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Asrij/OCIAD1 contributes to age-associated microglial activation and neuroinflammation in mice
Aging is characterized by chronic low-grade neuroinflammation, which increases the risk of neurodegenerative disorders. Neuroinflammation, driven by the activation of astrocytes and microglia, underlies age-associated cognitive deficits. Amplified neuroinflammatory responses to immune challenges…
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Metabolic Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in the substantia nigra. While most cases are sporadic, there is growing evidence of a link between PD and metabolic dysfunctions such as type 2 diabetes mellitus, obesity, and…
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Artikel Jurnal
Deciphering Alzheimer’s disease transcriptomics: exploration and validation of core genes in tau and Aβ pathological models toward novel therapeutic targets
IntroductionTo decode the pathology of Alzheimer’s disease (AD), this study employs multi-omics approaches and bioinformatics analyses to explore AD-associated differentially expressed genes (DEGs), dissect the underlying mechanisms, and thereby facilitate the identification of core genes as well…
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Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis
IntroductionAlzheimer’s disease and other dementias (ADOD) represent a growing global health crisis driven by the rapid aging of the population. Using data from the 2021 Global Burden of Disease (GBD) study, we provide updated global and national estimates of the ADOD burden from 1990 to 2021…
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Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults
BackgroundSleep–wake rhythms are critical for the development of Alzheimer’s disease (AD). However, the relationship of sleep disturbance, APOE ε4, and amyloid-β (Aβ) accumulation remains unclear. Thus, this study investigated the potential role of APOE ε4 allele in the association between sleep…
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Artikel Jurnal
The effects of Nordic walking on cognitive function in older adults: a systematic review and meta-analysis
ObjectivesNordic walking (NW), as a specialized form of aerobic exercise, emerges as a promising strategy to improve the cognitive function in older population. However, the effectiveness of NW has yet to be definitively confirmed due to the variances in the study designs and observations. This…
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EEG-based minimum spanning tree analysis reveals network disruptions in Alzheimer’s disease spectrum: an observational study
IntroductionAlzheimer’s disease (AD) is characterized by disrupted brain connectivity, but the network changes across disease stages remain poorly understood. This observational cross-sectional study investigated alterations in functional brain networks across the AD continuum using minimum…
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Artikel Jurnal
Understanding Parkinson’s disease: current trends and its multifaceted complications
BackgroundParkinson’s disease (PD) is a multifactorial, progressive neurodegenerative disorder that primarily affects dopaminergic neurons in the substantia nigra. In addition to hallmark motor symptoms, it manifests a wide range of nonmotor complications, including cognitive decline…
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Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults
BackgroundCardiovascular disease (CVD) and its associated risk factors accelerate neurodegeneration and cognitive decline. This study examined relationships between CVD risk, cognition, and Brain Age Gap (BAG)—the difference between MRI-predicted brain age and chronological age. While prior…
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Beyond traditional proxies: the contribution of leisure to cognitive reserve and dementia
IntroductionCognitive reserve (CR) is a multidimensional construct based on lifelong engagement in cognitively stimulating domains, including education, occupation and leisure activities, that plays a crucial role in mitigating the presentation of dementia. To date, the contribution of each CR…
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Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction
BackgroundDynamic functional network connectivity (dFNC) assesses temporal fluctuations in functional connectivity (FC) during magnetic resonance imaging (MRI), capturing transient changes in neural activity. Investigating dFNC may provide valuable insights into the complex clinical manifestations…
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Artikel Jurnal
Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson’s disease
IntroductionTremor is a prevalent and disabling motor symptom in Parkinson’s disease (PD). The role of the serotonergic system in Parkinsonian tremor remains unclear. We aimed to investigate whether functional connectivity (FC) of the dorsal (DRN) and median (MRN) raphe nuclei is associated with…
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A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson’s disease: model development, external validation, and local deployment
BackgroundDespite substantial progress in biomarker research, Parkinson’s disease (PD) still lacks widely validated, easily deployable diagnostic tests for reliable early-stage detection, particularly in resource-limited circumstances.ObjectiveThis study aimed to develop and externally validate a…
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Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus
IntroductionMild cognitive impairment (MCI) represents the initial stage of dementia, and early diagnosis is crucial in clinical practice. This study aimed to investigate the predictive performance of three models based on clinical features, radiomics features of hippocampal T1-weighted imaging…
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Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats
BackgroundAlzheimer’s disease (AD) pathology begins two or three decades prior to the onset of cognitive symptoms and is characterized by amyloid-β (Aβ) and hyperphosphorylated tau (pTau) accumulation, reactive glial cells, increased inflammation, and neuronal degeneration in later stages…
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Dexmedetomidine ameliorates cognitive and affective deficits by modulating neuroinflammation and neurogenesis in an Alzheimer’s disease mouse model
Alzheimer’s disease (AD) involves progressive cognitive decline and neuropsychiatric symptoms that are strongly linked to neuroinflammation and aberrant hippocampal neurogenesis. We examined whether dexmedetomidine (Dex), a clinically used selective α2-adrenergic agonist, could mitigate…
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HALP, PIV, and SII as novel composite inflammatory indices for early detection and severity assessment of Alzheimer’s disease
ObjectiveThis study aimed to evaluate the diagnostic and prognostic value of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score, the Pan-Immune-Inflammation Value (PIV), and the Systemic-Immune-Inflammation Index (SII) in Alzheimer’s disease (AD), exploring their association with…
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Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs
IntroductionParkinson’s disease (PD) has become the fastest-growing neurological disease worldwide. This network meta-analysis evaluated the efficacy of transcranial stimulation combined with four rehabilitation approaches for improving gait and motor function in Parkinson’s disease.MethodsWe…
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Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review
BackgroundParkinson’s disease (PD) is traditionally defined by dopaminergic degeneration and α-synuclein aggregation. However, mounting evidence supports a multifactorial and systemic pathophysiology that extends beyond the central nervous system. This narrative review explores the interconnected…
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