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Artikel Jurnal
Directed brain connectivity biomarkers of healthy aging and Parkinson’s disease staging
IntroductionThe propagation of neural signals across various brain regions requires us to understand directional connectivity in functional magnetic resonance imaging (fMRI) data. We employ temporal partial directed coherence (TPDC), a data driven method to explore directional connectivity in young…
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Artikel Jurnal
Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults
IntroductionCognitive frailty, defined by the coexistence of mild cognitive impairment and physical frailty, imposes greater risk of negative health consequences than either condition alone. Cognitive intraindividual variability (IIV), which reflects the extent of fluctuation in cognitive…
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Artikel Jurnal
Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin
IntroductionRNA expression is modulated by tau. We used two mouse models, THY-Tau22 mice, which express pro-aggregation tau, and TauKO mice, which are null for tau, to improve our understanding of tau-altered mRNA expression in brain.MethodsSpatial transcriptomics on Tau22 and TauKO mice were used…
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Artikel Jurnal
Prevalence, associated factors and impact of mild cognitive impairment in hospitalized older adults with Parkinson’s disease: a cross-sectional study
BackgroundEarly identification of mild cognitive impairment (MCI) and timely interventions are essential to delay dementia in Parkinson’s disease (PD). This study aims to examine the prevalence of MCI among hospitalized older adults with PD, preliminarily identify related factors, and explore its…
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Artikel Jurnal
Association between periodontal disease and Alzheimer's disease: a scoping review
BackgroundAlzheimer's disease (AD) is the most common type of dementia, with mild cognitive impairment (MCI) as its early reversible stage. Periodontal disease (PD) is a chronic inflammatory condition associated with systemic diseases. Recent studies suggest a potential link between PD and AD/MCI…
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Artikel Jurnal
Effectiveness and safety of acupuncture for Parkinson’s disease anxiety: a systematic review and meta-analysis
BackgroundIndividuals with Parkinson’s disease (PD) commonly experience anxiety, with a prevalence of 31%. This study systematically evaluates the efficacy and safety of acupuncture for anxiety related to PD.MethodNine databases were searched for randomized controlled trials (RCTs) published from…
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Artikel Jurnal
Quantitative analysis of gait and balance using deep learning on monocular videos and the timed up and go test in idiopathic normal-pressure hydrocephalus
BackgroundA vision-based gait analysis system using deep learning algorithms for simple monocular videos was validated to estimate temporo-spatial gait parameters in idiopathic normal-pressure hydrocephalus (INPH) patients. The Timed Up and Go (TUG) test has been used to reflect risk of falling in…
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Artikel Jurnal
Copper homeostasis and cuproptosis: implications for neurodegenerative diseases
Copper (Cu) is a vital trace element required for sustaining life and is involved in numerous critical metabolic processes within the body. Cuproptosis, a newly recognized type of Cu-dependent cell death, is mechanistically distinct from apoptosis, autophagy, pyroptosis, and ferroptosis. It is…
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Artikel Jurnal
Mediating role of brain aging in the effect of white matter hyperintensities on post-stroke aphasia severity
ObjectivesWhite matter hyperintensities (WMH) have been associated with the severity of post-stroke aphasia (PSA), but the contribution of overall brain health remains unclear. Brain age is a neurobiological indicator of aging that is based on whole-brain structural neuroimaging. This study…
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Artikel Jurnal
Characterizing sleep-related phenotypes with patient-reported outcomes in Parkinson’s disease
ObjectiveSleep disturbances are common in Parkinson’s disease (PD) and significantly impact patients’ quality of life. However, the clinical symptoms associated with poor sleep remain underexplored. The Patient-Reported Outcomes in PD (PRO-PD) is a remote patient monitoring tool enabling…
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Artikel Jurnal
LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment
IntroductionThe concept of cognitive resilience (CR) has emerged to explain the lack of correlation between the extent of brain lesions and the severity of cognitive symptoms in Alzheimer’s disease (AD), but the underlying mechanisms remain poorly understood.MethodsTo investigate this, we developed…
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Artikel Jurnal
Effect of various acupuncture courses for upper limb motor dysfunction after ischemic stroke: a Bayesian network meta-analysis
BackgroundAcupuncture has been widely used in the treatment of post-ischemic stroke upper limb motor dysfunction (PIS-ULMD). However, previous studies have reported substantial variability in acupuncture courses, and the lack of a clearly defined optimal course has impeded further improvement in…
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Artikel Jurnal
Research progress on the interaction between multiple organ-brain axes and perioperative neurocognitive disorders: a narrative review
Perioperative neurocognitive disorder (PND) is a common central nervous system complication during the perioperative period, characterized by memory decline, lack of concentration, and other cognitive deficits, which severely affect the quality of life and prognosis of patients. Its incidence…
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Artikel Jurnal
Mediating role of muscle quality in the liver–brain axis: integrated analysis of CT markers of body composition, brain aging, and biomarkers
BackgroundThe liver, skeletal muscle, and brain are interconnected through metabolic and endocrine pathways, constituting a systemic axis that may influence neurodegeneration. Although hepatic steatosis and sarcopenia have been independently associated with neurodegeneration, their integrated…
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Artikel Jurnal
Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration
Parkinson’s disease (PD) is a common neurodegenerative disorder with a rising incidence in aging populations, substantially diminishing patients’ quality of life. Mitochondria are central to neuronal energy metabolism, and mitophagy plays a pivotal role in maintaining mitochondrial quality by…
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Artikel Jurnal
Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson’s disease across the cognitive spectrum
BackgroundHippocampal subregion atrophy has been associated with cognitive decline in Parkinson’s disease (PD). Our study aimed to investigate the functional and structural alterations of the hippocampal subregion in newly diagnosed PD patients presenting with different cognitive states and to…
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Artikel Jurnal
VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model
BackgroudVPS35, a core component of the retromer complex, has been closely associated with neurodegenerative disorders, particularly Parkinson’s disease (PD). The VPS35 D620N mutation has been identified as a pathogenic variant in familial PD. However, the precise mechanisms by which VPS35 and its…
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Artikel Jurnal
Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations
BackgroundThe role of genetic factors in the pathogenesis of Parkinson’s disease (PD) is characterized by heterogeneity in specific genetic variations and their prevalence across different populations and geographic locations.ObjectiveTo investigate the frequency of the Leucine-rich repeat kinase 2…
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Artikel Jurnal
Unvalidated efficacy and significant risks hinder clinical use of deep cervical lymphatic-venous anastomosis for Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and the pathological accumulation of amyloid-beta (Aβ) plaques and tau tangles. Recent studies suggest that dysfunction of the cerebral lymphatic clearance system may contribute to the progression of AD…
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Artikel Jurnal
Primitive reflexes as behavioral biomarkers of cognitive aging: associations with physical activity and resilience—a pilot study
IntroductionPrimitive reflexes (PRs) are brainstem-mediated automatic responses that typically disappear in early life, but may reappear in older age, which may be associated with neurodegenerative processes. But the presence of PRs in cognitively healthy adults has not yet been sufficiently…
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