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Artikel Jurnal
Kynurenine pathway: a possible new mechanism for exercise in the prevention and treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease in clinical practice. The kynurenine pathway (KP) is a potential intersection of factors associated with the development of AD (central nervous inflammation, glutamate excitotoxicity, and tau phosphorylation, among others)…
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Artikel Jurnal
Cognitive changes preceding Parkinson's disease: a systematic review and meta-analysis of prospective population-based studies
IntroductionVarious non-motor symptoms have been studied as part of the prodromal phase of Parkinson's disease (PD). However, studies assessing cognitive changes are scarce.MethodsWe systematically searched PubMed and SCOPUS to identify prospective, population-based studies that reported on…
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Artikel Jurnal
The microbiota–gut–brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention
The microbiota–gut–brain axis (MGBA) is increasingly recognized as a critical regulator of brain health, influencing both neurodevelopment and age-related neurological decline. Disruptions in this axis, driven by gut dysbiosis, have been implicated in the pathogenesis of a wide range of…
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Artikel Jurnal
Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model
IntroductionWestern diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal white adipose tissue (eWAT), a representative VAT depot in rodents, plays a central role in WD-induced inflammation by secreting…
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Artikel Jurnal
Seeking the neural basis of neuropsychiatric symptoms in dementia: neuroimaging findings and controversies
The biological basis of neuropsychiatric symptoms (NPS) in individuals who have dementia is poorly understood, despite the significant burden on patients, caregivers, and communities. Recent neuroimaging advances have provided reliable and less-invasive methods to investigate human brains in vivo…
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Artikel Jurnal
Quantitative analysis of serum metabolites in a rat model of Alzheimer’s disease
ObjectiveOXYS rats are a unique animal model of sporadic Alzheimer’s disease (AD) that demonstrates all the key signs of AD in humans. Studying metabolic processes in OXYS rats in comparison with control Wistar rats can contribute to understanding the mechanisms of AD development, as well as to…
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Artikel Jurnal
Development and validation of a prognostic scoring system for cognitive decline in adults aged 50 and older in China
BackgroundWith the gradual aging of the global population, early identification and intervention are crucial for mitigating the negative impact of cognitive decline on patients and the healthcare system. This study aimed to develop and validate a prognostic scoring system for predicting cognitive…
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Artikel Jurnal
The impact of ondansetron on clinical outcomes in cranial surgery patients: a propensity-matched analysis of retrospective data
IntroductionCranial surgery represents a substantial public health challenge, characterized by intricate postoperative management that can complicate patient recovery. This study investigates the effect of ondansetron, a serotonin receptor antagonist, on clinical outcomes in adult patients…
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Artikel Jurnal
STING-mediated neuroinflammation: a therapeutic target in neurodegenerative diseases
The stimulator of interferon genes (STING) plays a crucial role as an adaptor in innate immune defense, orchestrating key inflammatory processes through the modulation of type I interferon signaling and activation of cytokine networks. Recent studies have identified STING-induced neuroinflammatory…
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Artikel Jurnal
Association of brain-derived neurotrophic factor in blood and cerebrospinal fluid with Parkinson’s disease and non-motor symptoms of Parkinson’s disease: a systematic review and meta-analysis of 6655 participants
BackgroundBrain-derived neurotrophic factor (BDNF) is essential for regulating neuronal proliferation and survival in neurodegenerative diseases, including Parkinson’s disease (PD). However, Studies on BDNF levels in peripheral blood and cerebrospinal fluid (CSF) have inconsistent results…
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Artikel Jurnal
Role of store-operated Ca2+ entry and STIM2 in retinal neurodegeneration during glaucoma
Ca2+ homeostasis is essential for glial cell activity and normal neuronal function, and store-operated Ca2+ entry (SOCE) is one mechanism that maintains it. The present review discusses the interplay between Ca2+ dysregulation and microglial activation in glaucomatous retinal degeneration. We…
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Artikel Jurnal
Risk factor analysis of cognitive frailty in older adults with type 2 diabetes mellitus: a cross-sectional study
BackgroundCognitive Frailty (CF), characterized by the co-occurrence of physical frailty and cognitive impairment without dementia, is a significant concern in older adults with Type 2 Diabetes Mellitus (T2DM). This study investigates the prevalence and risk factors of CF in this population…
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Artikel Jurnal
Effects of three aerobic exercise modalities (walking, running, and cycling) on circulating brain-derived neurotrophic factor in older adults: a systematic review and meta-analysis
BackgroundRecent studies indicate that older adults (aged 55 years and above) represent a critical period for changes in circulating brain derived neurotrophic factor (BDNF) levels and cognitive function. Regular aerobic exercise (AE) has been recognized as a promising non-pharmacological strategy…
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Artikel Jurnal
Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases
IntroductionAging is a normal process causing deterioration in normal brain function and is inevitable. The aging process is described by the buildup of senescent cells and a decline in the ability to maintain essential homeostatic functions. Cellular aging represents a critical process where cells…
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Artikel Jurnal
Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention
Hearing loss during early life has been linked to later cognitive decline, but the underlying neural mechanisms remain unclear. To investigate the cognitive impact of early hearing loss in humans, adults aged 18–40 years with severe childhood hearing loss were evaluated using standardized cognitive…
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Artikel Jurnal
Regional CSF volume quantification using deep learning for comparative analysis of brain atrophy in frontotemporal dementia subtypes
IntroductionFrontotemporal dementia (FTD) encompasses heterogeneous clinical syndromes, and distinguishing its subtypes using imaging remains challenging.MethodsWe developed a deep learning model to quantify brain atrophy by measuring cerebrospinal fluid (CSF) volumes in key regions of interest…
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Artikel Jurnal
The estrogen–brain interface in neuroinflammation: a multidimensional mechanistic insight
Neuroinflammation plays a dual role in the central nervous system, offering protection in acute phases but contributing to chronic damage in neurodegenerative diseases. Estrogen, traditionally recognized for its reproductive functions, exerts extensive neuroprotective effects by modulating…
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Artikel Jurnal
Dual improvement of cognitive function and auditory ability in elderly patients with hearing impairment by transcranial direct current stimulation-assisted auditory rehabilitation training
ObjectiveTo analyze the dual improvement effects of transcranial direct current stimulation (tDCS)-assisted auditory rehabilitation training on cognitive function and auditory ability of elderly patients with hearing impairment.Methods100 cases of elderly patients with hearing impairment admitted…
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Artikel Jurnal
Systemic inflammation versus clinical demographics: patient age surpasses the platelet-to-lymphocyte ratio in differentiating secondary trigeminal neuralgia
BackgroundObjective biomarkers to differentiate trigeminal neuralgia (TN) subtypes are lacking. This study aimed to evaluate the utility of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) for distinguishing primary TN from secondary TN caused by meningiomas (STN-M)…
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Artikel Jurnal
Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals
IntroductionBlood pressure (BP) physiologically dips during sleep, and a lack of dipping is associated with adverse health outcomes and cognitive decline. Vascular pulsatility is the primary driver of glymphatic cerebrospinal fluid (CSF) transport, which removes metabolic waste products from the…
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