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Influence of biological sex on neuroinflammatory dynamics in the aging brain
The aging brain undergoes complex neuroinflammatory changes that are increasingly recognized as contributing factors to the development and progression of neurodegenerative diseases. Emerging research reveals that biological sex profoundly shapes these neuroinflammatory dynamics, resulting in…
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Artikel Jurnal
Association between shift work and brain age gap: a neuroimaging study using MRI-based brain age prediction algorithms
BackgroundShift work is increasingly common and associated with numerous adverse health effects. Although studies show that shift work affects brain structure and neurological stress, its direct impact on brain aging remains unclear. Therefore, this study aims to investigate the association between…
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Artikel Jurnal
Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration
Postoperative delirium (POD) is a common and severe neuropsychiatric complication affecting older adults after surgery. POD is characterized by fluctuating cognitive disturbances, impaired attention, and altered consciousness, resulting in increased morbidity and mortality, prolonged hospital…
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Artikel Jurnal
Associations between peripheral nerve stimulation and cognitive performance: insights from healthy individuals and various disease pathologies
Cognitive dysfunction can manifest as declines in memory, learning, and attention, stemming from multifaceted factors. Risk factors encompass a spectrum including genetics, lifestyle choices, and personal medical history. Conditions such as Alzheimer’s disease (AD), depression, epilepsy, and…
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Artikel Jurnal
Cognitive deterioration in patients undergoing hemodialysis: how variations in age influence the development of new mechanisms and treatment approaches?
The mechanisms of age-related differences and innovative intervention strategies for cognitive dysfunction in hemodialysis patients are crucial for enhancing patient outcomes. This research thoroughly examined the varying pathological aspects of cognitive decline across different age groups…
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Artikel Jurnal
Associations of plasma von Willebrand Factor levels with cognitive decline and neurodegeneration in older adults without dementia
BackgroundPrevious studies have suggested that von Willebrand Factor (VWF) may be implicated in the pathogenesis of Alzheimer’s disease (AD). However, the association between plasma VWF levels and cognitive decline and neurodegeneration in older adults without dementia remains unclear.MethodsWe…
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Artikel Jurnal
Muscle strength, EEG biomarkers, and working memory as interacting predictors of cognitive function in cognitively impaired older adults
BackgroundCognitive decline in older adults is a pressing public health concern, with emerging evidence suggesting that both muscle strength and neural function may influence cognitive outcomes. However, the integrative mechanisms linking these domains remain insufficiently understood.ObjectiveThis…
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Artikel Jurnal
Effects of transcranial alternating current stimulation on neurophysiologic motor function in Parkinson’s patients: a systematic review and meta-analysis
ObjectiveThis systematic review and meta-analysis aimed to evaluate whether tACS improves neurophysiologic motor function in patients with Parkinson’s patients.MethodsWe searched PubMed, Embase, Web of Science, and Cochrane Library for eligible studies from inception to March 2025. Measured…
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Artikel Jurnal
Corpus callosum microstructure in chimpanzees (pan troglodytes): associations with age, handedness and cognition
Studies on the human brain have emphasized the loss of gray matter volume and decreased thickness during normal aging, along with variations in the density of small axon fibers across different regions of the corpus callosum (CC). Here, we investigated age-related changes in white matter…
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Artikel Jurnal
The mediating role of depression on the association between physical activity and cognitive function among older adults
BackgroundPrevious studies had showed that physical activity (PA) can effectively reduce cognitive decline. Nonetheless, it is still unclear whether depression can mediate the relationship between PA and cognitive decline.MethodsThis study encompassed 2,681 older adults (≥ 60 years) from the…
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Artikel Jurnal
Explainable machine learning for early detection of Parkinson’s disease in aging populations using vocal biomarkers
IntroductionParkinson’s Disease (PD) is a progressive neurodegenerative disorder that significantly affects the aging population, creating a growing burden on global health systems. Early detection of PD is clinically challenging due to the gradual and ambiguous onset of symptoms.MethodsThis study…
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Artikel Jurnal
Cognitive behavioral therapy for anxiety and depression symptoms in people of Parkinson’s disease: a systematic review and meta-analysis
ObjectivesWe aim to conducted a systematic review and meta-analysis of published RCTs (Randomized Controlled Trials, RCTs) to quantify the effects of CBT (Cognitive behavioral therapy, CBT), including both remote and in-person modalities, on anxiety, depressive symptoms, and QoL (Quality of Life…
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Artikel Jurnal
Effects of different frequencies of repetitive transcranial magnetic stimulation on sleep disorders and depression in patients with Parkinson’s disease: a systematic review and network meta-analysis
BackgroundRepetitive transcranial magnetic stimulation (rTMS) has emerged as a promising neuromodulatory approach for alleviating sleep disturbances and depressive symptoms in Parkinson’s disease (PD), yet direct comparisons of different stimulation frequencies remain scarce.ObjectiveTo evaluate…
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Artikel Jurnal
The association between chronic rhinosinusitis and the risk of dementia: a longitudinal study
BackgroundChronic inflammation status could increase the risk of dementia, and chronic rhinosinusitis (CRS) could cause chronic inflammation status. Therefore, CRS may be associated with dementia. The aim of our study was to investigate the association between CRS and the risk of dementia in the UK…
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Artikel Jurnal
Biomarkers of balance and gait deficits in FMR1 premutation carriers: a mini-review
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a premutation (PM) of the FMR1 gene on the X chromosome. FXTAS is characterized by intention tremor, ataxia, and cognitive decline. Age-related cognitive-behavioral and sensorimotor (i.e., balance and…
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Artikel Jurnal
Role of lipocalin-2 in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized pathologically by degeneration of upper and lower motor neurons, ultimately leading to muscle weakness and respiratory failure. Lipocalin-2 (LCN2) is a secreted protein involved in lipid transport that…
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Artikel Jurnal
Predictive gene expression signatures for Alzheimer’s disease using post-mortem brain tissue
BackgroundAlzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and tau protein aggregates in the brain. These pathological features manifest in specific regions, but mechanisms rendering some areas more susceptible to early AD-related…
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Attention-based Transformer-LSTM architecture for early diagnosis and staging of early-stage Parkinson’s disease using fNIRS data
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder requiring early diagnosis and accurate staging for optimal treatment outcomes. Traditional clinical assessments have limitations in objectivity and reproducibility.ObjectiveTo develop and validate an Attention-based…
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Artikel Jurnal
Clinical validation of a plasma-based antibody-free LC–MS method for identifying CSF amyloid positivity in mild cognitive impairment
BackgroundThe recent approval of monoclonal antibodies for the treatment of Alzheimer’s disease (AD) in several countries has accelerated the need for affordable, simple and scalable methods to identify patients who are eligible for treatment with the new disease-modifying therapies (DMT)…
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