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Artikel Jurnal
Baseline CSF ferritin levels were associated with trajectories of depressive symptoms among older people without dementia
BackgroundPrevious studies have suggested a link between ferritin levels in the blood and depressive symptoms. However, no prior studies have investigated the association between cerebrospinal fluid (CSF) total ferritin, ferritin light chain, and ferritin heavy chain and longitudinal changes in…
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Artikel Jurnal
Elucidating the role of APOE ε4 gene variants in the clinical manifestation of Parkinson's disease
IntroductionParkinson's Disease (PD) is the most common movement disorder, and remains a major cause of mortality and morbidity worldwide. Studies have uncovered the potential role of the Apolipoprotein (APOE) gene in PD, although results have been conflicting. This study aimed to characterize the…
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Five-year dementia prediction and decision support system based on real-world data
IntroductionThis work presents a machine learning (ML) based risk prediction model for Alzheimer's disease and related dementias, utilizing real-world electronic health record (EHR) clinical data. While significant research has been conducted on dementia risk prediction, most studies rely on…
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Diagnostic utility and psychometric properties of the Technology Activities of Daily Living Questionnaire (T-ADLQ) in people with non-formally educated with Alzheimer’s disease in Lima, Peru
ObjectiveTo evaluate the discriminative capacity and psychometric properties of the Technology–Activities of Daily Living Questionnaire (T-ADLQ) in distinguishing cognitively unimpaired individuals from those with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease dementia (ADD) in a…
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Artikel Jurnal
MRI-derived global small vessel disease burden serves as a marker of hippocampal sclerosis and clinical stage across the probable Alzheimer’s disease continuum
IntroductionCerebral small vessel disease (SVD) contributes to cognitive decline and hippocampal sclerosis (HS), yet its role across the Alzheimer’s disease (AD) continuum remains incompletely understood. We aimed to determine whether composite MRI-based SVD scores serve as markers of cognitive…
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Artikel Jurnal
Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies
BackgroundPisa syndrome (PS), characterized by trunk lateral flexion, remains rarely reported in dementia with Lewy bodies (DLB). While its pathogenesis is multifactorial, underlying mechanisms are not fully understood. Given the established link between postural control and cognition in aging…
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Artikel Jurnal
Neuroimmune dynamics and brain aging: mechanisms and consequences
Brain aging is accompanied by profound changes in neuroimmune interactions that shape the balance between resilience and vulnerability. Under healthy conditions, glial cells, neurons, vascular elements, and peripheral immune inputs cooperate to sustain homeostasis. With advancing age, however…
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Artikel Jurnal
Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study
ObjectiveTo characterize abnormal functional connectivity in dementia with Lewy bodies (DLB) and its association with cognitive impairment using resting-state functional magnetic resonance imaging (rs-fMRI).MethodsSixty-eight DLB patients and 38 age-, sex-, and education-matched healthy controls…
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Artikel Jurnal
Current application status of non-invasive brain stimulation techniques in Alzheimer’s disease: a bibliometric analysis
ObjectiveAlzheimer’s disease (AD) poses a significant global public health challenge. Non-invasive brain stimulation (NIBS) has emerged as a promising therapeutic strategy and constitutes a rapidly evolving research domain for AD intervention. This study aims to synthesize recent advancements in…
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Artikel Jurnal
Singing for memory: neural and cognitive effects of a choral intervention in older adults
IntroductionLifestyle factors are important predictors of successful aging, and targeted interventions could be key to mitigating the negative effects of aging. Episodic memory is of particular interest as it is notably sensitive to aging. Given the social, intellectual, and physical stimulation…
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Artikel Jurnal
Vitamin D-linked vulnerability and functional connectivity alterations in the superior frontal gyrus contributing to cognitive impairment in Parkinson’s disease
Background and aimsForecasting specific factors influencing cognitive impairment (CI) in Parkinson’s disease (PD) patients can improve clinical outcomes. This study aims to identify brain areas vulnerable to vitamin D deficiency and assess functional integrity in PD patients with and without…
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Artikel Jurnal
Is cognitive reserve associated with cognitive function across stroke severity? A longitudinal study among Chinese stroke patients
BackgroundCognitive decline is common after stroke. This study assessed the longitudinal associations between cognitive reserve and post-stroke cognitive function and tested whether these associations differ across patients’ stroke severity.MethodsA longitudinal survey was conducted among 371…
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Artikel Jurnal
Decanoic acid, an MCT dietary component, alleviates cognitive impairment, cellular senescence, and promotes autophagy in accelerated aging and neurotoxic mouse models induced by chronic administration of D-galactose and D-galactose/AlCl3
IntroductionCognitive decline advances with age, increasing the risk of dementia and Alzheimer’s disease among older adults. Medium-chain triglyceride (MCT) ketogenic diets have shown potential in slowing down age-related cognitive decline; however, the exact neuroprotective roles of MCT…
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Artikel Jurnal
Improving recognition and management of inpatient delirium in Parkinson’s disease: evidence review and implications for clinical care
Delirium is an acute disturbance of attention, arousal, and cognition that fluctuates in severity and is a common yet under recognized complication in hospitalized patients with Parkinson’s disease. In Parkinson’s disease, symptoms such as rigidity, bradykinesia, hallucinations, and slowed thinking…
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Artikel Jurnal
An intricate relationship: stress markers and associative memory in a laboratory experiment in older adults
IntroductionResearchers working in the field of cognitive aging frequently encounter highly motivated yet nervous older participants during data collection in the laboratory. Such anecdotal experiences raise the question of whether the affective or physiological response of older participants to…
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Artikel Jurnal
Drug discovery and development for Parkinson’s disease: are preclinical models good enough?
Parkinson’s disease (PD) remains a major challenge for translational neuroscience, with an increasing global prevalence and persistent unmet therapeutic needs. While its classical motor symptoms, such as bradykinesia, rigidity, and tremor, are well characterized, the clinical spectrum extends to…
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