8.223 hasil
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Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer’s dementia in a real-world memory clinic population
IntroductionWe need easy-to-use, valid biomarkers for diagnosing Alzheimer’s disease (AD). Blood biomarkers are a promising option, especially as there is a good correlation with beta-amyloid and tau biomarkers measured by positron emission tomography or in the cerebrospinal fluid. We investigated…
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Artikel Jurnal
Development and validation of a clinical prediction model for first fall in early Parkinson’s disease: a study of two fall-naive cohorts
BackgroundFalls are frequent and debilitating complications in Parkinson’s disease (PD), with a substantial risk present even in early stages. Predicting the first fall is critical for preventive interventions, yet existing models are often unsuitable for fall-naive, early PD patients due to their…
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Altered attention and visuospatial abnormalities in Parkinson's disease: links to attention networks and basal ganglia
BackgroundAttentional and visuospatial deficits in Parkinson's disease (PD) are linked to disrupted attention networks (AN), yet specific neural mechanisms remain unclear. This study aims to elucidate the relationship between these dysfunctions and aberrant AN circuits in PD.MethodsSixty-two PD…
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NORRISK 2 score is associated with dementia and MCI—the HUNT study
BackgroundCardiovascular disease (CVD) risk factors are associated with the risk of cognitive decline and dementia. Composite CVD risk scores integrate multiple risk factors and may capture the cumulative burden of CVD risk relevant to cognitive outcomes. However, the long-term association between…
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The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Alzheimer’s and Parkinson’s disease: a systematic review and meta-analysis
Microglia are central nervous system immune cells that support brain homeostasis but can adopt harmful roles in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), depending on the disease stage and progression. Thus, targeting microglia through depletion has…
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Age-related variations of the hemodynamic response function spatially resolved across human cerebral cortex
Normal aging leads to regional vascular and neural alterations. Age-related impairments in neurovascular coupling (NVC) affect the blood-oxygen-level-dependent (BOLD) hemodynamic response function (HRF) measured with functional magnetic resonance imaging, causing changes in both amplitude and…
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Artikel Jurnal
Risk prediction models for cognitive impairment in patients with cerebral small vessel disease: a systematic review and meta-analysis
ObjectiveThis study systematically evaluates the risk prediction models for cognitive impairment in patients with cerebral small vessel disease (CSVD) and explores the predictive factors for cognitive impairment to provide effective guidance for the future development of higher-quality prediction…
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Artikel Jurnal
MultimodalCNN-PD: a Parkinson’s disease diagnostics framework using multimodal convolutional neural network
BackgroundParkinson’s disease (PD) is a prevalent neurodegenerative disorder that severely affects motor and cognitive functions. Early diagnosis, particularly during the prodromal phase, is critical for effective intervention.MethodsThis study presents MultimodalCNN-PD++, a deep learning model…
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Artikel Jurnal
Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway
IntroductionVascular dementia (VaD) is closely associated with oxidative stress and intracellular calcium overload. PLCγ1, IP3R, CAMKKII, and CaM proteins play important roles in mediating intracellular calcium overload and excessive accumulation of reactive oxygen species (ROS). Tongqiao Huashuan…
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Effect of inspired oxygen fraction during anesthesia on inflammation and antioxidant enzyme activity in the mouse cortex and hippocampus
IntroductionAlthough high inspired oxygen fraction (FiO₂) is used during anesthesia to prevent hypoxemia, the effect of different oxygen fraction on the brain remains unclear. This study aims to evaluate whether different inspired oxygen fractions (FiO₂ 30% vs. 80%) during anesthesia affect…
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Artikel Jurnal
Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communication
Alzheimer’s disease (AD) research has transcended the traditional paradigm centered on amyloid-beta (Aβ) shifting toward a neuroimmune network perspective. This article systematically elucidates the evolving mechanisms underlying disease progression, from neuroimmune interactions to intercellular…
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The brain-gut-muscle axis: a mechanism for exercise-mediated protection in brain aging
The global challenge of population aging underscores the critical need to delay brain aging and cognitive decline, a pressing public health issue. The brain-gut-muscle axis is a complex regulatory network connecting skeletal muscle, gut microbiota, and the brain. It has received considerable…
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Artikel Jurnal
Financial abilities in patients with Parkinson’s disease and mild cognitive impairment: unveiling cognitive and neurofunctional correlates of basic and advanced financial skills
BackgroundParkinson’s disease (PD) entails widespread neurodegenerative changes extending beyond motor symptoms to cognitive and large-scale network alterations that compromise functional autonomy. Financial abilities (FAs) are complex, ecologically relevant skills crucial for independent living…
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Deep learning for FDG-PET classification in patients with Alzheimer’s disease, dementia with Lewy bodies and their mixed pathology: a solution for diagnostic heterogeneity
IntroductionMixed pathology of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are frequently observed in patients with cognitive impairment, and complicate clinical diagnosis. We aimed to develop a classification model using 18F-fluorodeoxyglucose (FDG) positron emission tomography…
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A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: protocol for a randomized controlled trial
BackgroundEmerging research suggests virtual reality (VR) techniques hold promise for mitigating cognitive decline in patients with mild cognitive impairment (MCI). Furthermore, accumulating evidence indicates that gut dysbiosis is a key factor associated with cognitive impairment. This study aims…
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Serum proteomics reveals biomarkers for diagnosis, stratification, and mechanistic insights into cerebral microbleeds
ObjectiveCerebral microbleeds (CMBs) are small vascular lesions detectable on MRI and are associated with increased stroke risk and cognitive decline. However, imaging-based diagnosis is limited by cost and accessibility. This study aimed to identify serum protein biomarkers for early CMB diagnosis…
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Artikel Jurnal
Age-related directional asymmetry in the rod-and-frame test
IntroductionIn the classic Rod-and-Frame Test (RFT), participants align a pivoted rod with the vertical while viewing a tilted, coaxially mounted frame. In doing so, they can use the edge of the frame or its imaginary diagonal as visual cues. The error in this simple perceptual task has long been…
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Artikel Jurnal
Interconnected roles of astrocytes and the blood–brain barrier in Parkinson’s disease: pathological evidence, mechanistic insights, and knowledge gaps
Parkinson’s disease (PD) has long been defined by α-synuclein aggregation and dopaminergic neurodegeneration, yet growing evidence indicates that non-neuronal contributors, specifically astrocytes and the blood–brain barrier (BBB), may play key roles in disease progression. Human neuropathological…
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