8.223 hasil
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Artikel Jurnal
Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus
ObjectivesTo evaluate cognitive and mood changes 3 months after shunting for idiopathic normal-pressure hydrocephalus (iNPH), and compare postoperative outcomes with matched healthy controls across cognitive domains.MethodsThirty-three iNPH patients underwent neuropsychological testing…
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Artikel Jurnal
Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study
IntroductionUrinary dysfunction is a common non-motor symptom in patients with Parkinson’s disease (PD) and is often associated with greater motor disability and reduced quality of life. Despite its clinical relevance, the association between motor symptom severity and urinary dysfunction remains…
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Artikel Jurnal
Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease
Parkinson’s disease (PD) is the selective demise of dopaminergic neurons in the substantia nigra. Conventional neuroprotective strategies based on exogenous antioxidants have shown minimal clinical efficacy. Emerging evidence suggests that neuronal loss in PD may stem not only from direct…
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Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism
IntroductionAlzheimer’s disease (AD) is a neurodegenerative disease that can only be managed rather than cured, bringing a substantial burden to society. Frailty and cognition are intertwined in a cycle of decline, affecting the prognosis of AD. Qi-Fu-Yin (QFY) is a classic prescription in…
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Artikel Jurnal
Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study
BackgroundCognitive frailty has recently drawn increasing attention in the context of elderly healthcare. While structural brain alterations in older adults with cognitive frailty have been previously explored, functional brain changes particularly during cognitive-motor tasks remain poorly…
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Structural and microstructural changes in white and gray matter across the Alzheimer’s disease continuum
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive brain atrophy, with pathological progression accompanied by significant structural alterations in both gray matter (GM) and white matter (WM). This review summarizes the neuroimaging features and clinical…
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Self-reported hopefulness and cognitive function: the moderating effect of physical activity in older adults without cognitive impairment
BackgroundWith dementia cases rising globally, identifying modifiable psychological factors that support cognitive resilience is crucial. Hopefulness, an optimistic emotional state, may serve as a protective factor against cognitive decline. However, its role in cognitively normal (CN) individuals…
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Artikel Jurnal
Effects of glucocerebrosidase gene variations on the risk of Parkinson’s disease dementia: a meta-analysis
ObjectiveThis meta-analysis aimed to investigate the effects of glucocerebrosidase gene (GBA) variations on the risk of Parkinson’s disease dementia (PDD) and to identify the relationship between GBA variations and PDD.MethodA comprehensive search was performed to retrieve publications from PubMed…
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Artikel Jurnal
Interpretable machine learning for cognitive impairment prediction in Parkinson’s disease: a multicenter validation study with SHAP analysis
IntroductionParkinson’s disease (PD)-related cognitive impairment (PD-CI) is a common and impactful complication of PD, yet current predictive models often rely on specialized resources, lack interpretability, or have limited cross-population validation. This study aimed to develop an interpretable…
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Artikel Jurnal
Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is the most prevalent neurodegenerative disease associated with aging. While deep brain stimulation (DBS) shows therapeutic promise, the long-term persistence of its effects remains understudied. Expression patterns of circulating miRNAs, proposed diagnostic…
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Artikel Jurnal
Increased free water in the nucleus basalis of Meynert is associated with worse olfaction in idiopathic Parkinson’s disease
BackgroundThe association of cholinergic degeneration and olfactory function in Parkinson’s disease (PD) is unclear. Using free water imaging, this study aims to investigate the association between the nucleus basalis of Meynert (NBM) degeneration and olfactory function in patients with PD.MethodsA…
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Artikel Jurnal
Dynamic decline in estimated glomerular filtration rate associated with in-hospital mortality risk in acute ischemic stroke patients after endovascular therapy: evidence from a Chinese stroke center
ObjectivesTo investigate the association between dynamic changes in estimated glomerular filtration rate (eGFR) and in-hospital mortality risk in patients with acute ischemic stroke due to large vessel occlusion (LVO-AIS) undergoing endovascular therapy (EVT).MethodsThis retrospective cohort study…
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Biological determinants of blood-based biomarker levels in Alzheimer’s disease: role of nutrition, inflammation, and metabolic factors
ObjectivesThe review discusses the effect of biological determinants such as nutritional deficiency, systemic inflammation, and metabolic disorders affect blood-based biomarker (BBBM) levels, influencing their use in diagnosing, prognosticating, and treatment in Alzheimer’s disease (AD). While the…
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Artikel Jurnal
A trajectory study of postoperative frailty and cognitive function in elderly spinal surgery patients: a cohort study in China
ObjectiveTo explore the developmental trajectory of postoperative frailty and cognitive function in elderly spinal surgery patients and the predictive relationship between the two.MethodsA total of 266 elderly individuals were selected as the study subjects, and their debilitation and cognitive…
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Artikel Jurnal
Cross-generational mechanisms of maternal gut microbiota in modulating offspring autism spectrum disorder risk: from the gut-brain axis to translational challenges in precision interventions
Autism Spectrum Disorder (ASD) manifests as a group of neurodevelopmental disorders with high clinical and genetic heterogeneity, characterized by core features including social communication deficits, repetitive behaviors, and restricted interests. Current research primarily focuses on genetic…
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Artikel Jurnal
Influence of diabetes on the efficacy of DL-3-n-butylphthalide in post-stroke cognitive impairment: a 12-month prospective cohort study
ObjectiveDiabetic chronic hyperglycaemia amplifies oxidative stress, microvascular injury, and insulin-resistant neuroinflammation, counteracting the pro-angiogenic, mitochondrial-protective, and anti-apoptotic effects of DL-3-n-butylphthalide (NBP). It remains unknown whether glycaemic status…
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Variations in body condition score, inflammatory and metabolic biomarkers predict cognitive changes in clinically healthy senior cats
ObjectivesThe present study aimed to identify immune, metabolic, and hematological biomarkers, among those commonly monitored in clinical practice, that are predictive of age-related behavioral and cognitive changes in clinically healthy elderly cats, with the objective of highlighting potential…
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Brain microenvironment orchestrates highly aggressive tumor variants: current trends and therapeutic approaches
Brain tumors exhibit some of the major challenges in the field of oncology owing to their highly heterogeneous, complex, and aggressive nature. The complex anatomy and aggressiveness of the cancer contribute to high mortality and morbidity worldwide. Moreover, the complexity of genetic mutations…
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Artikel Jurnal
From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis
IntroductionAge-related hearing loss (ARHL) is a common chronic condition that significantly affects the quality of life in older adults. Studies have shown that genetic factors play a substantial role in ARHL, with heritability estimates ranging from 46 to 74%. Although advances in genomics and…
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Artikel Jurnal
Astrocytic Ror2-induced imbalance in brain and gut homeostasis contributes to chronic post-thoracotomy pain
BackgroundReceptor tyrosine kinase-like orphan receptor 2 (Ror2) plays an indispensable role in mediating acute and chronic pain. We previously demonstrated the involvement of spinal cord astrocyte-derived Ror2 in chronic post-thoracotomy pain (CPTP). Here, we further investigated the roles of…
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