for Alzheimer’s disease (AD). Mechanisms underlying this association are incompletely understood. We aimed to determine whether APOE genotypes influenced the level of naturally occurring antibodies to amyloid-β (Aβ), a…
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Journal Article
Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats
BackgroundSleep is a fundamental biological process essential for maintaining mental, emotional, and physical health. Chronic sleep deprivation (SD), particularly in aging, is associated with oxidative stress, neuroinflammation, apoptosis, and cognitive and behavioral impairments. Oxytocin, a…
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Journal Article
Characterizing motor–cognitive associations in Parkinson’s disease using digital assessments
Traditional motor and cognitive assessments for people with Parkinson’s disease (PD) have long faced challenges related to accessibility, scalability, and geographical diversity when administered in-person. Remote cognitive testing offers the promise of improved accessibility, reduced participant…
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Journal Article
Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment
BackgroundPost-stroke cognitive impairment (PSCI) involves complex interactions between gray matter (GM) and white matter (WM) pathology, yet their covarying patterns remain poorly characterized.MethodsWe conducted a multimodal meta-analysis following PRISMA guidelines (PROSPERO registration…
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Journal Article
A transcriptomic resource for glial GABA-associated ASH neuronal aging and candidate pathways
IntroductionNeuronal aging is tightly linked to neurodegeneration with dysregulation of GABA (gamma-aminobutyric acid), the primary inhibitory neurotransmitter, contributing to age-associated neuronal impairment. Our prior work demonstrated that restoring the key GABA-synthesizing enzyme UNC-25…
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Journal Article
Cooling the burn: EMLA alone vs. paravertebral block plus EMLA for improving tolerability of 8% capsaicin patch application in thoracic postherpetic neuralgia—a retrospective cohort study
BackgroundThe 8% capsaicin patch (Qutenza®) is an effective localized treatment for postherpetic neuralgia (PHN), yet intense application-related burning pain remains a major barrier to its broader use. Optimizing procedural tolerability is particularly important in elderly patients who are…
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Journal Article
Putative sympathetic-predominant subtype in body-first Parkinson’s disease is associated with accelerated cognitive decline
BackgroundParkinson’s disease (PD) can be classified into brain-first and body-first subtypes based on the initial site of α-synuclein pathology. Postmortem studies further suggest that body-first PD may be divided into two phenotypes: sympathetic-predominant subtype (SPS) and…
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Journal Article
Association between end-tidal sevoflurane concentration and postoperative cognitive dysfunction and pain sensitivity in elderly patients under general anesthesia
ObjectiveTo analyze the association between end-tidal sevoflurane concentration and postoperative cognitive dysfunction (POCD) and pain sensitivity in elderly patients under general anesthesia.MethodsA total of 121 elderly patients undergoing abdominal surgery were enrolled and divided into a…
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Journal Article
Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H
Alzheimer’s disease (AD) poses a significant global health challenge, being the most prominent cause of dementia with prevalence increasing as the population ages. While the majority of AD cases are late-onset (LOAD), current animal models predominantly represent the more aggressive, faster…
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Journal Article
Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency
BackgroundX-linked dystonia-parkinsonism (XDP), an adult-onset neurodegenerative disorder, is caused by an SVA insertion in the TAF1 gene, containing a hexanucleotide, the length of which is correlated to the severity of the disease. The SVA insertion moderately disrupts gene expression; however…
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Journal Article
Electroacupuncture alleviates cognitive impairment in mice with vascular dementia by regulating the cholinergic vasodilation system
AimsElectroacupuncture (EA) is a potential and reliable treatment for vascular dementia (VaD). This study aims to explore the mechanism of EA in the treatment of VaD based on neurovascular coupling.MethodsThe VaD model was established by bilateral common carotid artery occlusion (BCCAO). Mice…
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