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Artikel Jurnal
Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications
BackgroundFunctional MRI (fMRI) studies conducted on young adults reveal a predominantly left-lateralized cortical language network during semantic and phonological processing (SP and PP, respectively). Both linguistic dimensions have been advanced as potential cognitive markers of pathological…
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Artikel Jurnal
Non-invasive detection of Parkinson’s disease based on speech analysis and interpretable machine learning
ObjectiveParkinson’s disease (PD) is a progressive neurodegenerative disorder that significantly impacts motor function and speech patterns. Early detection of PD through non-invasive methods, such as speech analysis, can improve treatment outcomes and quality of life for patients. This study aims…
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Artikel Jurnal
Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study
BackgroundBoth low handgrip strength (HGS) and abnormal glucose metabolism have been implicated in an increased risk of cognitive impairment. However, whether HGS interacts with glucose metabolism status to influence cognitive function remains unclear. This study explores the relationship between…
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Differences in sensory-motor cortex activation patterns during level and stair walking in patients with knee osteoarthritis: protocol for a cross-sectional study
BackgroundKnee osteoarthritis (KOA) is a chronic degenerative disease characterized primarily by pain and joint dysfunction, especially during level and stair walking. Although traditionally classified as a peripheral joint disease, emerging evidence implicates central nervous system (CNS)…
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Immediate effects of extracorporeal radial pressure wave therapy on dystonia, static plantar pressure distribution, and balance in patients with Parkinson’s disease
BackgroundExtracorporeal radial pressure wave therapy (ERPWT) has emerged as a potential non-invasive treatment for various musculoskeletal and neurological disorders. This study investigates the immediate effects of ERPWT on dystonia, static plantar pressure distribution, and balance in patients…
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Artikel Jurnal
Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study
IntroductionOne of the commonly used indices of short-term memory (STM) is the digit span task. Prior studies have proposed pupil dilation as a measure of task engagement and as a promising biomarker of vagal activation. Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel…
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Artikel Jurnal
Glutamate-associated research in Parkinson’s disease: a bibliometric analysis
BackgroundParkinson’s disease (PD) is a common neurodegenerative disease. As an important excitatory neurotransmitter, glutamate plays a key role in the nervous system. The imbalance of glutamate levels, the dysfunction of related receptors, and the abnormal activity of transporters are closely…
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Artikel Jurnal
Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis
ObjectiveTo systematically assess the impact of TCE on the efficacy of interventions targeting motor symptoms and mobility in people with Parkinson's disease.Methodsa computerized search was performed for randomized controlled trials assessing TCE intervention for motor symptoms and mobility in…
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Artikel Jurnal
Risk prediction of recurrent ischemic stroke based on Carotid Plaque-RADS: construction and validation of a nomogram model
Background and purposeIschemic stroke (IS) is characterized by a high recurrence rate and more serious repercussions. Recently, the Carotid Plaque Reporting and Data System (Carotid Plaque-RADS) has been introduced to gauge and forecast the risk of cerebrovascular incidents. More studies are…
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Artikel Jurnal
Age-related differences in the weighting of kinematic and contextual information during action prediction
IntroductionPredicting others’ behaviors is an essential ability to interact efficiently within the social world. Previous evidence suggests that action prediction entails the integration of incoming sensory information with previous experience and contextual expectations. While it is well known…
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Artikel Jurnal
Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females
Female sex, age, and APOE4 genotype are the greatest risk factors for Alzheimer′s disease. Using a translational perimenopause mouse model based on human Stages of Reproductive Aging Works (STRAW) criteria, we investigated the impact of APOE genotype on female midlife endocrine aging, peripheral…
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Artikel Jurnal
Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative condition associated with aging. As the population ages, the incidence of AD has risen annually, making it the fourth leading cause of death, following cardiovascular disease, cancer, and stroke. The main pathological features of AD are now thought to…
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Artikel Jurnal
Vulnerability of long-range inputome of basal forebrain in normal aging mice
IntroductionAs the human undergoes the process of aging, it becomes evident that the elderly population exhibits age-related cognitive decline. The basal forebrain (BF) has been shown to have complex connections with the hippocampus (Hip) and medial prefrontal cortex (mPFC) through circuits, and is…
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Artikel Jurnal
Investigation of gray matter volume in individuals with heart failure and preserved ejection fraction
ObjectThis study employs voxel-based morphometry techniques to identify potential areas of brain injury in patients with heart failure with preserved ejection fraction (HFpEF). It further assesses the correlation between clinical indicators, cardiac function parameters, and gray matter volume…
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Artikel Jurnal
Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults
ObjectiveSubsyndromal symptomatic depression (SSD) is associated with an increased risk of cognitive impairment in non-demented older adults. However, the mechanism underlying this relationship remains unclear. This study aimed to investigate whether plasma neurofilament light chain (NfL) mediates…
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Artikel Jurnal
Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease
BackgroundThe NeuroArtP3 (NET-2018-12366666) is a multicenter study funded by the Italian Ministry of Health. The aim of the project is to identify the prognostic trajectories of Alzheimer's disease (AD) through the application of artificial intelligence (AI). Only a few AI studies investigated the…
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Artikel Jurnal
Diagnostic value of olfactory function testing for Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
BackgroundAlzheimer’s disease (AD) is clinically classified into prodromal (asymptomatic), mild cognitive impairment (MCI) due to AD, and dementia due to AD. This study investigates the diagnostic value of olfactory function testing for AD and MCI.MethodsSystematic searches of PubMed, Web of…
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Artikel Jurnal
Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit
BackgroundThe relationship between the platelet-to-lymphocyte ratio (PLR) and the prognosis of patients with ischemic stroke was unclear.ObjectiveThis study aimed to explore the correlation between PLR levels and in-hospital mortality in ischemic stroke patients admitted to the intensive care unit…
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Artikel Jurnal
Whole-brain 3D imaging of dopaminergic neurons and glial cells in the mouse model of Parkinson’s disease induced by 6-OHDA
ObjectiveParkinson’s disease (PD) is the second most common neurodegenerative disease. Current understanding of the abnormal neural network in PD is limited, which may be one of the reasons for the lack of effective treatments. Tissue-clearing techniques allow visualization of neurons and gliocytes…
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Artikel Jurnal
Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders
Aging and neurodegenerative diseases are characterized by cognitive decline, impaired neuroplasticity, and epigenetic dysregulation. Curcumin, a bioactive polyphenol derived from Curcuma longa, has gained significant attention for its neuroprotective properties, particularly in enhancing cognitive…
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