8,223 results
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Journal Article
Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer’s disease, with hypertensive dependency
BackgroundNeuroinflammation and hypertension are involved in Alzheimer’s disease (AD). However, their independent and additive impacts on astrocytes and AD-related pathologies have not been fully explored. Hence, this study investigated whether the associations between astrocyte reactivity…
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Journal Article
Neuroimaging insights into lung disease-related brain changes: from structure to function
Lung diseases induce changes in brain structure and function, leading to a range of cognitive, emotional, and motor deficits. The concept of the lung-brain axis has been proposed through neuroanatomy, endocrine, and immune pathway, while a considerable number of studies also explored the existence…
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Journal Article
Uncovering the link between incidental physical activity and inhibition of automatic responses in aging. An ERP study
The concept of cognitive reserve explains how the brain maintains function despite age-related changes or neuropathological damage. Factors such as education, cognitive stimulation, and physical activity contribute to strengthening this reserve. While research has highlighted the benefits of…
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Journal Article
Predicting amyloid status in mild cognitive impairment: the role of semantic intrusions combined with plasma biomarkers
BackgroundThe efficacy of traditional semantic intrusion measurements in identifying amyloid deposition in mild cognitive impairment (MCI) patients remains suboptimal. It is anticipated that integrating innovative cognitive assessments with blood biomarker analyses will enhance the effectiveness of…
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Journal Article
Relationship between executive function and dual-task walking in people with Parkinson's disease
BackgroundCognitive impairment may present early in people with Parkinson's disease (PwPD), with deficits in executive function potentially impacting gait performance. Previous studies have investigated the association between dual-task walking and executive function in PwPD; however, the results…
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Journal Article
Sedentary behavior, cognition, and brain health in older adults: a systematic review
Sedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The…
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Journal Article
Research hotspots and frontiers of glymphatic system and Alzheimer’s disease: a bibliometrics analysis
BackgroundAs a predominant neurodegenerative disorder, Alzheimer’s disease (AD) has garnered increasing attention regarding the association between its pathological mechanisms and glymphatic system (GS) dysfunction.ObjectiveThis study employs bibliometric methods to systematically analyze the…
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Journal Article
Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults
IntroductionOlder age is associated with alterations in executive functioning (EF). Age-related alterations in the integrity of structural brain networks may contribute to EF decline, with potential consequences for independent living. Graph theory provides powerful metrics to examine the brain's…
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Journal Article
Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats
IntroductionA major contributor to age-related hearing loss is the decline of GABAergic inhibition, particularly in the inferior colliculus (IC), which is the midbrain hub of the central auditory system. The initial loss of inhibition is thought to be a compensatory mechanism in response to…
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Journal Article
A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by decreased memory and cognitive impairment. Abnormal tau hyperphosphorylation ultimately forms neurofibrillary tangles, which is one of the most important pathological features of AD. Since we have…
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Journal Article
Neuromotor functions across the lifespan: percentiles from 6 to 80 years
AimTo investigate the dynamics of neuromotor functions from 6 to 80 years with the Zurich Neuromotor Assessment (ZNA) and to provide reference curves for clinical and research use.Materials and methodsNeuromotor data on 1620 individuals (828 females) measured with the ZNA and ZNA-2 between 1983 and…
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Journal Article
Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease
BackgroundIron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer’s disease (AD) and can be measured using quantitative susceptibility mapping (QSM). However, it is unclear if iron measured using QSM is regionally related to tau in atypical…
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Journal Article
Hemodynamic changes and their relationship with white matter hyperintensities in CSVD patients with cognitive impairment: a 4D flow study
ObjectiveTo observe the hemodynamics of intracranial arteries and veins in patients with cerebral small vessel disease (CSVD) with cognitive impairment (CI), and to explore the association between these flow features and white matter hyperintensities (WMH).Materials and methodsA total of 53…
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Journal Article
The burden of Parkinson’s disease, 1990–2021: a systematic analysis of the Global Burden of Disease study 2021
BackgroundThe pathogenesis of Parkinson’s disease (PD) remains incompletely understood, has drawn significant attention within the scope of the Global Burden of Disease (GBD) study. Therefore, to explore PD’s global burden and devise countermeasures is indispensable.MethodsData from GBD 2021 to…
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Journal Article
Predictive value of pan-immune-inflammation value in the prognosis of adults with status epilepticus: a retrospective study
ObjectiveTo investigate the predictive capacity of the pan-immune-inflammation value (PIV) for functional outcomes in patients with status epilepticus (SE).MethodsIn this study, we investigated and confirmed the prognostic significance of PIV in adult patients with SE. Clinical information and…
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Journal Article
Characterizing changes to individual-specific brain signature with age
The increasing prevalence of neurodegenerative diseases in an aging population underscores the critical need for reliable biomarkers distinguishing normal aging from pathological neurodegeneration. This study leverages neuroimaging to identify age-resilient biomarkers, establishing a baseline of…
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Journal Article
The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer’s disease
Alzheimer’s disease (AD) is a severe neurodegenerative disease characterized mainly by the formation of amyloid beta (Aβ) plaques and abnormal phosphorylation of tau. In recent years, an imbalance in iron homeostasis has been recognized to play a key role in the pathological process of AD. Abnormal…
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Journal Article
Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol
BackgroundLifestyle factors like exercise and cognitive stimulation might help improve cognitive performance in older adults. However, studies investigating this, reported mixed results. Most of the data supporting the benefit of exercise comes from cross-sectional studies, cohort studies, or short…
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