8.223 hasil
Menampilkan 861–880 · 0,39 detik · RSS
-
Artikel Jurnal
Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease
Although impaired insulin signaling in the brain has been recognized as a key factor in the development and progression of Alzheimer’s disease (AD), the underlying mechanisms remain incompletely understood. Given that overactivation of cytosolic phospholipase A2 (cPLA2) has been implicated in AD…
-
Artikel Jurnal
Exercise modulation of gut microbiota in Alzheimer’s disease: pathophysiological mechanisms and therapeutic perspectives
As global life expectancy increases, Alzheimer’s disease (AD) has become a major public health concern. The gut microbiota plays a pivotal role in regulating the central nervous system, influencing both behavior and cognitive functions in AD through direct and indirect mechanisms. Physical exercise…
-
Artikel Jurnal
Integrated analysis of N-glycosylation and Alzheimer’s disease: identifying key biomarkers and mechanisms
BackgroundAlzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, imposing a significant societal burden. Current therapeutic approaches primarily address symptoms, underscoring the critical need to elucidate its pathogenesis and identify robust early biomarkers…
-
Artikel Jurnal
Glymphatic system impairment in cerebral small vessel disease: associations with perivascular space volume and cognition
ObjectiveWhile emerging evidence links glymphatic dysfunction to cerebral small vessel disease (CSVD), its clinical relevance remains poorly defined. This study aimed to investigate the relationships among glymphatic function, perivascular space (PVS), and cognitive performance in CSVD.MethodsWe…
-
Artikel Jurnal
Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS
BackgroundCognitive dysfunction is a common impairment observed in individuals with Multiple Sclerosis (MS), affecting key domains such as attention, information processing speed, memory, and executive functions. This deficit is typically identified through comprehensive neuropsychological…
-
Artikel Jurnal
Excitatory-inhibitory imbalance in temporal lobe epilepsy: a 5T multimodal MRI biomarker for focus localization and drug resistance stratification
This study aimed to investigate the diagnostic value of combined glutamate chemical exchange saturation transfer (GluCEST) imaging and γ-aminobutyric acid (GABA)-edited proton magnetic resonance spectroscopy (1H-MRS) in localizing epileptogenic foci and differentiating drug-resistant epilepsy (DR)…
-
Artikel Jurnal
Peak alpha frequency as an objective biomarker for cognitive assessment in post-stroke cognitive impairment
ObjectiveTo investigate regional associations between peak alpha frequency (PAF) and poststroke cognitive impairment (PSCI) and evaluate PAF as an objective biomarker for cognitive assessment in PSCI.MethodsA cross-sectional study compared 103 participants [PSCI, poststroke non-impaired (PSN), and…
-
Artikel Jurnal
Multimodal radiomics of cerebellar subregions for machine learning-driven Alzheimer’s disease diagnosis
ObjectiveThis study aimed to develop a machine learning model based on multimodal radiomics features from cerebellar subregions, utilizing the complementarity of cerebellar structural and metabolic imaging data for accurate diagnosis of Alzheimer’s disease (AD).MethodsA total of 164 cognitively…
-
Artikel Jurnal
Chronic kidney disease, proteinuria, and mortality risk in patients with Parkinson’s disease: a 12-year longitudinal study
BackgroundVarious comorbidities contribute to mortality in patients with Parkinson’s disease (PD). Although growing evidence demonstrates that chronic kidney disease (CKD) increases the risk of developing PD, the effect of CKD on all-cause mortality remains unclear.MethodsWe enrolled 59,293…
-
Artikel Jurnal
The effects of type 2 diabetes mellitus on postural adaptation and complexity during a visual search task in older adults
BackgroundType 2 diabetes mellitus (T2DM) negatively impacts both the peripheral and central systems involved in postural control, leading to impairments, especially under dual-task conditions. This study investigated the effects of T2DM on postural sway using single- and multi-scale metrics during…
-
Artikel Jurnal
Aerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson’s disease
BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder. It is marked by motor dysfunction and cognitive decline. In recent years, scientific studies have found that PD’s pathogenesis may be tied to an imbalance in the gut microbiota. This offers new perspectives for PD treatment…
-
Artikel Jurnal
Levodopa-induced dyskinesia in Parkinson’s disease: an updated review of pharmacological treatments
Levodopa-induced dyskinesia (LID) remains one of the most disabling complications of long-term dopaminergic therapy in Parkinson’s disease. Despite decades of investigation, only amantadine has been established as the standard FDA-approved treatment, while istradefylline provides a complementary…
-
Artikel Jurnal
Oscillatory dynamics of motor learning across adulthood life span: a systematic review
Motor learning refers to a set of processes associated with practice and experience that are essential for acquiring new skills and adapting behavior throughout the lifespan. Mastery of motor skills plays a crucial role in maintaining autonomy and quality of life, particularly in aging populations…
-
Artikel Jurnal
Peripheral immunity patterns, imaging features, and clinical outcomes in patients with gait impairment and ventriculomegaly on brain MRI
IntroductionVentricular enlargement is a common finding on brain MRI in patients with gait impairment, particularly in those with idiopathic normal pressure hydrocephalus (iNPH). However, iNPH shares several clinical and radiological features with neurodegenerative diseases, which complicates…
-
Artikel Jurnal
Translational insights into pain mechanisms and balance impairments in aging: a cross-sectional study
ObjectivesThis study aimed to investigate the association between pressure pain threshold (PPT), pain intensity, pain catastrophizing, and postural stability and to assess the impact of pain chronicity and duration on functional reach and posturographic outcomes in community-dwelling older…
-
Artikel Jurnal
Gender-related differences in cognitive performance and cognitive stimulation efficacy in subjects with Parkinson’s disease and mild cognitive impairment
BackgroundGender-related differences in cognitive performances of subjects with Parkinson’s Disease and mild cognitive impairment (MCI-PD) have been recently investigated in a few studies, yielding heterogeneous results. Cognitive stimulation (CS) is a promising non-pharmacological treatment in…
-
Artikel Jurnal
Top motor and non-motor complaints in patients with Parkinson's disease
BackgroundParkinson's disease (PD) is characterized by several motor and non-motor manifestations. These variable neurological complaints have diverse intensity and cause various degrees of disability.Objective methodsWe aimed to assess the top three most troublesome neurological complaints in…
-
Artikel Jurnal
Stressors-induced cognitive dysfunction during aging: mechanisms and future challenges
Stressful events can lead to transient impairments in learning and memory, a phenomenon more pronounced in the elderly. As global life expectancy rises, the shift toward an aging society underscores the urgent need for effective preventive strategies against stress-induced cognitive dysfunction…
-
Artikel Jurnal
Diagnostic classification of mild cognitive impairment in Parkinson's disease using subject-level stratified machine-learning analysis
BackgroundThe timely identification of mild cognitive impairment (MCI) in Parkinson's disease (PD) is essential for early intervention and clinical management, yet it remains a challenge in practice.MethodsWe conducted an analysis of 3,154 clinical visits from 896 participants in the Parkinson's…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.