8,223 results
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Journal Article
Clinical and neuropsychological features associated with progression in subjective cognitive decline
Background and objectivesSubjective Cognitive Decline (SCD) is recognized as an early indicator of neurodegeneration, yet factors that predict its progression to mild cognitive impairment (MCI) or dementia remains not fully understood. In this study, we aim to identify clinical and…
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Journal Article
Music-induced physiological markers for detecting Alzheimer's disease using machine learning
IntroductionAlzheimer's disease (AD) is characterized by progressive cognitive and emotional decline, highlighting the need for novel, non-invasive biomarkers to aid in early detection, monitoring, and stage-specific interventions. This study investigates music-evoked physiological responses as…
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Journal Article
Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study
IntroductionThe aging global population underscores the need to understand brain aging and its links to neurodegenerative diseases. While most brain aging studies use cognitive impairment as exclusion criteria, preclinical biomarkers may influence results, potentially masking early pathological…
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Journal Article
The efficacy versus evidence quality of multicomponent exercise for cognitive health in older adults: an umbrella review
IntroductionMulticomponent exercise (MCE) is a promising strategy for enhancing cognitive function in older adults. This umbrella review aimed to synthesize and critically appraise the evidence from systematic reviews and meta-analyses on the effects of multicomponent physical exercise on cognition…
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Journal Article
The effect of mind–body exercise on cognitive function and neuroplasticity in elderly people with mild cognitive impairment: a systematic review and meta-analysis
ObjectiveThis systematic review and meta-analysis aims to comprehensively analyze the effects of mind–body exercise on cognitive function, brain structure, and brain function in individuals with mild cognitive impairment (MCI) by assessing randomized controlled trials.MethodsA systematic search was…
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Journal Article
The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity
BackgroundChronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI). Patients with CCH frequently exhibit white matter hyperintensities (WMH) on MRI. This study investigated the expression and clinical relevance of megakaryocyte-associated tyrosine kinase…
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Journal Article
Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson’s disease
Parkinson’s disease is a progressive neurodegenerative disorder characterized by degeneration of dopaminergic neurons, leading to significant motor and non-motor symptoms. Recent studies emphasize that exercise is a beneficial intervention, not only helping to decrease the risk of developing of…
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Journal Article
Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study
IntroductionCognitive decline is part of the normal aging process, but also a major risk factor for dementia. Cognitive training interventions aim to attenuate cognitive decline, but training gains need to be transferable to untrained cognitive abilities to influence everyday function. Furthermore…
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Journal Article
Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes
BackgroundLecanemab, a monoclonal antibody targeting soluble amyloid-β protofibrils, has demonstrated efficacy in reducing amyloid burden in patients with mild cognitive impairment (MCI). However, its effects on brain structure, cerebral perfusion, gray matter microstructure and white matter…
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Journal Article
HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia
The potential impact of lifestyle changes such as prolonged fasting on brain health still remains unclear. Neurodegenerative diseases often exhibit two key hallmarks: accumulation of misfolded proteins such as amyloid beta oligomers (AβO) and intracellular cholesterol accumulation. In this study…
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Journal Article
Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis
BackgroundMotor function is a sensitive indicator of cognitive aging but the unique contributions of different motor domains are unclear when assessed together.MethodsWe evaluated 98 community-dwelling older adults (median age: 74). From a neuropsychological battery, a primary Global Cognitive…
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Journal Article
Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching
IntroductionPrevious studies provided inconclusive results regarding the effects of aging on the ability to flexibly switch between task rules (local switch cost). The goal of the present study was to investigate the influence of age on the local switch costs at two levels of difficulty (easy task…
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Journal Article
Altered brain dynamics in post-stroke cognitive and motor dysfunction
BackgroundCurrent research is predominantly focused on the single dysfunction after stroke, but the potential changes in brain dynamics of post-stroke cognitive and motor dysfunction (PSCMD) remain unclear, which hinders a deep understanding of its rehabilitation effects. Therefore, the objective…
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Journal Article
Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment
ObjectiveThis study aimed to investigate the effects of computer-assisted cognitive training (CACT) on cognitive function and activities of daily living in patients with post-stroke cognitive impairment. Additionally, it aimed to explore the changes in specific cognitive domains before and after…
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Journal Article
Virtual reality navigation for the early detection of Alzheimer’s disease
ObjectiveThe development of non-invasive clinical diagnostics is paramount for the early detection of Alzheimer’s disease (AD). Neurofibrillary tangles in AD originate from the entorhinal cortex, a cortical memory area that mediates navigation via path integration (PI). Here, we studied…
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Journal Article
Improvement of neuropsychological and cognitive functions in older adults through transcranial vibroacoustic stimulation: a double blind, randomized, comparative trial
IntroductionCognitive impairments are critical global public health issues. Recent research has focused on developing non-invasive methods for cognitive enhancement with the potential to slow cognitive decline. This study aimed to explore the effects of transcranial vibroacoustic stimulation (tVAS)…
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Journal Article
Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is characterized by progressive cognitive decline and has a long prodromal phase during which subclinical cognitive deficits and neuropsychiatric symptoms may begin to emerge. Apathy, defined as a lack of motivation or volition, is increasingly recognized as a…
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Journal Article
A cross-sectional study of how high-frequency hearing loss impacts cognitive functions in middle-aged-to-older adults
PurposeResearch on the association between hearing loss and cognition has primarily focused on speech-range hearing frequencies (i.e., 0.5–4 kHz), as these frequencies are most relevant to everyday functioning. However, age-related hearing loss (ARHL) tends to impact higher-frequency hearing first…
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Journal Article
NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies
NMDA receptors (NMDARs) are widely distributed throughout the central nervous system (CNS) and play pivotal roles in normal physiological processes such as synaptic plasticity, learning, and memory. Substantial evidence indicates that NMDAR dysfunction, particularly excessive calcium influx…
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